diff --git a/public/app/plugins/datasource/loki/datasource.test.ts b/public/app/plugins/datasource/loki/datasource.test.ts
index d1db8834080..eda90cbf0b6 100644
--- a/public/app/plugins/datasource/loki/datasource.test.ts
+++ b/public/app/plugins/datasource/loki/datasource.test.ts
@@ -252,6 +252,22 @@ describe('LokiDatasource', () => {
     });
   });
 
+  describe('when running interpolateVariablesInQueries', () => {
+    it('should call addAdHocFilters', () => {
+      const ds = createLokiDatasource(templateSrvStub);
+      ds.addAdHocFilters = jest.fn();
+      const expr = 'rate({bar="baz", job="foo"} [5m]';
+      const queries = [
+        {
+          refId: 'A',
+          expr,
+        },
+      ];
+      ds.interpolateVariablesInQueries(queries, {});
+      expect(ds.addAdHocFilters).toHaveBeenCalledWith(expr);
+    });
+  });
+
   describe('when performing testDataSource', () => {
     let ds: LokiDatasource;
     beforeEach(() => {
diff --git a/public/app/plugins/datasource/loki/datasource.ts b/public/app/plugins/datasource/loki/datasource.ts
index 8aa6b459bb6..dce94ed4b98 100644
--- a/public/app/plugins/datasource/loki/datasource.ts
+++ b/public/app/plugins/datasource/loki/datasource.ts
@@ -272,7 +272,7 @@ export class LokiDatasource
       expandedQueries = queries.map((query) => ({
         ...query,
         datasource: this.getRef(),
-        expr: this.templateSrv.replace(query.expr, scopedVars, this.interpolateQueryExpr),
+        expr: this.addAdHocFilters(this.templateSrv.replace(query.expr, scopedVars, this.interpolateQueryExpr)),
       }));
     }
 
diff --git a/public/app/plugins/datasource/prometheus/datasource.test.ts b/public/app/plugins/datasource/prometheus/datasource.test.ts
index 4b8db23959a..4260dde820b 100644
--- a/public/app/plugins/datasource/prometheus/datasource.test.ts
+++ b/public/app/plugins/datasource/prometheus/datasource.test.ts
@@ -622,6 +622,18 @@ describe('PrometheusDatasource', () => {
       expect(templateSrvStub.replace).toBeCalledTimes(2);
       expect(queries[0].interval).toBe(interval);
     });
+
+    it('should call enhanceExprWithAdHocFilters', () => {
+      ds.enhanceExprWithAdHocFilters = jest.fn();
+      const queries = [
+        {
+          refId: 'A',
+          expr: 'rate({bar="baz", job="foo"} [5m]',
+        },
+      ];
+      ds.interpolateVariablesInQueries(queries, {});
+      expect(ds.enhanceExprWithAdHocFilters).toHaveBeenCalled();
+    });
   });
 
   describe('applyTemplateVariables', () => {
diff --git a/public/app/plugins/datasource/prometheus/datasource.tsx b/public/app/plugins/datasource/prometheus/datasource.tsx
index 729d1aea0b8..ef664ea0a55 100644
--- a/public/app/plugins/datasource/prometheus/datasource.tsx
+++ b/public/app/plugins/datasource/prometheus/datasource.tsx
@@ -1002,7 +1002,9 @@ export class PrometheusDatasource
         const expandedQuery = {
           ...query,
           datasource: this.getRef(),
-          expr: this.templateSrv.replace(query.expr, scopedVars, this.interpolateQueryExpr),
+          expr: this.enhanceExprWithAdHocFilters(
+            this.templateSrv.replace(query.expr, scopedVars, this.interpolateQueryExpr)
+          ),
           interval: this.templateSrv.replace(query.interval, scopedVars),
         };
         return expandedQuery;