diff --git a/pkg/apimachinery/errutil/errors.go b/pkg/apimachinery/errutil/errors.go
index e8bc0e4b0f2..d91749496b9 100644
--- a/pkg/apimachinery/errutil/errors.go
+++ b/pkg/apimachinery/errutil/errors.go
@@ -4,6 +4,7 @@ import (
 	"encoding/json"
 	"errors"
 	"fmt"
+	"strings"
 
 	errorsK8s "k8s.io/apimachinery/pkg/api/errors"
 	metav1 "k8s.io/apimachinery/pkg/apis/meta/v1"
@@ -356,6 +357,9 @@ type Error struct {
 	LogLevel LogLevel
 	// Source identifies from where the error originates.
 	Source Source
+	// WithContactSupportErrorMessage indicates whether we should append a message
+	// to the public message advising the user to contact support
+	WithContactSupportErrorMessage bool
 }
 
 // MarshalJSON returns an error, we do not want raw [Error]s being
@@ -458,6 +462,13 @@ func (e Error) Public() PublicError {
 		}
 	}
 
+	if e.WithContactSupportErrorMessage {
+		if !strings.HasSuffix(message, ".") {
+			message += "."
+		}
+		message += " Please contact support if the issue persists."
+	}
+
 	return PublicError{
 		StatusCode: e.Reason.Status().HTTPStatus(),
 		MessageID:  e.MessageID,
@@ -470,3 +481,9 @@ func (e Error) Public() PublicError {
 func (p PublicError) Error() string {
 	return fmt.Sprintf("[%s] %s", p.MessageID, p.Message)
 }
+
+// WithSupportContact creates a new Error with WithContactSupportErrorMessage set to true
+func (e Error) WithContactSupportMessage() Error {
+	e.WithContactSupportErrorMessage = true
+	return e
+}
diff --git a/pkg/apimachinery/errutil/errors_test.go b/pkg/apimachinery/errutil/errors_test.go
index 5e49827a32b..bd54a8730d5 100644
--- a/pkg/apimachinery/errutil/errors_test.go
+++ b/pkg/apimachinery/errutil/errors_test.go
@@ -4,6 +4,7 @@ import (
 	"errors"
 	"fmt"
 	"reflect"
+	"strings"
 	"testing"
 
 	"github.com/stretchr/testify/assert"
@@ -72,3 +73,54 @@ func TestBase_Is(t *testing.T) {
 		})
 	}
 }
+
+func TestError_WithContactSupportMessage(t *testing.T) {
+	tests := []struct {
+		name           string
+		error          Error
+		expectedSuffix string
+	}{
+		{
+			name: "should append contact support message when WithContactSupportMessage is called",
+			error: Error{
+				Reason:        StatusInternal,
+				MessageID:     "test.error",
+				LogMessage:    "test error message",
+				PublicMessage: "Something went wrong",
+			}.WithContactSupportMessage(),
+			expectedSuffix: "Please contact support if the issue persists.",
+		},
+		{
+			name: "should not append contact support message when WithContactSupportMessage is not called",
+			error: Error{
+				Reason:        StatusInternal,
+				MessageID:     "test.error",
+				LogMessage:    "test error message",
+				PublicMessage: "Something went wrong",
+			},
+			expectedSuffix: "",
+		},
+		{
+			name: "should handle message with existing period",
+			error: Error{
+				Reason:        StatusInternal,
+				MessageID:     "test.error",
+				LogMessage:    "test error message",
+				PublicMessage: "Something went wrong.",
+			}.WithContactSupportMessage(),
+			expectedSuffix: "Please contact support if the issue persists.",
+		},
+	}
+
+	for _, tt := range tests {
+		t.Run(tt.name, func(t *testing.T) {
+			public := tt.error.Public()
+			message := public.Message
+			if tt.expectedSuffix != "" {
+				assert.True(t, strings.HasSuffix(message, tt.expectedSuffix))
+			} else {
+				assert.NotContains(t, message, "Please contact support if the issue persists.")
+			}
+		})
+	}
+}
diff --git a/pkg/plugins/backendplugin/grpcplugin/client_v2.go b/pkg/plugins/backendplugin/grpcplugin/client_v2.go
index 78d7b0d6dcc..089d8f42dd0 100644
--- a/pkg/plugins/backendplugin/grpcplugin/client_v2.go
+++ b/pkg/plugins/backendplugin/grpcplugin/client_v2.go
@@ -14,6 +14,7 @@ import (
 	"google.golang.org/grpc/codes"
 	"google.golang.org/grpc/status"
 
+	"github.com/grafana/grafana/pkg/extensions/datasource/dsrunner/pluginmetrics"
 	"github.com/grafana/grafana/pkg/plugins"
 	"github.com/grafana/grafana/pkg/plugins/backendplugin/pluginextensionv2"
 	"github.com/grafana/grafana/pkg/plugins/log"
@@ -173,7 +174,13 @@ func (c *ClientV2) QueryData(ctx context.Context, req *backend.QueryDataRequest)
 		}
 
 		if status.Code(err) == codes.Unavailable {
-			return nil, plugins.ErrPluginGrpcConnectionUnavailableBase.Errorf("%v", err)
+			connectionErr := plugins.ErrPluginGrpcConnectionUnavailableBase.Errorf("%v", err)
+			// Check if the plugin is running in a cloud environment
+			_, hasStackId := pluginmetrics.StackIDFromContext(ctx)
+			if hasStackId {
+				return nil,connectionErr.WithContactSupportMessage()
+			}
+			return nil, connectionErr
 		}
 
 		if status.Code(err) == codes.ResourceExhausted {