diff --git a/public/app/features/plugins/admin/components/InstallControls/InstallControlsButton.test.tsx b/public/app/features/plugins/admin/components/InstallControls/InstallControlsButton.test.tsx
index 77bdb1f096e..1da1da10d29 100644
--- a/public/app/features/plugins/admin/components/InstallControls/InstallControlsButton.test.tsx
+++ b/public/app/features/plugins/admin/components/InstallControls/InstallControlsButton.test.tsx
@@ -168,4 +168,79 @@ describe('InstallControlsButton', () => {
       expect(button).toBeEnabled();
     });
   });
+
+  describe('uninstall button on prem', () => {
+    const store = configureStore({
+      plugins: getPluginsStateMock([]),
+    });
+
+    it('should be disabled when is Installing', () => {
+      store.dispatch({ type: 'plugins/uninstall/pending' });
+      render(
+        <TestProvider store={store}>
+          <InstallControlsButton plugin={{ ...plugin }} pluginStatus={PluginStatus.UNINSTALL} />
+        </TestProvider>
+      );
+      const button = screen.getByText('Uninstalling').closest('button');
+      expect(button).toBeDisabled();
+    });
+
+    it('should be enabled when it is not Installing', () => {
+      store.dispatch({ type: 'plugins/uninstall/fulfilled', payload: { id: '', changes: {} } });
+      render(
+        <TestProvider store={store}>
+          <InstallControlsButton plugin={{ ...plugin }} pluginStatus={PluginStatus.UNINSTALL} />
+        </TestProvider>
+      );
+      const button = screen.getByText('Uninstall').closest('button');
+      expect(button).toBeEnabled();
+    });
+  });
+
+  describe('uninstall button on managed instance', () => {
+    const oldFeatureTogglesManagedPluginsInstall = config.featureToggles.managedPluginsInstall;
+    const oldPluginAdminExternalManageEnabled = config.pluginAdminExternalManageEnabled;
+
+    beforeAll(() => {
+      config.featureToggles.managedPluginsInstall = true;
+      config.pluginAdminExternalManageEnabled = true;
+    });
+
+    afterAll(() => {
+      config.featureToggles.managedPluginsInstall = oldFeatureTogglesManagedPluginsInstall;
+      config.pluginAdminExternalManageEnabled = oldPluginAdminExternalManageEnabled;
+    });
+
+    const store = configureStore({
+      plugins: getPluginsStateMock([]),
+    });
+
+    it('should be disabled when isInstalling=false but isUninstallingFromInstance=true', () => {
+      store.dispatch({ type: 'plugins/uninstall/fulfilled', payload: { id: '', changes: {} } });
+      render(
+        <TestProvider store={store}>
+          <InstallControlsButton
+            plugin={{ ...plugin, isUninstallingFromInstance: true }}
+            pluginStatus={PluginStatus.UNINSTALL}
+          />
+        </TestProvider>
+      );
+      const button = screen.getByText('Uninstall').closest('button');
+      expect(button).toBeDisabled();
+    });
+
+    it('should be enabled when isInstalling=false and isUninstallingFromInstance=false', () => {
+      store.dispatch({ type: 'plugins/uninstall/fulfilled', payload: { id: '', changes: {} } });
+      render(
+        <TestProvider store={store}>
+          <InstallControlsButton
+            plugin={{ ...plugin, isUninstallingFromInstance: false }}
+            pluginStatus={PluginStatus.UNINSTALL}
+          />
+        </TestProvider>
+      );
+      const button = screen.getByText('Uninstall').closest('button');
+      expect(button).toBeEnabled();
+    });
+  });
 });
diff --git a/public/app/features/plugins/admin/components/InstallControls/InstallControlsButton.tsx b/public/app/features/plugins/admin/components/InstallControls/InstallControlsButton.tsx
index 68411e2fbdd..5ea2afbc7db 100644
--- a/public/app/features/plugins/admin/components/InstallControls/InstallControlsButton.tsx
+++ b/public/app/features/plugins/admin/components/InstallControls/InstallControlsButton.tsx
@@ -114,6 +114,11 @@ export function InstallControlsButton({
   };
 
   if (pluginStatus === PluginStatus.UNINSTALL) {
+    const disableUninstall =
+      config.pluginAdminExternalManageEnabled && configCore.featureToggles.managedPluginsInstall
+        ? plugin.isUninstallingFromInstance
+        : isUninstalling;
+
     return (
       <>
         <ConfirmModal
@@ -126,7 +131,7 @@ export function InstallControlsButton({
           onDismiss={hideConfirmModal}
         />
         <HorizontalGroup align="flex-start" width="auto" height="auto">
-          <Button variant="destructive" disabled={isUninstalling} onClick={showConfirmModal}>
+          <Button variant="destructive" disabled={disableUninstall} onClick={showConfirmModal}>
             {uninstallBtnText}
           </Button>
         </HorizontalGroup>
diff --git a/public/app/features/plugins/admin/helpers.ts b/public/app/features/plugins/admin/helpers.ts
index 25f32871f23..86c0c92b3e1 100644
--- a/public/app/features/plugins/admin/helpers.ts
+++ b/public/app/features/plugins/admin/helpers.ts
@@ -60,6 +60,8 @@ export function mergeLocalsAndRemotes({
           instancesMap.has(remotePlugin.slug) &&
           catalogPlugin.hasUpdate &&
           catalogPlugin.installedVersion !== instancePlugin?.version;
+
+        catalogPlugin.isUninstallingFromInstance = Boolean(localCounterpart) && !instancesMap.has(remotePlugin.slug);
       }
 
       catalogPlugins.push(catalogPlugin);
diff --git a/public/app/features/plugins/admin/types.ts b/public/app/features/plugins/admin/types.ts
index 833cb1bc07f..7c54128e001 100644
--- a/public/app/features/plugins/admin/types.ts
+++ b/public/app/features/plugins/admin/types.ts
@@ -62,6 +62,7 @@ export interface CatalogPlugin extends WithAccessControlMetadata {
   // instance plugins may not be fully installed, which means a new instance
   // running the plugin didn't started yet
   isFullyInstalled?: boolean;
+  isUninstallingFromInstance?: boolean;
   isUpdatingFromInstance?: boolean;
   iam?: IdentityAccessManagement;
 }