diff --git a/pkg/services/pluginsintegration/clientmiddleware/grafana_request_id_header_middleware.go b/pkg/services/pluginsintegration/clientmiddleware/grafana_request_id_header_middleware.go
index f8282cd27e5..7637c8b0513 100644
--- a/pkg/services/pluginsintegration/clientmiddleware/grafana_request_id_header_middleware.go
+++ b/pkg/services/pluginsintegration/clientmiddleware/grafana_request_id_header_middleware.go
@@ -5,7 +5,7 @@ import (
 	"crypto/hmac"
 	"crypto/sha256"
 	"encoding/hex"
-	"path"
+	"net/url"
 
 	"github.com/google/uuid"
 
@@ -49,17 +49,22 @@ func (m *HostedGrafanaACHeaderMiddleware) applyGrafanaRequestIDHeader(ctx contex
 	}
 
 	// Check if the request is for a datasource that is allowed to have the header
-	target := pCtx.DataSourceInstanceSettings.URL
-
+	dsURL := pCtx.DataSourceInstanceSettings.URL
+	dsBaseURL, err := url.Parse(dsURL)
+	if err != nil {
+		m.log.Debug("Failed to parse data source URL", "error", err)
+		return
+	}
 	foundMatch := false
 	for _, allowedURL := range m.cfg.IPRangeACAllowedURLs {
-		if path.Clean(allowedURL) == path.Clean(target) {
+		// Only look at the scheme and host, ignore the path
+		if allowedURL.Host == dsBaseURL.Host && allowedURL.Scheme == dsBaseURL.Scheme {
 			foundMatch = true
 			break
 		}
 	}
 	if !foundMatch {
-		m.log.Debug("Data source URL not among the allow-listed URLs", "url", target)
+		m.log.Debug("Data source URL not among the allow-listed URLs", "url", dsBaseURL.String())
 		return
 	}
 
diff --git a/pkg/services/pluginsintegration/clientmiddleware/grafana_request_id_header_middleware_test.go b/pkg/services/pluginsintegration/clientmiddleware/grafana_request_id_header_middleware_test.go
index 8204c70d4af..3c389edea1d 100644
--- a/pkg/services/pluginsintegration/clientmiddleware/grafana_request_id_header_middleware_test.go
+++ b/pkg/services/pluginsintegration/clientmiddleware/grafana_request_id_header_middleware_test.go
@@ -6,6 +6,7 @@ import (
 	"crypto/sha256"
 	"encoding/hex"
 	"net/http"
+	"net/url"
 	"testing"
 
 	"github.com/stretchr/testify/require"
@@ -22,7 +23,8 @@ import (
 func Test_HostedGrafanaACHeaderMiddleware(t *testing.T) {
 	t.Run("Should set Grafana request ID headers if the data source URL is in the allow list", func(t *testing.T) {
 		cfg := setting.NewCfg()
-		cfg.IPRangeACAllowedURLs = []string{"https://logs.grafana.net"}
+		allowedURL := &url.URL{Scheme: "https", Host: "logs.grafana.net"}
+		cfg.IPRangeACAllowedURLs = []*url.URL{allowedURL}
 		cfg.IPRangeACSecretKey = "secret"
 		cdt := clienttest.NewClientDecoratorTest(t, clienttest.WithMiddlewares(NewHostedGrafanaACHeaderMiddleware(cfg)))
 
@@ -63,7 +65,8 @@ func Test_HostedGrafanaACHeaderMiddleware(t *testing.T) {
 
 	t.Run("Should not set Grafana request ID headers if the data source URL is not in the allow list", func(t *testing.T) {
 		cfg := setting.NewCfg()
-		cfg.IPRangeACAllowedURLs = []string{"https://logs.grafana.net"}
+		allowedURL := &url.URL{Scheme: "https", Host: "logs.grafana.net"}
+		cfg.IPRangeACAllowedURLs = []*url.URL{allowedURL}
 		cfg.IPRangeACSecretKey = "secret"
 		cdt := clienttest.NewClientDecoratorTest(t, clienttest.WithMiddlewares(NewHostedGrafanaACHeaderMiddleware(cfg)))
 
@@ -85,9 +88,10 @@ func Test_HostedGrafanaACHeaderMiddleware(t *testing.T) {
 		require.Len(t, cdt.CallResourceReq.Headers[GrafanaSignedRequestID], 0)
 	})
 
-	t.Run("Should set Grafana request ID headers if a sanitized data source URL is in the allow list", func(t *testing.T) {
+	t.Run("Should set Grafana request ID headers if URL scheme and host match a URL from the allow list", func(t *testing.T) {
 		cfg := setting.NewCfg()
-		cfg.IPRangeACAllowedURLs = []string{"https://logs.GRAFANA.net/"}
+		allowedURL := &url.URL{Scheme: "https", Host: "logs.grafana.net"}
+		cfg.IPRangeACAllowedURLs = []*url.URL{allowedURL}
 		cfg.IPRangeACSecretKey = "secret"
 		cdt := clienttest.NewClientDecoratorTest(t, clienttest.WithMiddlewares(NewHostedGrafanaACHeaderMiddleware(cfg)))
 
@@ -99,19 +103,20 @@ func Test_HostedGrafanaACHeaderMiddleware(t *testing.T) {
 		err := cdt.Decorator.CallResource(ctx, &backend.CallResourceRequest{
 			PluginContext: backend.PluginContext{
 				DataSourceInstanceSettings: &backend.DataSourceInstanceSettings{
-					URL: "https://logs.grafana.net/abc/../",
+					URL: "https://logs.grafana.net/abc/../some/path",
 				},
 			},
 		}, nopCallResourceSender)
 		require.NoError(t, err)
 
-		require.Len(t, cdt.CallResourceReq.Headers[GrafanaRequestID], 0)
-		require.Len(t, cdt.CallResourceReq.Headers[GrafanaSignedRequestID], 0)
+		require.Len(t, cdt.CallResourceReq.Headers[GrafanaRequestID], 1)
+		require.Len(t, cdt.CallResourceReq.Headers[GrafanaSignedRequestID], 1)
 	})
 
 	t.Run("Should set Grafana internal request header if the request is internal (doesn't have X-Real-IP header set)", func(t *testing.T) {
 		cfg := setting.NewCfg()
-		cfg.IPRangeACAllowedURLs = []string{"https://logs.grafana.net"}
+		allowedURL := &url.URL{Scheme: "https", Host: "logs.grafana.net"}
+		cfg.IPRangeACAllowedURLs = []*url.URL{allowedURL}
 		cfg.IPRangeACSecretKey = "secret"
 		cdt := clienttest.NewClientDecoratorTest(t, clienttest.WithMiddlewares(NewHostedGrafanaACHeaderMiddleware(cfg)))
 
diff --git a/pkg/setting/setting.go b/pkg/setting/setting.go
index 95a28baafa5..c00b5e50091 100644
--- a/pkg/setting/setting.go
+++ b/pkg/setting/setting.go
@@ -339,7 +339,7 @@ type Cfg struct {
 
 	// IP range access control
 	IPRangeACEnabled     bool
-	IPRangeACAllowedURLs []string
+	IPRangeACAllowedURLs []*url.URL
 	IPRangeACSecretKey   string
 
 	// SQL Data sources
@@ -1949,7 +1949,15 @@ func (cfg *Cfg) readDataSourceSecuritySettings() {
 	cfg.IPRangeACEnabled = datasources.Key("enabled").MustBool(false)
 	cfg.IPRangeACSecretKey = datasources.Key("secret_key").MustString("")
 	allowedURLString := datasources.Key("allow_list").MustString("")
-	cfg.IPRangeACAllowedURLs = util.SplitString(allowedURLString)
+	for _, urlString := range util.SplitString(allowedURLString) {
+		allowedURL, err := url.Parse(urlString)
+		if err != nil {
+			cfg.Logger.Error("Error parsing allowed URL for IP range access control", "error", err)
+			continue
+		} else {
+			cfg.IPRangeACAllowedURLs = append(cfg.IPRangeACAllowedURLs, allowedURL)
+		}
+	}
 }
 
 func (cfg *Cfg) readSqlDataSourceSettings() {