diff --git a/public/app/plugins/datasource/prometheus/components/monaco-query-field/monaco-completion-provider/completions.ts b/public/app/plugins/datasource/prometheus/components/monaco-query-field/monaco-completion-provider/completions.ts
index eb3e2c56291..dc67d7c9d52 100644
--- a/public/app/plugins/datasource/prometheus/components/monaco-query-field/monaco-completion-provider/completions.ts
+++ b/public/app/plugins/datasource/prometheus/components/monaco-query-field/monaco-completion-provider/completions.ts
@@ -80,10 +80,10 @@ function makeSelector(metricName: string | undefined, labels: Label[]): string {
 
   // we transform the metricName to a label, if it exists
   if (metricName !== undefined) {
-    allLabels.push({ name: '__name__', value: metricName });
+    allLabels.push({ name: '__name__', value: metricName, op: '=' });
   }
 
-  const allLabelTexts = allLabels.map((label) => `${label.name}="${label.value}"`);
+  const allLabelTexts = allLabels.map((label) => `${label.name}${label.op}"${label.value}"`);
 
   return `{${allLabelTexts.join(',')}}`;
 }
diff --git a/public/app/plugins/datasource/prometheus/components/monaco-query-field/monaco-completion-provider/index.ts b/public/app/plugins/datasource/prometheus/components/monaco-query-field/monaco-completion-provider/index.ts
index eeb8a3e040d..3ef3f299bdb 100644
--- a/public/app/plugins/datasource/prometheus/components/monaco-query-field/monaco-completion-provider/index.ts
+++ b/public/app/plugins/datasource/prometheus/components/monaco-query-field/monaco-completion-provider/index.ts
@@ -74,7 +74,7 @@ export function getCompletionProvider(
   };
 
   return {
-    triggerCharacters: ['{', ',', '[', '(', '='],
+    triggerCharacters: ['{', ',', '[', '(', '=', '~'],
     provideCompletionItems,
   };
 }
diff --git a/public/app/plugins/datasource/prometheus/components/monaco-query-field/monaco-completion-provider/intent.test.ts b/public/app/plugins/datasource/prometheus/components/monaco-query-field/monaco-completion-provider/intent.test.ts
index d07ffa97ba4..860fa4ad399 100644
--- a/public/app/plugins/datasource/prometheus/components/monaco-query-field/monaco-completion-provider/intent.test.ts
+++ b/public/app/plugins/datasource/prometheus/components/monaco-query-field/monaco-completion-provider/intent.test.ts
@@ -67,12 +67,14 @@ describe('intent', () => {
       otherLabels: [],
     });
 
-    assertIntent('something{one="val1",two="val2",^}', {
+    assertIntent('something{one="val1",two!="val2",three=~"val3",four!~"val4",^}', {
       type: 'LABEL_NAMES_FOR_SELECTOR',
       metricName: 'something',
       otherLabels: [
-        { name: 'one', value: 'val1' },
-        { name: 'two', value: 'val2' },
+        { name: 'one', value: 'val1', op: '=' },
+        { name: 'two', value: 'val2', op: '!=' },
+        { name: 'three', value: 'val3', op: '=~' },
+        { name: 'four', value: 'val4', op: '!~' },
       ],
     });
 
@@ -83,7 +85,7 @@ describe('intent', () => {
 
     assertIntent('{one="val1",^}', {
       type: 'LABEL_NAMES_FOR_SELECTOR',
-      otherLabels: [{ name: 'one', value: 'val1' }],
+      otherLabels: [{ name: 'one', value: 'val1', op: '=' }],
     });
   });
 
@@ -95,28 +97,49 @@ describe('intent', () => {
       otherLabels: [],
     });
 
+    assertIntent('something{job!=^}', {
+      type: 'LABEL_VALUES',
+      metricName: 'something',
+      labelName: 'job',
+      otherLabels: [],
+    });
+
+    assertIntent('something{job=~^}', {
+      type: 'LABEL_VALUES',
+      metricName: 'something',
+      labelName: 'job',
+      otherLabels: [],
+    });
+
+    assertIntent('something{job!~^}', {
+      type: 'LABEL_VALUES',
+      metricName: 'something',
+      labelName: 'job',
+      otherLabels: [],
+    });
+
     assertIntent('something{job=^,host="h1"}', {
       type: 'LABEL_VALUES',
       metricName: 'something',
       labelName: 'job',
-      otherLabels: [{ name: 'host', value: 'h1' }],
+      otherLabels: [{ name: 'host', value: 'h1', op: '=' }],
     });
 
     assertIntent('{job=^,host="h1"}', {
       type: 'LABEL_VALUES',
       labelName: 'job',
-      otherLabels: [{ name: 'host', value: 'h1' }],
+      otherLabels: [{ name: 'host', value: 'h1', op: '=' }],
     });
 
-    assertIntent('something{one="val1",two="val2",three=^,four="val4",five="val5"}', {
+    assertIntent('something{one="val1",two!="val2",three=^,four=~"val4",five!~"val5"}', {
       type: 'LABEL_VALUES',
       metricName: 'something',
       labelName: 'three',
       otherLabels: [
-        { name: 'one', value: 'val1' },
-        { name: 'two', value: 'val2' },
-        { name: 'four', value: 'val4' },
-        { name: 'five', value: 'val5' },
+        { name: 'one', value: 'val1', op: '=' },
+        { name: 'two', value: 'val2', op: '!=' },
+        { name: 'four', value: 'val4', op: '=~' },
+        { name: 'five', value: 'val5', op: '!~' },
       ],
     });
   });
diff --git a/public/app/plugins/datasource/prometheus/components/monaco-query-field/monaco-completion-provider/intent.ts b/public/app/plugins/datasource/prometheus/components/monaco-query-field/monaco-completion-provider/intent.ts
index ff66cdbefff..4f1bf2f6293 100644
--- a/public/app/plugins/datasource/prometheus/components/monaco-query-field/monaco-completion-provider/intent.ts
+++ b/public/app/plugins/datasource/prometheus/components/monaco-query-field/monaco-completion-provider/intent.ts
@@ -2,7 +2,7 @@ import { parser } from 'lezer-promql';
 import type { Tree, SyntaxNode } from 'lezer-tree';
 import { NeverCaseError } from './util';
 
-type Direction = 'parent' | 'firstChild' | 'lastChild';
+type Direction = 'parent' | 'firstChild' | 'lastChild' | 'nextSibling';
 type NodeTypeName =
   | '⚠' // this is used as error-name
   | 'AggregateExpr'
@@ -18,7 +18,12 @@ type NodeTypeName =
   | 'PromQL'
   | 'StringLiteral'
   | 'VectorSelector'
-  | 'MatrixSelector';
+  | 'MatrixSelector'
+  | 'MatchOp'
+  | 'EqlSingle'
+  | 'Neq'
+  | 'EqlRegex'
+  | 'NeqRegex';
 
 type Path = Array<[Direction, NodeTypeName]>;
 
@@ -30,6 +35,8 @@ function move(node: SyntaxNode, direction: Direction): SyntaxNode | null {
       return node.firstChild;
     case 'lastChild':
       return node.lastChild;
+    case 'nextSibling':
+      return node.nextSibling;
     default:
       throw new NeverCaseError(direction);
   }
@@ -69,9 +76,12 @@ function parsePromQLStringLiteral(text: string): string {
   }
 }
 
+type LabelOperator = '=' | '!=' | '=~' | '!~';
+
 export type Label = {
   name: string;
   value: string;
+  op: LabelOperator;
 };
 
 export type Intent =
@@ -142,6 +152,22 @@ const RESOLVERS: Resolver[] = [
   },
 ];
 
+const LABEL_OP_MAP = new Map<string, LabelOperator>([
+  ['EqlSingle', '='],
+  ['EqlRegex', '=~'],
+  ['Neq', '!='],
+  ['NeqRegex', '!~'],
+]);
+
+function getLabelOp(opNode: SyntaxNode): LabelOperator | null {
+  const opChild = opNode.firstChild;
+  if (opChild === null) {
+    return null;
+  }
+
+  return LABEL_OP_MAP.get(opChild.name) ?? null;
+}
+
 function getLabel(labelMatcherNode: SyntaxNode, text: string): Label | null {
   if (labelMatcherNode.type.name !== 'LabelMatcher') {
     return null;
@@ -153,6 +179,16 @@ function getLabel(labelMatcherNode: SyntaxNode, text: string): Label | null {
     return null;
   }
 
+  const opNode = walk(nameNode, [['nextSibling', 'MatchOp']]);
+  if (opNode === null) {
+    return null;
+  }
+
+  const op = getLabelOp(opNode);
+  if (op === null) {
+    return null;
+  }
+
   const valueNode = walk(labelMatcherNode, [['lastChild', 'StringLiteral']]);
 
   if (valueNode === null) {
@@ -162,7 +198,7 @@ function getLabel(labelMatcherNode: SyntaxNode, text: string): Label | null {
   const name = getNodeText(nameNode, text);
   const value = parsePromQLStringLiteral(getNodeText(valueNode, text));
 
-  return { name, value };
+  return { name, value, op };
 }
 function getLabels(labelMatchersNode: SyntaxNode, text: string): Label[] {
   if (labelMatchersNode.type.name !== 'LabelMatchers') {