diff --git a/packages/grafana-runtime/src/utils/DataSourceWithBackend.test.ts b/packages/grafana-runtime/src/utils/DataSourceWithBackend.test.ts
index 70b0c1b5f8c..90727a27c28 100644
--- a/packages/grafana-runtime/src/utils/DataSourceWithBackend.test.ts
+++ b/packages/grafana-runtime/src/utils/DataSourceWithBackend.test.ts
@@ -2,16 +2,21 @@ import { of } from 'rxjs';
 import { BackendSrv, BackendSrvRequest, FetchResponse } from 'src/services';
 
 import {
-  DataSourceJsonData,
   DataQuery,
-  DataSourceInstanceSettings,
   DataQueryRequest,
   DataQueryResponseData,
-  MutableDataFrame,
+  DataSourceInstanceSettings,
+  DataSourceJsonData,
   DataSourceRef,
+  MutableDataFrame,
 } from '@grafana/data';
 
-import { DataSourceWithBackend, standardStreamOptionsProvider, toStreamingDataResponse } from './DataSourceWithBackend';
+import {
+  DataSourceWithBackend,
+  isExpressionReference,
+  standardStreamOptionsProvider,
+  toStreamingDataResponse,
+} from './DataSourceWithBackend';
 
 class MyDataSource extends DataSourceWithBackend<DataQuery, DataSourceJsonData> {
   constructor(instanceSettings: DataSourceInstanceSettings<DataSourceJsonData>) {
@@ -239,6 +244,16 @@ describe('DataSourceWithBackend', () => {
       url: '/api/datasources/uid/abc/health',
     });
   });
+
+  describe('isExpressionReference', () => {
+    test('check all possible expression references', () => {
+      expect(isExpressionReference('__expr__')).toBeTruthy(); // New UID
+      expect(isExpressionReference('-100')).toBeTruthy(); // Legacy UID
+      expect(isExpressionReference('Expression')).toBeTruthy(); // Name
+      expect(isExpressionReference({ type: '__expr__' })).toBeTruthy();
+      expect(isExpressionReference({ type: '-100' })).toBeTruthy();
+    });
+  });
 });
 
 function createMockDatasource() {
diff --git a/packages/grafana-runtime/src/utils/DataSourceWithBackend.ts b/packages/grafana-runtime/src/utils/DataSourceWithBackend.ts
index eef23c676c8..80b74c3a336 100644
--- a/packages/grafana-runtime/src/utils/DataSourceWithBackend.ts
+++ b/packages/grafana-runtime/src/utils/DataSourceWithBackend.ts
@@ -47,7 +47,7 @@ export function isExpressionReference(ref?: DataSourceRef | string | null): bool
     return false;
   }
   const v = typeof ref === 'string' ? ref : ref.type;
-  return v === ExpressionDatasourceRef.type || v === '-100'; // -100 was a legacy accident that should be removed
+  return v === ExpressionDatasourceRef.type || v === ExpressionDatasourceRef.name || v === '-100'; // -100 was a legacy accident that should be removed
 }
 
 export class HealthCheckError extends Error {
diff --git a/public/app/features/plugins/datasource_srv.ts b/public/app/features/plugins/datasource_srv.ts
index ec05be3cf4b..72153941a50 100644
--- a/public/app/features/plugins/datasource_srv.ts
+++ b/public/app/features/plugins/datasource_srv.ts
@@ -7,15 +7,15 @@ import {
   ScopedVars,
 } from '@grafana/data';
 import {
-  GetDataSourceListFilters,
   DataSourceSrv as DataSourceService,
-  getDataSourceSrv as getDataSourceService,
-  TemplateSrv,
-  getTemplateSrv,
-  getLegacyAngularInjector,
   getBackendSrv,
+  GetDataSourceListFilters,
+  getDataSourceSrv as getDataSourceService,
+  getLegacyAngularInjector,
+  getTemplateSrv,
+  TemplateSrv,
 } from '@grafana/runtime';
-import { ExpressionDatasourceRef } from '@grafana/runtime/src/utils/DataSourceWithBackend';
+import { ExpressionDatasourceRef, isExpressionReference } from '@grafana/runtime/src/utils/DataSourceWithBackend';
 import appEvents from 'app/core/app_events';
 import config from 'app/core/config';
 import {
@@ -80,6 +80,13 @@ export class DatasourceSrv implements DataSourceService {
       return this.settingsMapByUid[this.defaultName] ?? this.settingsMapByName[this.defaultName];
     }
 
+    // Expressions has a new UID as __expr__ See: https://github.com/grafana/grafana/pull/62510/
+    // But we still have dashboards/panels with old expression UID (-100)
+    // To support both UIDs until we migrate them all to new one, this check is necessary
+    if (isExpressionReference(nameOrUid)) {
+      return expressionDatasource.instanceSettings;
+    }
+
     // Complex logic to support template variable data source names
     // For this we just pick the current or first data source in the variable
     if (nameOrUid[0] === '$') {
diff --git a/public/app/features/plugins/tests/datasource_srv.test.ts b/public/app/features/plugins/tests/datasource_srv.test.ts
index 1ab3a3be536..489d579dc32 100644
--- a/public/app/features/plugins/tests/datasource_srv.test.ts
+++ b/public/app/features/plugins/tests/datasource_srv.test.ts
@@ -5,6 +5,7 @@ import {
   DataSourcePluginMeta,
   ScopedVar,
 } from '@grafana/data';
+import { ExpressionDatasourceRef } from '@grafana/runtime/src/utils/DataSourceWithBackend';
 import { DatasourceSrv } from 'app/features/plugins/datasource_srv';
 
 // Datasource variable $datasource with current value 'BBB'
@@ -199,6 +200,25 @@ describe('datasource_srv', () => {
           }
         `);
       });
+
+      it('should return expression settings with either expression UIDs', () => {
+        const exprWithOldUID = dataSourceSrv.getInstanceSettings('-100');
+        expect(exprWithOldUID?.name).toBe('Expression');
+        expect(exprWithOldUID?.uid).toBe(ExpressionDatasourceRef.uid);
+        expect(exprWithOldUID?.type).toBe(ExpressionDatasourceRef.type);
+
+        const exprWithNewUID = dataSourceSrv.getInstanceSettings('__expr__');
+        expect(exprWithNewUID?.name).toBe('Expression');
+        expect(exprWithNewUID?.uid).toBe(ExpressionDatasourceRef.uid);
+        expect(exprWithNewUID?.type).toBe(ExpressionDatasourceRef.type);
+      });
+
+      it('should return expression settings with expression name', () => {
+        const exprWithName = dataSourceSrv.getInstanceSettings('Expression');
+        expect(exprWithName?.name).toBe(ExpressionDatasourceRef.name);
+        expect(exprWithName?.uid).toBe(ExpressionDatasourceRef.uid);
+        expect(exprWithName?.type).toBe(ExpressionDatasourceRef.type);
+      });
     });
 
     describe('when getting external metric sources', () => {