diff --git a/packages/grafana-ui/src/components/DateTimePickers/DateTimePicker/DateTimePicker.mdx b/packages/grafana-ui/src/components/DateTimePickers/DateTimePicker/DateTimePicker.mdx
index 90ecbc0f84a..1302320f7a2 100644
--- a/packages/grafana-ui/src/components/DateTimePickers/DateTimePicker/DateTimePicker.mdx
+++ b/packages/grafana-ui/src/components/DateTimePickers/DateTimePicker/DateTimePicker.mdx
@@ -16,6 +16,26 @@ const [date, setDate] = useState<DateTime>(dateTime('2021-05-05 12:00:00'));
 return <DateTimePicker label="Date" date={date} onChange={setDate} />;
 ```
 
+### With disbled hours, minutes or seconds
+
+```tsx
+import React, { useState } from 'react';
+import { DateTime, dateTime } from '@grafana/data';
+import { DateTimePicker } from '@grafana/ui';
+
+const [date, setDate] = useState<DateTime>(dateTime('2021-05-05 12:00:00'));
+return (
+  <DateTimePicker
+    label="Date"
+    date={date}
+    onChange={setDate}
+    disabledHours={() => [0, 1, 2]}
+    disabledMinutes={() => [10, 15, 30]}
+    disabledSeconds={() => [5, 10, 15, 20]}
+  />
+);
+```
+
 ### Props
 
 <ArgsTable of={DateTimePicker} />
diff --git a/packages/grafana-ui/src/components/DateTimePickers/DateTimePicker/DateTimePicker.story.tsx b/packages/grafana-ui/src/components/DateTimePickers/DateTimePicker/DateTimePicker.story.tsx
index 54ff4dcb5d4..197eff0c72c 100644
--- a/packages/grafana-ui/src/components/DateTimePickers/DateTimePicker/DateTimePicker.story.tsx
+++ b/packages/grafana-ui/src/components/DateTimePickers/DateTimePicker/DateTimePicker.story.tsx
@@ -1,3 +1,4 @@
+import { action } from '@storybook/addon-actions';
 import { ComponentStory, ComponentMeta } from '@storybook/react';
 import React, { useState } from 'react';
 
@@ -8,6 +9,13 @@ import { withCenteredStory } from '../../../utils/storybook/withCenteredStory';
 import { DateTimePicker } from './DateTimePicker';
 import mdx from './DateTimePicker.mdx';
 
+const today = new Date();
+
+// minimum date is initially set to 7 days before to allow the user
+// to quickly see its effects
+const minimumDate = new Date();
+minimumDate.setDate(minimumDate.getDate() - 7);
+
 const meta: ComponentMeta<typeof DateTimePicker> = {
   title: 'Pickers and Editors/TimePickers/DateTimePicker',
   decorators: [withCenteredStory],
@@ -19,6 +27,14 @@ const meta: ComponentMeta<typeof DateTimePicker> = {
     onChange: {
       table: { disable: true },
     },
+    minDate: { control: 'date' },
+    maxDate: { control: 'date' },
+    showSeconds: { control: 'boolean' },
+  },
+  args: {
+    minDate: minimumDate,
+    maxDate: today,
+    showSeconds: true,
   },
   parameters: {
     docs: {
@@ -27,9 +43,54 @@ const meta: ComponentMeta<typeof DateTimePicker> = {
   },
 };
 
-export const Basic: ComponentStory<typeof DateTimePicker> = ({ label }) => {
-  const [date, setDate] = useState<DateTime>(dateTime('2021-05-05 12:00:00'));
-  return <DateTimePicker label={label} date={date} onChange={setDate} />;
+export const OnlyWorkingHoursEnabled: ComponentStory<typeof DateTimePicker> = ({
+  label,
+  minDate,
+  maxDate,
+  showSeconds,
+}) => {
+  const [date, setDate] = useState<DateTime>(dateTime(today));
+  // the minDate arg can change from Date object to number, we need to handle this
+  // scenario to avoid a crash in the component's story.
+  const minDateVal = typeof minDate === 'number' ? new Date(minDate) : minDate;
+  const maxDateVal = typeof maxDate === 'number' ? new Date(maxDate) : maxDate;
+
+  return (
+    <DateTimePicker
+      label={label}
+      disabledHours={() => [0, 1, 2, 3, 4, 5, 6, 19, 20, 21, 22, 23]}
+      minDate={minDateVal}
+      maxDate={maxDateVal}
+      date={date}
+      showSeconds={showSeconds}
+      onChange={(newValue) => {
+        action('on change')(newValue);
+        setDate(newValue);
+      }}
+    />
+  );
+};
+
+export const Basic: ComponentStory<typeof DateTimePicker> = ({ label, minDate, maxDate, showSeconds }) => {
+  const [date, setDate] = useState<DateTime>(dateTime(today));
+  // the minDate arg can change from Date object to number, we need to handle this
+  // scenario to avoid a crash in the component's story.
+  const minDateVal = typeof minDate === 'number' ? new Date(minDate) : minDate;
+  const maxDateVal = typeof maxDate === 'number' ? new Date(maxDate) : maxDate;
+
+  return (
+    <DateTimePicker
+      label={label}
+      minDate={minDateVal}
+      maxDate={maxDateVal}
+      date={date}
+      showSeconds={showSeconds}
+      onChange={(newValue) => {
+        action('on change')(newValue);
+        setDate(newValue);
+      }}
+    />
+  );
 };
 
 Basic.args = {
diff --git a/packages/grafana-ui/src/components/DateTimePickers/DateTimePicker/DateTimePicker.tsx b/packages/grafana-ui/src/components/DateTimePickers/DateTimePicker/DateTimePicker.tsx
index d16b1542619..87f58caa0cd 100644
--- a/packages/grafana-ui/src/components/DateTimePickers/DateTimePicker/DateTimePicker.tsx
+++ b/packages/grafana-ui/src/components/DateTimePickers/DateTimePicker/DateTimePicker.tsx
@@ -25,9 +25,29 @@ export interface Props {
   label?: ReactNode;
   /** Set the latest selectable date */
   maxDate?: Date;
+  /** Set the minimum selectable date */
+  minDate?: Date;
+  /** Display seconds on the time picker */
+  showSeconds?: boolean;
+  /** Set the hours that can't be selected */
+  disabledHours?: () => number[];
+  /** Set the minutes that can't be selected */
+  disabledMinutes?: () => number[];
+  /** Set the seconds that can't be selected */
+  disabledSeconds?: () => number[];
 }
 
-export const DateTimePicker = ({ date, maxDate, label, onChange }: Props) => {
+export const DateTimePicker = ({
+  date,
+  maxDate,
+  minDate,
+  label,
+  onChange,
+  disabledHours,
+  disabledMinutes,
+  disabledSeconds,
+  showSeconds = true,
+}: Props) => {
   const [isOpen, setOpen] = useState(false);
 
   const ref = useRef<HTMLDivElement>(null);
@@ -82,6 +102,7 @@ export const DateTimePicker = ({ date, maxDate, label, onChange }: Props) => {
         onOpen={onOpen}
         label={label}
         ref={setMarkerElement}
+        showSeconds={showSeconds}
       />
       {isOpen ? (
         isFullscreen ? (
@@ -94,8 +115,13 @@ export const DateTimePicker = ({ date, maxDate, label, onChange }: Props) => {
                   isFullscreen={true}
                   onClose={() => setOpen(false)}
                   maxDate={maxDate}
+                  minDate={minDate}
                   ref={setSelectorElement}
                   style={popper.styles.popper}
+                  showSeconds={showSeconds}
+                  disabledHours={disabledHours}
+                  disabledMinutes={disabledMinutes}
+                  disabledSeconds={disabledSeconds}
                 />
               </div>
             </FocusScope>
@@ -108,9 +134,15 @@ export const DateTimePicker = ({ date, maxDate, label, onChange }: Props) => {
                 <div className={styles.modal}>
                   <DateTimeCalendar
                     date={date}
+                    maxDate={maxDate}
+                    minDate={minDate}
                     onChange={onApply}
                     isFullscreen={false}
                     onClose={() => setOpen(false)}
+                    showSeconds={showSeconds}
+                    disabledHours={disabledHours}
+                    disabledMinutes={disabledMinutes}
+                    disabledSeconds={disabledSeconds}
                   />
                 </div>
               </div>
@@ -128,7 +160,12 @@ interface DateTimeCalendarProps {
   onClose: () => void;
   isFullscreen: boolean;
   maxDate?: Date;
+  minDate?: Date;
   style?: React.CSSProperties;
+  showSeconds?: boolean;
+  disabledHours?: () => number[];
+  disabledMinutes?: () => number[];
+  disabledSeconds?: () => number[];
 }
 
 interface InputProps {
@@ -137,6 +174,7 @@ interface InputProps {
   isFullscreen: boolean;
   onChange: (date: DateTime) => void;
   onOpen: (event: FormEvent<HTMLElement>) => void;
+  showSeconds?: boolean;
 }
 
 type InputState = {
@@ -145,7 +183,8 @@ type InputState = {
 };
 
 const DateTimeInput = React.forwardRef<HTMLInputElement, InputProps>(
-  ({ date, label, onChange, isFullscreen, onOpen }, ref) => {
+  ({ date, label, onChange, isFullscreen, onOpen, showSeconds = true }, ref) => {
+    const format = showSeconds ? 'YYYY-MM-DD HH:mm:ss' : 'YYYY-MM-DD HH:mm';
     const [internalDate, setInternalDate] = useState<InputState>(() => {
       return { value: date ? dateTimeFormat(date) : dateTimeFormat(dateTime()), invalid: false };
     });
@@ -153,11 +192,11 @@ const DateTimeInput = React.forwardRef<HTMLInputElement, InputProps>(
     useEffect(() => {
       if (date) {
         setInternalDate({
-          invalid: !isValid(dateTimeFormat(date)),
-          value: isDateTime(date) ? dateTimeFormat(date) : date,
+          invalid: !isValid(dateTimeFormat(date, { format })),
+          value: isDateTime(date) ? dateTimeFormat(date, { format }) : date,
         });
       }
-    }, [date]);
+    }, [date, format]);
 
     const onChangeDate = useCallback((event: FormEvent<HTMLInputElement>) => {
       const isInvalid = !isValid(event.currentTarget.value);
@@ -199,7 +238,22 @@ const DateTimeInput = React.forwardRef<HTMLInputElement, InputProps>(
 DateTimeInput.displayName = 'DateTimeInput';
 
 const DateTimeCalendar = React.forwardRef<HTMLDivElement, DateTimeCalendarProps>(
-  ({ date, onClose, onChange, isFullscreen, maxDate, style }, ref) => {
+  (
+    {
+      date,
+      onClose,
+      onChange,
+      isFullscreen,
+      maxDate,
+      minDate,
+      style,
+      showSeconds = true,
+      disabledHours,
+      disabledMinutes,
+      disabledSeconds,
+    },
+    ref
+  ) => {
     const calendarStyles = useStyles2(getBodyStyles);
     const styles = useStyles2(getStyles);
     const [internalDate, setInternalDate] = useState<Date>(() => {
@@ -243,9 +297,17 @@ const DateTimeCalendar = React.forwardRef<HTMLDivElement, DateTimeCalendarProps>
           className={calendarStyles.body}
           tileClassName={calendarStyles.title}
           maxDate={maxDate}
+          minDate={minDate}
         />
         <div className={styles.time}>
-          <TimeOfDayPicker showSeconds={true} onChange={onChangeTime} value={dateTime(internalDate)} />
+          <TimeOfDayPicker
+            showSeconds={showSeconds}
+            onChange={onChangeTime}
+            value={dateTime(internalDate)}
+            disabledHours={disabledHours}
+            disabledMinutes={disabledMinutes}
+            disabledSeconds={disabledSeconds}
+          />
         </div>
         <HorizontalGroup>
           <Button type="button" onClick={() => onChange(dateTime(internalDate))}>
diff --git a/packages/grafana-ui/src/components/DateTimePickers/TimeOfDayPicker.tsx b/packages/grafana-ui/src/components/DateTimePickers/TimeOfDayPicker.tsx
index 7f8015ca00e..646d4422537 100644
--- a/packages/grafana-ui/src/components/DateTimePickers/TimeOfDayPicker.tsx
+++ b/packages/grafana-ui/src/components/DateTimePickers/TimeOfDayPicker.tsx
@@ -17,6 +17,9 @@ export interface Props {
   minuteStep?: number;
   size?: FormInputSize;
   disabled?: boolean;
+  disabledHours?: () => number[];
+  disabledMinutes?: () => number[];
+  disabledSeconds?: () => number[];
 }
 
 export const POPUP_CLASS_NAME = 'time-of-day-picker-panel';
@@ -29,6 +32,9 @@ export const TimeOfDayPicker = ({
   value,
   size = 'auto',
   disabled,
+  disabledHours,
+  disabledMinutes,
+  disabledSeconds,
 }: Props) => {
   const styles = useStyles2(getStyles);
 
@@ -45,6 +51,9 @@ export const TimeOfDayPicker = ({
       minuteStep={minuteStep}
       inputIcon={<Caret wrapperStyle={styles.caretWrapper} />}
       disabled={disabled}
+      disabledHours={disabledHours}
+      disabledMinutes={disabledMinutes}
+      disabledSeconds={disabledSeconds}
     />
   );
 };
@@ -93,6 +102,10 @@ const getStyles = (theme: GrafanaTheme2) => {
           &:hover {
             background: ${optionBgHover};
           }
+
+          &.rc-time-picker-panel-select-option-disabled {
+            color: ${theme.colors.action.disabledText};
+          }
         }
       }
 
diff --git a/packages/grafana-ui/src/components/DateTimePickers/TimeRangePicker/CalendarBody.tsx b/packages/grafana-ui/src/components/DateTimePickers/TimeRangePicker/CalendarBody.tsx
index f3d3ed700ad..058992128d8 100644
--- a/packages/grafana-ui/src/components/DateTimePickers/TimeRangePicker/CalendarBody.tsx
+++ b/packages/grafana-ui/src/components/DateTimePickers/TimeRangePicker/CalendarBody.tsx
@@ -78,6 +78,10 @@ export const getBodyStyles = (theme: GrafanaTheme2) => {
       &:hover {
         position: relative;
       }
+
+      &:disabled {
+        color: ${theme.colors.action.disabledText};
+      }
     `,
     body: css`
       z-index: ${theme.zIndex.modal};