diff --git a/e2e/various-suite/verify-i18n.spec.ts b/e2e/various-suite/verify-i18n.spec.ts
index 3de37d5d863..319a2d254cf 100644
--- a/e2e/various-suite/verify-i18n.spec.ts
+++ b/e2e/various-suite/verify-i18n.spec.ts
@@ -38,22 +38,33 @@ describe('Verify i18n', () => {
   });
 
   // map between languages in the language picker and the corresponding translation of the 'Language' label
-  const languageMap: Record<string, string> = {
-    Deutsch: 'Sprache',
-    English: 'Language',
-    Español: 'Idioma',
-    Français: 'Langue',
-    'Português Brasileiro': 'Idioma',
-    '中文（简体）': '语言',
+  // const languageMap: Record<string, string> = {
+  //   Deutsch: 'Sprache',
+  //   English: 'Language',
+  //   Español: 'Idioma',
+  //   Français: 'Langue',
+  //   'Português Brasileiro': 'Idioma',
+  //   '中文（简体）': '语言',
+  // };
+
+  // map between languages in the weekstart picker and the corresponding translation of the 'Week Start' label
+  const weekStartMap: Record<string, string> = {
+    Deutsch: 'Wochenbeginn',
+    English: 'Week start',
+    Español: 'Inicio de la semana',
+    Français: 'Début de la semaine',
+    'Português Brasileiro': 'Início da semana',
+    '中文（简体）': '每周开始日',
   };
 
   // basic test which loops through the defined languages in the picker
   // and verifies that the corresponding label is translated correctly
   it('loads all the languages correctly', () => {
     cy.visit('/profile');
-    const LANGUAGE_SELECTOR = '[id="locale-select"]';
-
-    cy.wrap(Object.entries(languageMap)).each(([language, label]: [string, string]) => {
+    const LANGUAGE_SELECTOR = '[id="language-preference-select"]';
+    //TODO ckeck translations using language label when its translations get updated
+    // Checking the Week start label instead
+    cy.wrap(Object.entries(weekStartMap)).each(([language, label]: [string, string]) => {
       cy.get(LANGUAGE_SELECTOR).should('not.be.disabled');
       cy.get(LANGUAGE_SELECTOR).click();
       cy.get(LANGUAGE_SELECTOR).clear().type(language).type('{downArrow}{enter}');
diff --git a/public/app/core/components/SharedPreferences/SharedPreferences.tsx b/public/app/core/components/SharedPreferences/SharedPreferences.tsx
index 373ad066648..2cd7ca041e9 100644
--- a/public/app/core/components/SharedPreferences/SharedPreferences.tsx
+++ b/public/app/core/components/SharedPreferences/SharedPreferences.tsx
@@ -24,6 +24,7 @@ import {
 import { DashboardPicker } from 'app/core/components/Select/DashboardPicker';
 import { t, Trans } from 'app/core/internationalization';
 import { LANGUAGES, PSEUDO_LOCALE } from 'app/core/internationalization/constants';
+import { LOCALES } from 'app/core/internationalization/locales';
 import { PreferencesService } from 'app/core/services/PreferencesService';
 import { changeTheme } from 'app/core/services/theme';
 
@@ -39,7 +40,6 @@ export interface Props {
 export type State = UserPreferencesDTO & {
   isLoading: boolean;
 };
-
 function getLanguageOptions(): ComboboxOption[] {
   const languageOptions = LANGUAGES.map((v) => ({
     value: v.code,
@@ -67,9 +67,29 @@ function getLanguageOptions(): ComboboxOption[] {
   return options;
 }
 
+function getLocaleOptions(): ComboboxOption[] {
+  const localeOptions = LOCALES.map((v) => ({
+    value: v.code,
+    label: v.name,
+  })).sort((a, b) => {
+    return a.label.localeCompare(b.label);
+  });
+
+  const options = [
+    {
+      value: '',
+      label: t('common.locale.default', 'Default'),
+    },
+    ...localeOptions,
+  ];
+  return options;
+}
+
 export class SharedPreferences extends PureComponent<Props, State> {
   service: PreferencesService;
   themeOptions: ComboboxOption[];
+  languageOptions: ComboboxOption[];
+  localeOptions: ComboboxOption[];
 
   constructor(props: Props) {
     super(props);
@@ -81,17 +101,22 @@ export class SharedPreferences extends PureComponent<Props, State> {
       timezone: '',
       weekStart: '',
       language: '',
+      locale: '',
       queryHistory: { homeTab: '' },
       navbar: { bookmarkUrls: [] },
     };
 
     const themes = getSelectableThemes();
 
+    // Options are translated, so must be called after init but call them
+    // in constructor to avoid memo-break of array changing every render
     this.themeOptions = themes.map((theme) => ({
       value: theme.id,
       label: getTranslatedThemeName(theme),
       group: theme.isExtra ? t('shared-preferences.theme.experimental', 'Experimental') : undefined,
     }));
+    this.languageOptions = getLanguageOptions();
+    this.localeOptions = getLocaleOptions();
 
     // Add default option
     this.themeOptions.unshift({ value: '', label: t('shared-preferences.theme.default-label', 'Default') });
@@ -110,6 +135,7 @@ export class SharedPreferences extends PureComponent<Props, State> {
       timezone: prefs.timezone,
       weekStart: prefs.weekStart,
       language: prefs.language,
+      locale: prefs.locale,
       queryHistory: prefs.queryHistory,
       navbar: prefs.navbar,
     });
@@ -120,13 +146,22 @@ export class SharedPreferences extends PureComponent<Props, State> {
     const confirmationResult = this.props.onConfirm ? await this.props.onConfirm() : true;
 
     if (confirmationResult) {
-      const { homeDashboardUID, theme, timezone, weekStart, language, queryHistory, navbar } = this.state;
+      const { homeDashboardUID, theme, timezone, weekStart, language, locale, queryHistory, navbar } = this.state;
       reportInteraction('grafana_preferences_save_button_clicked', {
         preferenceType: this.props.preferenceType,
         theme,
         language,
       });
-      await this.service.update({ homeDashboardUID, theme, timezone, weekStart, language, queryHistory, navbar });
+      await this.service.update({
+        homeDashboardUID,
+        theme,
+        timezone,
+        weekStart,
+        language,
+        locale,
+        queryHistory,
+        navbar,
+      });
       window.location.reload();
     }
   };
@@ -167,11 +202,19 @@ export class SharedPreferences extends PureComponent<Props, State> {
     });
   };
 
+  onLocaleChanged = (locale: string) => {
+    this.setState({ locale });
+
+    reportInteraction('grafana_preferences_locale_changed', {
+      toLocale: locale,
+      preferenceType: this.props.preferenceType,
+    });
+  };
+
   render() {
-    const { theme, timezone, weekStart, homeDashboardUID, language, isLoading } = this.state;
+    const { theme, timezone, weekStart, homeDashboardUID, language, isLoading, locale } = this.state;
     const { disabled } = this.props;
     const styles = getStyles();
-    const languages = getLanguageOptions();
     const currentThemeOption = this.themeOptions.find((x) => x.value === theme) ?? this.themeOptions[0];
 
     return (
@@ -257,23 +300,50 @@ export class SharedPreferences extends PureComponent<Props, State> {
             loading={isLoading}
             disabled={isLoading}
             label={
-              <Label htmlFor="locale-select">
+              <Label htmlFor="language-preference-select">
                 <span className={styles.labelText}>
-                  <Trans i18nKey="shared-preferences.fields.locale-label">Language</Trans>
+                  <Trans i18nKey="shared-preferences.fields.language-preference-label">Language</Trans>
                 </span>
-                <FeatureBadge featureState={FeatureState.beta} />
+                <FeatureBadge featureState={FeatureState.preview} />
               </Label>
             }
             data-testid="User preferences language drop down"
           >
             <Combobox
-              value={languages.find((lang) => lang.value === language)?.value || ''}
+              value={this.languageOptions.find((lang) => lang.value === language)?.value || ''}
               onChange={(lang: ComboboxOption | null) => this.onLanguageChanged(lang?.value ?? '')}
-              options={languages}
-              placeholder={t('shared-preferences.fields.locale-placeholder', 'Choose language')}
-              id="locale-select"
+              options={this.languageOptions}
+              placeholder={t('shared-preferences.fields.language-preference-placeholder', 'Choose language')}
+              id="language-preference-select"
             />
           </Field>
+          {config.featureToggles.localeFormatPreference && (
+            <Field
+              loading={isLoading}
+              disabled={isLoading}
+              label={
+                <Label htmlFor="locale-preference">
+                  <span className={styles.labelText}>
+                    <Trans i18nKey="shared-preferences.fields.locale-preference-label">Region format</Trans>
+                  </span>
+                  <FeatureBadge featureState={FeatureState.experimental} />
+                </Label>
+              }
+              description={t(
+                'shared-preferences.fields.locale-preference-description',
+                'Choose your region to see the corresponding date, time, and number format'
+              )}
+              data-testid="User preferences locale drop down"
+            >
+              <Combobox
+                value={this.localeOptions.find((loc) => loc.value === locale)?.value || ''}
+                onChange={(locale: ComboboxOption | null) => this.onLocaleChanged(locale?.value ?? '')}
+                options={this.localeOptions}
+                placeholder={t('shared-preferences.fields.locale-preference-placeholder', 'Choose region')}
+                id="locale-preference-select"
+              />
+            </Field>
+          )}
         </FieldSet>
         <Button type="submit" variant="primary" data-testid={selectors.components.UserProfile.preferencesSaveButton}>
           <Trans i18nKey="common.save">Save</Trans>
diff --git a/public/app/core/internationalization/locales.ts b/public/app/core/internationalization/locales.ts
new file mode 100644
index 00000000000..4e7ce32ed8a
--- /dev/null
+++ b/public/app/core/internationalization/locales.ts
@@ -0,0 +1,146 @@
+// List hard-coded locales from https://github.com/moment/moment/tree/develop/locale
+
+interface Locale {
+  name: string;
+  code: string;
+}
+
+// TODO re-check translations
+export const LOCALES: Locale[] = [
+  { name: 'Afrikaans', code: 'af' },
+  { name: 'العربية', code: 'ar' },
+  { name: 'العربية (الجزائر)', code: 'ar-dz' },
+  { name: 'العربية (الكويت)', code: 'ar-kw' },
+  { name: 'العربية (ليبيا)', code: 'ar-ly' },
+  { name: 'العربية (المغرب)', code: 'ar-ma' },
+  { name: 'العربية (فلسطين)', code: 'ar-ps' },
+  { name: 'العربية (السعودية)', code: 'ar-sa' },
+  { name: 'العربية (تونس)', code: 'ar-tn' },
+  { name: 'Azərbaycanca', code: 'az' },
+  { name: 'Беларуская', code: 'be' },
+  { name: 'български език', code: 'bg' },
+  { name: 'Bamanankan', code: 'bm' },
+  { name: 'Bengali', code: 'bn' }, // TODO translate : বাংলা ???
+  { name: 'Bengali (Bangladesh)', code: 'bn-bd' }, // TODO translate
+  { name: 'Tibetan', code: 'bo' }, // TODO translate
+  { name: 'Brezhoneg', code: 'br' },
+  { name: 'Босански', code: 'bs' },
+  { name: 'Catalán', code: 'ca' },
+  { name: 'Čeština', code: 'cs' },
+  { name: 'Cymraeg', code: 'cy' },
+  { name: 'Чӑвашла', code: 'cv' },
+  { name: 'Dansk', code: 'da' },
+  { name: 'Deutsch', code: 'de' },
+  { name: 'Deutsch (Österreich)', code: 'de-at' },
+  { name: 'Deutsch (Schweiz)', code: 'de-ch' },
+  { name: 'ދިވެހި', code: 'dv' },
+  { name: 'Ελληνικά', code: 'el' },
+  { name: 'English (Australia)', code: 'en-au' },
+  { name: 'English (Canada)', code: 'en-ca' },
+  { name: 'English (United Kingdom)', code: 'en-gb' },
+  { name: 'English (Ireland)', code: 'en-ie' },
+  { name: 'English (Israel)', code: 'en-il' },
+  { name: 'English (India)', code: 'en-in' },
+  { name: 'English (New Zealand)', code: 'en-nz' },
+  { name: 'English (Singapore)', code: 'en-sg' },
+  { name: 'English (United States)', code: 'en' },
+  { name: 'Esperanto', code: 'eo' },
+  { name: 'Español', code: 'es' },
+  { name: 'Español (República Dominicana)', code: 'es-do' },
+  { name: 'Español (México)', code: 'es-mx' },
+  { name: 'Español (Estados Unidos)', code: 'es-us' },
+  { name: 'Eesti keel', code: 'et' },
+  { name: 'Euskara', code: 'eu' },
+  { name: 'فارسی', code: 'fa' },
+  { name: 'Filipino', code: 'fil' },
+  { name: 'Suomi', code: 'fi' },
+  { name: 'Føroyskt', code: 'fo' },
+  { name: 'Français', code: 'fr' },
+  { name: 'Français (Canada)', code: 'fr-ca' },
+  { name: 'Français (Suisse)', code: 'fr-ch' },
+  { name: 'Frisian', code: 'fy' }, // TODO translate
+  { name: 'Gaeilge', code: 'ga' },
+  { name: 'Gàidhlig', code: 'gd' },
+  { name: 'Galego', code: 'gl' },
+  { name: 'Konkani Devanagari', code: 'gom-deva' }, // TODO translate
+  { name: 'Konkani Latin', code: 'gom-latn' }, // TODO translate
+  { name: 'ગુજરાતી', code: 'gu' },
+  { name: 'עברית', code: 'he' },
+  { name: 'हिन्दी', code: 'hi' },
+  { name: 'Hrvatski', code: 'hr' },
+  { name: 'Magyar', code: 'hu' },
+  { name: 'Հայերեն', code: 'hy-am' },
+  { name: 'Bahasa Indonesia', code: 'id' },
+  { name: 'Íslenska', code: 'is' },
+  { name: 'Italiano', code: 'it' },
+  { name: 'Italiano (Switzerland)', code: 'it-ch' },
+  { name: '日本語', code: 'ja' },
+  { name: 'ꦧꦱꦗꦮ', code: 'jv' },
+  { name: 'ქართული', code: 'ka' },
+  { name: 'Қазақ Tілі', code: 'kk' },
+  { name: 'Cambodian', code: 'km' }, // TODO translate
+  { name: 'ಕನ್ನಡ', code: 'kn' },
+  { name: '한국어', code: 'ko' },
+  { name: 'Kurdish', code: 'ku' }, // TODO translate
+  { name: 'Northern Kurdish', code: 'ku' }, // TODO translate
+  { name: 'Кыргыз тили', code: 'ky' },
+  { name: 'Lëtzebuergesch', code: 'lb' },
+  { name: 'ພາສາລາວ', code: 'lo' },
+  { name: 'Lietuvių', code: 'lt' },
+  { name: 'latviešu', code: 'lv' },
+  { name: 'Mакедонски', code: 'mk' },
+  { name: 'മലയാളം', code: 'ml' },
+  { name: 'te Reo Māori', code: 'mi' },
+  { name: 'crnogorski', code: 'me' },
+  { name: 'मराठी', code: 'mr' },
+  { name: 'Bahasa Melayu', code: 'ms' },
+  { name: 'Malti', code: 'mt' },
+  { name: 'Монгол Хэл', code: 'mn' },
+  { name: 'Burmese', code: 'my' }, // TODO trasnlate: မြန်မာစာ ??
+  { name: 'Norwegian Bokmål', code: 'nb' }, // TODO translate
+  { name: 'नेपाली', code: 'ne' },
+  { name: 'Nederlands', code: 'nl' },
+  { name: 'Nederlands (België)', code: 'nl-be' },
+  { name: 'Ninorks', code: 'nn' }, //??
+  { name: 'Occitan (Lengadocian)', code: 'oc-lnc' },
+  { name: 'पंजाबी (ਭਾਰਤ)', code: 'pa-in' },
+  { name: 'Polski', code: 'pl' },
+  { name: 'Português', code: 'pt' },
+  { name: 'Português (Brasil)', code: 'pt-br' },
+  { name: 'Română', code: 'ro' },
+  { name: 'Русский', code: 'ru' },
+  { name: 'Nothern Sami', code: 'se' }, // TODO translate
+  { name: 'سنڌي', code: 'sd' },
+  { name: 'සිංහල', code: 'si' },
+  { name: 'Slovenčina', code: 'sk' },
+  { name: 'Slovenščina', code: 'sl' },
+  { name: 'Shqip', code: 'sq' },
+  { name: 'Српски', code: 'sr' },
+  { name: 'Serbian Cyrillic', code: 'sr-cyrl' }, // TODO translate
+  { name: 'siSwati', code: 'ss' },
+  { name: 'Kiswahili', code: 'sw' },
+  { name: 'Svenska', code: 'sv' },
+  { name: 'தமிழ்', code: 'ta' },
+  { name: 'తెలుగు', code: 'te' },
+  { name: 'Lia-Tetun', code: 'tet' },
+  { name: 'Тоҷикӣ', code: 'tg' },
+  { name: 'ภาษาไทย', code: 'th' },
+  { name: 'Türkmençe', code: 'tk' },
+  { name: 'Tagalog (Philippines)', code: 'tl-ph' }, // TODO translate
+  { name: 'tlhIngan Hol', code: 'tlh' },
+  { name: 'Türkçe', code: 'tr' },
+  { name: 'Talossan', code: 'tzl' }, // TODO translate
+  { name: 'أمازيغية أطلس الأوسط', code: 'tzm' },
+  { name: 'Central Atlas Tamazight Latin', code: 'tzm-latn' }, // TODO translate
+  { name: 'ئۇيغۇر تىلى', code: 'ug-cn' },
+  { name: 'Українська', code: 'uk' },
+  { name: 'اُردُو', code: 'ur' },
+  { name: 'Ўзбек', code: 'uz' },
+  { name: 'Uzbek (Latin)', code: 'uz-latn' }, // TODO translate
+  { name: 'tiếng Việt', code: 'vi' },
+  { name: 'Chinese (China)', code: 'zh-cn' }, // TODO translate
+  { name: 'Chinese (Hong Kong)', code: 'zh-hk' }, // TODO translate
+  { name: 'Chinese (Macau)', code: 'zh-mo' }, // TODO translate
+  { name: 'Chinese (Taiwan)', code: 'zh-tw' }, // TODO translate
+  { name: 'Èdè Yorùbá', code: 'yo-ng' },
+];
diff --git a/public/locales/en-US/grafana.json b/public/locales/en-US/grafana.json
index 468ef976a60..d0892ab1856 100644
--- a/public/locales/en-US/grafana.json
+++ b/public/locales/en-US/grafana.json
@@ -7427,8 +7427,11 @@
     "fields": {
       "home-dashboard-label": "Home Dashboard",
       "home-dashboard-placeholder": "Default dashboard",
-      "locale-label": "Language",
-      "locale-placeholder": "Choose language",
+      "language-preference-label": "Language",
+      "language-preference-placeholder": "Choose language",
+      "locale-preference-description": "Choose your region to see the corresponding date, time, and number format",
+      "locale-preference-label": "Region format",
+      "locale-preference-placeholder": "Choose region",
       "theme-description": "Enjoying the experimental themes? Tell us what you'd like to see <2>here.</2>",
       "theme-label": "Interface theme",
       "week-start-label": "Week start"