diff --git a/public/app/features/dashboard/components/AnnotationSettings/AnnotationSettingsEdit.tsx b/public/app/features/dashboard/components/AnnotationSettings/AnnotationSettingsEdit.tsx
index 2b97dbd4b0d..c1a6474f248 100644
--- a/public/app/features/dashboard/components/AnnotationSettings/AnnotationSettingsEdit.tsx
+++ b/public/app/features/dashboard/components/AnnotationSettings/AnnotationSettingsEdit.tsx
@@ -121,9 +121,11 @@ export const AnnotationSettingsEdit = ({ editIdx, dashboard }: Props) => {
         {ds && !ds.annotations && <AngularEditorLoader datasource={ds} annotation={annotation} onChange={onUpdate} />}
       </FieldSet>
       <Stack>
-        <Button variant="destructive" onClick={onDelete}>
-          Delete
-        </Button>
+        {!annotation.builtIn && (
+          <Button variant="destructive" onClick={onDelete}>
+            Delete
+          </Button>
+        )}
         <Button variant="secondary" onClick={onPreview}>
           Preview in dashboard
         </Button>
diff --git a/public/app/features/dashboard/components/AnnotationSettings/AnnotationSettingsList.tsx b/public/app/features/dashboard/components/AnnotationSettings/AnnotationSettingsList.tsx
index 6d68762e4a7..e413f1e02f5 100644
--- a/public/app/features/dashboard/components/AnnotationSettings/AnnotationSettingsList.tsx
+++ b/public/app/features/dashboard/components/AnnotationSettings/AnnotationSettingsList.tsx
@@ -1,6 +1,6 @@
 import React, { useState } from 'react';
 
-import { arrayUtils } from '@grafana/data';
+import { arrayUtils, AnnotationQuery } from '@grafana/data';
 import { getDataSourceSrv } from '@grafana/runtime';
 import { DeleteButton, Icon, IconButton, VerticalGroup } from '@grafana/ui';
 import EmptyListCTA from 'app/core/components/EmptyListCTA/EmptyListCTA';
@@ -29,6 +29,30 @@ export const AnnotationSettingsList = ({ dashboard, onNew, onEdit }: Props) => {
 
   const showEmptyListCTA = annotations.length === 0 || (annotations.length === 1 && annotations[0].builtIn);
 
+  const getAnnotationName = (anno: AnnotationQuery) => {
+    if (anno.enable === false) {
+      return (
+        <>
+          <Icon name="times" /> &nbsp;<em className="muted">(Disabled) &nbsp; {anno.name}</em>
+        </>
+      );
+    }
+
+    if (anno.builtIn) {
+      return (
+        <>
+          <Icon name="comment-alt" /> &nbsp;<em className="muted">{anno.name} (Built-in)</em>
+        </>
+      );
+    }
+
+    return (
+      <>
+        <Icon name="comment-alt" /> &nbsp;{anno.name}
+      </>
+    );
+  };
+
   const dataSourceSrv = getDataSourceSrv();
   return (
     <VerticalGroup>
@@ -46,11 +70,11 @@ export const AnnotationSettingsList = ({ dashboard, onNew, onEdit }: Props) => {
               <tr key={`${annotation.name}-${idx}`}>
                 {annotation.builtIn ? (
                   <td style={{ width: '90%' }} className="pointer" onClick={() => onEdit(idx)}>
-                    <Icon name="comment-alt" /> &nbsp; <em className="muted">{annotation.name} (Built-in)</em>
+                    {getAnnotationName(annotation)}
                   </td>
                 ) : (
                   <td className="pointer" onClick={() => onEdit(idx)}>
-                    <Icon name="comment-alt" /> &nbsp; {annotation.name}
+                    {getAnnotationName(annotation)}
                   </td>
                 )}
                 <td className="pointer" onClick={() => onEdit(idx)}>
@@ -65,11 +89,13 @@ export const AnnotationSettingsList = ({ dashboard, onNew, onEdit }: Props) => {
                   ) : null}
                 </td>
                 <td style={{ width: '1%' }}>
-                  <DeleteButton
-                    size="sm"
-                    onConfirm={() => onDelete(idx)}
-                    aria-label={`Delete query with title "${annotation.name}"`}
-                  />
+                  {!annotation.builtIn && (
+                    <DeleteButton
+                      size="sm"
+                      onConfirm={() => onDelete(idx)}
+                      aria-label={`Delete query with title "${annotation.name}"`}
+                    />
+                  )}
                 </td>
               </tr>
             ))}
diff --git a/public/app/features/dashboard/components/DashboardSettings/AnnotationsSettings.test.tsx b/public/app/features/dashboard/components/DashboardSettings/AnnotationsSettings.test.tsx
index a12eda258b9..7c4cd7f208a 100644
--- a/public/app/features/dashboard/components/DashboardSettings/AnnotationsSettings.test.tsx
+++ b/public/app/features/dashboard/components/DashboardSettings/AnnotationsSettings.test.tsx
@@ -230,11 +230,23 @@ describe('AnnotationsSettings', () => {
   });
 
   test('Deleting annotation', async () => {
-    setup(dashboard, 0);
+    dashboard.annotations.list = [
+      ...dashboard.annotations.list,
+      {
+        builtIn: 0,
+        datasource: { uid: 'uid3', type: 'prometheus' },
+        enable: true,
+        hide: true,
+        iconColor: 'rgba(0, 211, 255, 1)',
+        name: 'Annotation 2',
+        type: 'dashboard',
+      },
+    ];
+    setup(dashboard, 1); // Edit the not built-in annotations
 
     await userEvent.click(screen.getByRole('button', { name: 'Delete' }));
 
     expect(locationService.getSearchObject().editIndex).toBe(undefined);
-    expect(dashboard.annotations.list.length).toBe(0);
+    expect(dashboard.annotations.list.length).toBe(1); // started with two
   });
 });
diff --git a/public/app/features/dashboard/state/DashboardModel.ts b/public/app/features/dashboard/state/DashboardModel.ts
index 86a16b949f1..de94075045f 100644
--- a/public/app/features/dashboard/state/DashboardModel.ts
+++ b/public/app/features/dashboard/state/DashboardModel.ts
@@ -1114,10 +1114,14 @@ export class DashboardModel implements TimeModel {
   }
 
   canAddAnnotations() {
-    // If RBAC is enabled there are additional conditions to check.
-    const canAdd = !contextSrv.accessControlEnabled() || Boolean(this.meta.annotationsPermissions?.dashboard.canAdd);
+    // When the builtin annotations are disabled, we should not add any in the UI
+    const found = this.annotations.list.find((item) => item.builtIn === 1);
+    if (found?.enable === false || !this.canEditDashboard()) {
+      return false;
+    }
 
-    return this.canEditDashboard() && canAdd;
+    // If RBAC is enabled there are additional conditions to check.
+    return !contextSrv.accessControlEnabled() || Boolean(this.meta.annotationsPermissions?.dashboard.canAdd);
   }
 
   canEditDashboard() {