diff --git a/packages/grafana-ui/src/components/Combobox/MultiCombobox.tsx b/packages/grafana-ui/src/components/Combobox/MultiCombobox.tsx
index 2dfc72663b6..e511ee0b032 100644
--- a/packages/grafana-ui/src/components/Combobox/MultiCombobox.tsx
+++ b/packages/grafana-ui/src/components/Combobox/MultiCombobox.tsx
@@ -9,6 +9,7 @@ import { Box } from '../Layout/Box/Box';
 import { Stack } from '../Layout/Stack/Stack';
 import { Portal } from '../Portal/Portal';
 import { ScrollContainer } from '../ScrollContainer/ScrollContainer';
+import { Spinner } from '../Spinner/Spinner';
 import { Text } from '../Text/Text';
 import { Tooltip } from '../Tooltip';
 
@@ -34,7 +35,7 @@ interface MultiComboboxBaseProps<T extends string | number> extends Omit<Combobo
 export type MultiComboboxProps<T extends string | number> = MultiComboboxBaseProps<T> & AutoSizeConditionals;
 
 export const MultiCombobox = <T extends string | number>(props: MultiComboboxProps<T>) => {
-  const { options, placeholder, onChange, value, width } = props;
+  const { options, placeholder, onChange, value, width, invalid, loading, disabled } = props;
   const isAsync = typeof options === 'function';
 
   const selectedItems = useMemo(() => {
@@ -59,9 +60,13 @@ export const MultiCombobox = <T extends string | number>(props: MultiComboboxPro
 
   const { inputRef: containerRef, floatingRef, floatStyles, scrollRef } = useComboboxFloat(items, isOpen);
 
-  const multiStyles = useStyles2(getMultiComboboxStyles, isOpen);
+  const multiStyles = useStyles2(getMultiComboboxStyles, isOpen, invalid, disabled);
 
-  const { measureRef, suffixMeasureRef, shownItems } = useMeasureMulti(selectedItems, width);
+  const { measureRef, counterMeasureRef, suffixMeasureRef, shownItems } = useMeasureMulti(
+    selectedItems,
+    width,
+    disabled
+  );
 
   const isOptionSelected = useCallback(
     (item: ComboboxOption<T>) => selectedItems.some((opt) => opt.value === item.value),
@@ -157,13 +162,14 @@ export const MultiCombobox = <T extends string | number>(props: MultiComboboxPro
     <div ref={containerRef}>
       <div
         style={{ width: width === 'auto' ? undefined : width }}
-        className={multiStyles.wrapper}
+        className={cx(multiStyles.wrapper, { [multiStyles.disabled]: disabled })}
         ref={measureRef}
-        onClick={() => selectedItems.length > 0 && setIsOpen(!isOpen)}
+        onClick={() => !disabled && selectedItems.length > 0 && setIsOpen(!isOpen)}
       >
         <span className={multiStyles.pillWrapper}>
           {visibleItems.map((item, index) => (
             <ValuePill
+              disabled={disabled}
               onRemove={() => {
                 removeSelectedItem(item);
               }}
@@ -174,7 +180,7 @@ export const MultiCombobox = <T extends string | number>(props: MultiComboboxPro
             </ValuePill>
           ))}
           {selectedItems.length > shownItems && !isOpen && (
-            <Box display="flex" direction="row" marginLeft={0.5} gap={1} ref={suffixMeasureRef}>
+            <Box display="flex" direction="row" marginLeft={0.5} gap={1} ref={counterMeasureRef}>
               {/* eslint-disable-next-line @grafana/no-untranslated-strings */}
               <Text>...</Text>
               <Tooltip
@@ -197,12 +203,18 @@ export const MultiCombobox = <T extends string | number>(props: MultiComboboxPro
             })}
             {...getInputProps(
               getDropdownProps({
+                disabled,
                 preventKeyAction: isOpen,
                 placeholder: selectedItems.length > 0 ? undefined : placeholder,
                 onFocus: () => setIsOpen(true),
               })
             )}
           />
+          {loading && (
+            <div className={multiStyles.suffix} ref={suffixMeasureRef}>
+              <Spinner inline={true} />
+            </div>
+          )}
         </span>
       </div>
       <Portal>
diff --git a/packages/grafana-ui/src/components/Combobox/ValuePill.tsx b/packages/grafana-ui/src/components/Combobox/ValuePill.tsx
index 789436938b8..96809d281b7 100644
--- a/packages/grafana-ui/src/components/Combobox/ValuePill.tsx
+++ b/packages/grafana-ui/src/components/Combobox/ValuePill.tsx
@@ -9,28 +9,35 @@ import { IconButton } from '../IconButton/IconButton';
 interface ValuePillProps {
   children: string;
   onRemove: () => void;
+  disabled?: boolean;
 }
 
-export const ValuePill = forwardRef<HTMLSpanElement, ValuePillProps>(({ children, onRemove, ...rest }, ref) => {
-  const styles = useStyles2(getValuePillStyles);
-  return (
-    <span className={styles.wrapper} {...rest} ref={ref}>
-      <span className={styles.text}>{children}</span>
-      <span className={styles.separator} />
-      <IconButton
-        name="times"
-        size="md"
-        aria-label={`Remove ${children}`}
-        onClick={(e) => {
-          e.stopPropagation();
-          onRemove();
-        }}
-      />
-    </span>
-  );
-});
+export const ValuePill = forwardRef<HTMLSpanElement, ValuePillProps>(
+  ({ children, onRemove, disabled, ...rest }, ref) => {
+    const styles = useStyles2(getValuePillStyles, disabled);
+    return (
+      <span className={styles.wrapper} {...rest} ref={ref}>
+        <span className={styles.text}>{children}</span>
+        {!disabled && (
+          <>
+            <span className={styles.separator} />
+            <IconButton
+              name="times"
+              size="md"
+              aria-label={`Remove ${children}`}
+              onClick={(e) => {
+                e.stopPropagation();
+                onRemove();
+              }}
+            />
+          </>
+        )}
+      </span>
+    );
+  }
+);
 
-const getValuePillStyles = (theme: GrafanaTheme2) => ({
+const getValuePillStyles = (theme: GrafanaTheme2, disabled?: boolean) => ({
   wrapper: css({
     display: 'inline-flex',
     gap: theme.spacing(0.5),
@@ -38,6 +45,7 @@ const getValuePillStyles = (theme: GrafanaTheme2) => ({
     color: theme.colors.text.primary,
     background: theme.colors.background.secondary,
     padding: theme.spacing(0.25),
+    border: disabled ? `1px solid ${theme.colors.border.weak}` : 'none',
     fontSize: theme.typography.bodySmall.fontSize,
     flexShrink: 0,
     minWidth: '50px',
diff --git a/packages/grafana-ui/src/components/Combobox/getMultiComboboxStyles.ts b/packages/grafana-ui/src/components/Combobox/getMultiComboboxStyles.ts
index 4f7551ddf2e..107a881cf5c 100644
--- a/packages/grafana-ui/src/components/Combobox/getMultiComboboxStyles.ts
+++ b/packages/grafana-ui/src/components/Combobox/getMultiComboboxStyles.ts
@@ -5,8 +5,13 @@ import { GrafanaTheme2 } from '@grafana/data';
 import { getFocusStyles } from '../../themes/mixins';
 import { getInputStyles } from '../Input/Input';
 
-export const getMultiComboboxStyles = (theme: GrafanaTheme2, isOpen: boolean) => {
-  const inputStyles = getInputStyles({ theme });
+export const getMultiComboboxStyles = (
+  theme: GrafanaTheme2,
+  isOpen: boolean,
+  invalid?: boolean,
+  disabled?: boolean
+) => {
+  const inputStyles = getInputStyles({ theme, invalid });
   const focusStyles = getFocusStyles(theme);
 
   return {
@@ -52,6 +57,7 @@ export const getMultiComboboxStyles = (theme: GrafanaTheme2, isOpen: boolean) =>
       alignItems: 'center',
       justifyContent: 'center',
       padding: theme.spacing(0, 1),
+      border: disabled ? `1px solid ${theme.colors.border.weak}` : 'none',
       borderRadius: theme.shape.radius.default,
       backgroundColor: theme.colors.background.secondary,
       cursor: 'pointer',
@@ -59,5 +65,7 @@ export const getMultiComboboxStyles = (theme: GrafanaTheme2, isOpen: boolean) =>
         backgroundColor: theme.colors.action.hover,
       },
     }),
+    suffix: inputStyles.suffix,
+    disabled: inputStyles.inputDisabled,
   };
 };
diff --git a/packages/grafana-ui/src/components/Combobox/useMeasureMulti.ts b/packages/grafana-ui/src/components/Combobox/useMeasureMulti.ts
index 83a5b0e2871..79a7722df4d 100644
--- a/packages/grafana-ui/src/components/Combobox/useMeasureMulti.ts
+++ b/packages/grafana-ui/src/components/Combobox/useMeasureMulti.ts
@@ -7,26 +7,31 @@ import { ComboboxOption } from './Combobox';
 
 const FONT_SIZE = 12;
 const EXTRA_PILL_SIZE = 50;
+const EXTRA_PILL_DISABLED_SIZE = 10;
 
 /**
  * Updates the number of shown items in the multi combobox based on the available width.
  */
 export function useMeasureMulti<T extends string | number>(
   selectedItems: Array<ComboboxOption<T>>,
-  width?: number | 'auto'
+  width?: number | 'auto',
+  disabled?: boolean
 ) {
   const [shownItems, setShownItems] = useState<number>(selectedItems.length);
   const [measureRef, { width: containerWidth }] = useMeasure<HTMLDivElement>();
+  const [counterMeasureRef, { width: counterWidth }] = useMeasure<HTMLDivElement>();
   const [suffixMeasureRef, { width: suffixWidth }] = useMeasure<HTMLDivElement>();
 
   const finalWidth = width && width !== 'auto' ? width : containerWidth;
 
   useEffect(() => {
-    const maxWidth = finalWidth - suffixWidth;
+    const maxWidth = finalWidth - counterWidth - suffixWidth;
     let currWidth = 0;
     for (let i = 0; i < selectedItems.length; i++) {
       // Measure text width and add size of padding, separator and close button
-      currWidth += measureText(selectedItems[i].label || '', FONT_SIZE).width + EXTRA_PILL_SIZE;
+      currWidth +=
+        measureText(selectedItems[i].label || '', FONT_SIZE).width +
+        (disabled ? EXTRA_PILL_DISABLED_SIZE : EXTRA_PILL_SIZE);
       if (currWidth > maxWidth) {
         // If there is no space for that item, show the current number of items,
         // but always show at least 1 item
@@ -38,7 +43,7 @@ export function useMeasureMulti<T extends string | number>(
         setShownItems(selectedItems.length);
       }
     }
-  }, [finalWidth, suffixWidth, selectedItems, setShownItems]);
+  }, [finalWidth, counterWidth, suffixWidth, selectedItems, setShownItems, disabled]);
 
-  return { measureRef, suffixMeasureRef, shownItems };
+  return { measureRef, counterMeasureRef, suffixMeasureRef, shownItems };
 }