diff --git a/pkg/services/ngalert/api/api_alertmanager.go b/pkg/services/ngalert/api/api_alertmanager.go
index c00324cdf38..0a3ddb25f87 100644
--- a/pkg/services/ngalert/api/api_alertmanager.go
+++ b/pkg/services/ngalert/api/api_alertmanager.go
@@ -168,6 +168,11 @@ func (srv AlertmanagerSrv) RouteGetSilences(c *models.ReqContext) response.Respo
 }
 
 func (srv AlertmanagerSrv) RoutePostAlertingConfig(c *models.ReqContext, body apimodels.PostableUserConfig) response.Response {
+	err := body.EncryptSecureSettings()
+	if err != nil {
+		return response.Error(http.StatusInternalServerError, "failed to encrypt receiver secrets", err)
+	}
+
 	if err := srv.am.SaveAndApplyConfig(&body); err != nil {
 		return response.Error(http.StatusInternalServerError, "failed to save and apply Alertmanager configuration", err)
 	}
diff --git a/pkg/services/ngalert/api/tooling/definitions/alertmanager.go b/pkg/services/ngalert/api/tooling/definitions/alertmanager.go
index af371e642d2..fdc9792900d 100644
--- a/pkg/services/ngalert/api/tooling/definitions/alertmanager.go
+++ b/pkg/services/ngalert/api/tooling/definitions/alertmanager.go
@@ -1,11 +1,14 @@
 package definitions
 
 import (
+	"encoding/base64"
 	"encoding/json"
 	"fmt"
 
 	"github.com/grafana/grafana/pkg/api/dtos"
 	"github.com/grafana/grafana/pkg/models"
+	"github.com/grafana/grafana/pkg/setting"
+	"github.com/grafana/grafana/pkg/util"
 	"github.com/prometheus/alertmanager/config"
 	"gopkg.in/yaml.v3"
 
@@ -242,6 +245,26 @@ func (c *PostableUserConfig) validate() error {
 	return nil
 }
 
+func (c *PostableUserConfig) EncryptSecureSettings() error {
+	// encrypt secure settings for storing them in DB
+	for _, r := range c.AlertmanagerConfig.Receivers {
+		switch r.Type() {
+		case GrafanaReceiverType:
+			for _, gr := range r.PostableGrafanaReceivers.GrafanaManagedReceivers {
+				for k, v := range gr.SecureSettings {
+					encryptedData, err := util.Encrypt([]byte(v), setting.SecretKey)
+					if err != nil {
+						return fmt.Errorf("failed to encrypt secure settings: %w", err)
+					}
+					gr.SecureSettings[k] = base64.StdEncoding.EncodeToString(encryptedData)
+				}
+			}
+		default:
+		}
+	}
+	return nil
+}
+
 // MarshalYAML implements yaml.Marshaller.
 func (c *PostableUserConfig) MarshalYAML() (interface{}, error) {
 	yml, err := yaml.Marshal(c.amSimple)
diff --git a/pkg/services/ngalert/notifier/alertmanager.go b/pkg/services/ngalert/notifier/alertmanager.go
index dd25bee70d5..85d5bb22c90 100644
--- a/pkg/services/ngalert/notifier/alertmanager.go
+++ b/pkg/services/ngalert/notifier/alertmanager.go
@@ -3,6 +3,7 @@ package notifier
 import (
 	"context"
 	"crypto/md5"
+	"encoding/base64"
 	"encoding/json"
 	"errors"
 	"fmt"
@@ -223,7 +224,7 @@ func (am *Alertmanager) SaveAndApplyConfig(cfg *apimodels.PostableUserConfig) er
 	if err := am.Store.SaveAlertmanagerConfiguration(cmd); err != nil {
 		return fmt.Errorf("failed to save Alertmanager configuration: %w", err)
 	}
-	if err := am.applyConfig(cfg); err != nil {
+	if err := am.applyConfig(cfg, rawConfig); err != nil {
 		return fmt.Errorf("unable to reload configuration: %w", err)
 	}
 
@@ -252,32 +253,27 @@ func (am *Alertmanager) SyncAndApplyConfigFromDatabase() error {
 		return err
 	}
 
-	if err := am.applyConfig(cfg); err != nil {
+	if err := am.applyConfig(cfg, nil); err != nil {
 		return fmt.Errorf("unable to reload configuration: %w", err)
 	}
 
 	return nil
 }
 
-// ApplyConfig applies a new configuration by re-initializing all components using the configuration provided.
-func (am *Alertmanager) ApplyConfig(cfg *apimodels.PostableUserConfig) error {
-	am.reloadConfigMtx.Lock()
-	defer am.reloadConfigMtx.Unlock()
-
-	return am.applyConfig(cfg)
-}
-
 const defaultTemplate = "templates/default.tmpl"
 
 // applyConfig applies a new configuration by re-initializing all components using the configuration provided.
 // It is not safe to call concurrently.
-func (am *Alertmanager) applyConfig(cfg *apimodels.PostableUserConfig) error {
+func (am *Alertmanager) applyConfig(cfg *apimodels.PostableUserConfig, rawConfig []byte) error {
 	// First, let's make sure this config is not already loaded
 	var configChanged bool
-	rawConfig, err := json.Marshal(cfg.AlertmanagerConfig)
-	if err != nil {
-		// In theory, this should never happen.
-		return err
+	if rawConfig == nil {
+		enc, err := json.Marshal(cfg.AlertmanagerConfig)
+		if err != nil {
+			// In theory, this should never happen.
+			return err
+		}
+		rawConfig = enc
 	}
 
 	if md5.Sum(am.config) != md5.Sum(rawConfig) {
@@ -380,6 +376,16 @@ func (am *Alertmanager) buildReceiverIntegrations(receiver *apimodels.PostableAp
 	var integrations []notify.Integration
 
 	for i, r := range receiver.GrafanaManagedReceivers {
+		// secure settings are already encrypted at this point
+		secureSettings := securejsondata.SecureJsonData(make(map[string][]byte, len(r.SecureSettings)))
+
+		for k, v := range r.SecureSettings {
+			d, err := base64.StdEncoding.DecodeString(v)
+			if err != nil {
+				return nil, fmt.Errorf("failed to decode secure setting")
+			}
+			secureSettings[k] = d
+		}
 		var (
 			cfg = &models.AlertNotification{
 				Uid:                   r.Uid,
@@ -389,7 +395,7 @@ func (am *Alertmanager) buildReceiverIntegrations(receiver *apimodels.PostableAp
 				SendReminder:          r.SendReminder,
 				DisableResolveMessage: r.DisableResolveMessage,
 				Settings:              r.Settings,
-				SecureSettings:        securejsondata.GetEncryptedJsonData(r.SecureSettings),
+				SecureSettings:        secureSettings,
 			}
 			n   NotificationChannel
 			err error
@@ -409,6 +415,8 @@ func (am *Alertmanager) buildReceiverIntegrations(receiver *apimodels.PostableAp
 			n, err = channels.NewDingDingNotifier(cfg, tmpl)
 		case "webhook":
 			n, err = channels.NewWebHookNotifier(cfg, tmpl)
+		default:
+			return nil, fmt.Errorf("notifier %s is not supported", r.Type)
 		}
 		if err != nil {
 			return nil, err