diff --git a/pkg/services/sqlstore/migrator/dialect.go b/pkg/services/sqlstore/migrator/dialect.go
index c5a0128450d..f68a1b6672d 100644
--- a/pkg/services/sqlstore/migrator/dialect.go
+++ b/pkg/services/sqlstore/migrator/dialect.go
@@ -27,7 +27,10 @@ type Dialect interface {
 	ShowCreateNull() bool
 	SQLType(col *Column) string
 	SupportEngine() bool
+	// Deprecated. This doesn't work correctly for all databases.
 	LikeStr() string
+	// LikeOperator returns SQL snippet and query parameter for case-insensitive LIKE operation, with optional wildcards (%) before/after the pattern.
+	LikeOperator(column string, wildcardBefore bool, pattern string, wildcardAfter bool) (string, string)
 	Default(col *Column) string
 	// BooleanValue can be used as an argument in SELECT or INSERT statements. For constructing
 	// raw SQL queries, please use BooleanStr instead.
@@ -153,6 +156,17 @@ func (b *BaseDialect) LikeStr() string {
 	return "LIKE"
 }
 
+func (b *BaseDialect) LikeOperator(column string, wildcardBefore bool, pattern string, wildcardAfter bool) (string, string) {
+	param := pattern
+	if wildcardBefore {
+		param = "%" + param
+	}
+	if wildcardAfter {
+		param = param + "%"
+	}
+	return fmt.Sprintf("%s LIKE ?", column), param
+}
+
 func (b *BaseDialect) OrStr() string {
 	return "OR"
 }
diff --git a/pkg/services/sqlstore/migrator/postgres_dialect.go b/pkg/services/sqlstore/migrator/postgres_dialect.go
index 9d343cc2f8f..47a0f2707b5 100644
--- a/pkg/services/sqlstore/migrator/postgres_dialect.go
+++ b/pkg/services/sqlstore/migrator/postgres_dialect.go
@@ -35,6 +35,17 @@ func (db *PostgresDialect) LikeStr() string {
 	return "ILIKE"
 }
 
+func (db *PostgresDialect) LikeOperator(column string, wildcardBefore bool, pattern string, wildcardAfter bool) (string, string) {
+	param := pattern
+	if wildcardBefore {
+		param = "%" + param
+	}
+	if wildcardAfter {
+		param = param + "%"
+	}
+	return fmt.Sprintf("%s ILIKE ?", column), param
+}
+
 func (db *PostgresDialect) AutoIncrStr() string {
 	return ""
 }
diff --git a/pkg/services/sqlstore/migrator/spanner_dialect.go b/pkg/services/sqlstore/migrator/spanner_dialect.go
index b4c83bdc07a..db1a1b4bc9b 100644
--- a/pkg/services/sqlstore/migrator/spanner_dialect.go
+++ b/pkg/services/sqlstore/migrator/spanner_dialect.go
@@ -7,6 +7,7 @@ import (
 	"encoding/json"
 	"errors"
 	"fmt"
+	"strings"
 	"time"
 
 	"cloud.google.com/go/spanner"
@@ -44,6 +45,18 @@ func NewSpannerDialect() Dialect {
 func (s *SpannerDialect) AutoIncrStr() string      { return s.d.AutoIncrStr() }
 func (s *SpannerDialect) Quote(name string) string { return s.d.Quote(name) }
 func (s *SpannerDialect) SupportEngine() bool      { return s.d.SupportEngine() }
+
+func (s *SpannerDialect) LikeOperator(column string, wildcardBefore bool, pattern string, wildcardAfter bool) (string, string) {
+	param := strings.ToLower(pattern)
+	if wildcardBefore {
+		param = "%" + param
+	}
+	if wildcardAfter {
+		param = param + "%"
+	}
+	return fmt.Sprintf("LOWER(%s) LIKE ?", column), param
+}
+
 func (s *SpannerDialect) IndexCheckSQL(tableName, indexName string) (string, []any) {
 	return s.d.IndexCheckSql(tableName, indexName)
 }
diff --git a/pkg/services/user/userimpl/store.go b/pkg/services/user/userimpl/store.go
index a5216b04e7a..e8d65d5f820 100644
--- a/pkg/services/user/userimpl/store.go
+++ b/pkg/services/user/userimpl/store.go
@@ -2,15 +2,11 @@ package userimpl
 
 import (
 	"context"
-	"errors"
 	"fmt"
 	"strconv"
 	"strings"
 	"time"
 
-	"github.com/go-sql-driver/mysql"
-	"github.com/mattn/go-sqlite3"
-
 	"github.com/grafana/grafana/pkg/events"
 	"github.com/grafana/grafana/pkg/infra/db"
 	"github.com/grafana/grafana/pkg/infra/log"
@@ -76,8 +72,9 @@ func (ss *sqlStore) Insert(ctx context.Context, cmd *user.User) (int64, error) {
 		})
 		return nil
 	})
+
 	if err != nil {
-		return 0, handleSQLError(err)
+		return 0, handleSQLError(ss.dialect, err)
 	}
 
 	return cmd.ID, nil
@@ -482,8 +479,6 @@ func (ss *sqlStore) Search(ctx context.Context, query *user.SearchUsersQuery) (*
 		Users: make([]*user.UserSearchHitDTO, 0),
 	}
 	err := ss.db.WithDbSession(ctx, func(dbSess *db.Session) error {
-		queryWithWildcards := "%" + query.Query + "%"
-
 		whereConditions := make([]string, 0)
 		whereParams := make([]any, 0)
 		sess := dbSess.Table("user").Alias("u")
@@ -512,8 +507,11 @@ func (ss *sqlStore) Search(ctx context.Context, query *user.SearchUsersQuery) (*
 		whereParams = append(whereParams, acFilter.Args...)
 
 		if query.Query != "" {
-			whereConditions = append(whereConditions, "(email "+ss.dialect.LikeStr()+" ? OR name "+ss.dialect.LikeStr()+" ? OR login "+ss.dialect.LikeStr()+" ?)")
-			whereParams = append(whereParams, queryWithWildcards, queryWithWildcards, queryWithWildcards)
+			emailSql, emailArg := ss.dialect.LikeOperator("email", true, query.Query, true)
+			nameSql, nameArg := ss.dialect.LikeOperator("name", true, query.Query, true)
+			loginSql, loginArg := ss.dialect.LikeOperator("login", true, query.Query, true)
+			whereConditions = append(whereConditions, fmt.Sprintf("(%s OR %s OR %s)", emailSql, nameSql, loginSql))
+			whereParams = append(whereParams, emailArg, nameArg, loginArg)
 		}
 
 		if query.IsDisabled != nil {
@@ -606,29 +604,9 @@ func setOptional[T any](v *T, add func(v T)) {
 	}
 }
 
-func handleSQLError(err error) error {
-	if isUniqueConstraintError(err) {
+func handleSQLError(dialect migrator.Dialect, err error) error {
+	if dialect.IsUniqueConstraintViolation(err) {
 		return user.ErrUserAlreadyExists
 	}
 	return err
 }
-
-func isUniqueConstraintError(err error) bool {
-	// check mysql error code
-	var me *mysql.MySQLError
-	if errors.As(err, &me) && me.Number == 1062 {
-		return true
-	}
-
-	// for postgres we check the error message
-	if strings.Contains(err.Error(), "duplicate key value") {
-		return true
-	}
-
-	var se sqlite3.Error
-	if errors.As(err, &se) && se.ExtendedCode == sqlite3.ErrConstraintUnique {
-		return true
-	}
-
-	return false
-}