diff --git a/packages/grafana-data/src/index.ts b/packages/grafana-data/src/index.ts
index 28cb92c47d3..55380d4a746 100644
--- a/packages/grafana-data/src/index.ts
+++ b/packages/grafana-data/src/index.ts
@@ -98,7 +98,7 @@ export {
 } from './text/string';
 export { type TextMatch, findHighlightChunksInText, findMatchesInText, parseFlags } from './text/text';
 export { type RenderMarkdownOptions, renderMarkdown, renderTextPanelMarkdown } from './text/markdown';
-export { textUtil } from './text/sanitize';
+export { textUtil, validatePath, PathValidationError } from './text/sanitize';
 
 // Events
 export { eventFactory } from './events/eventFactory';
diff --git a/packages/grafana-data/src/text/sanitize.test.ts b/packages/grafana-data/src/text/sanitize.test.ts
index 37d616055a7..218e4064046 100644
--- a/packages/grafana-data/src/text/sanitize.test.ts
+++ b/packages/grafana-data/src/text/sanitize.test.ts
@@ -1,4 +1,4 @@
-import { sanitizeTextPanelContent, sanitizeUrl, sanitize } from './sanitize';
+import { sanitizeTextPanelContent, sanitizeUrl, sanitize, validatePath, PathValidationError } from './sanitize';
 
 describe('sanitizeTextPanelContent', () => {
   it('should allow whitelisted styles in text panel', () => {
@@ -56,3 +56,97 @@ describe('sanitize', () => {
     expect(str).toBe('');
   });
 });
+
+describe('validatePath', () => {
+  describe('path traversal protection', () => {
+    it('should block simple path traversal attempts', () => {
+      expect(() => validatePath('/api/../admin')).toThrow(PathValidationError);
+      expect(() => validatePath('api/../admin')).toThrow(PathValidationError);
+      expect(() => validatePath('../admin')).toThrow(PathValidationError);
+    });
+
+    it('should block URL encoded path traversal attempts', () => {
+      expect(() => validatePath('/api/%2e%2e/admin')).toThrow(PathValidationError);
+      expect(() => validatePath('/api/%252e%252e/admin')).toThrow(PathValidationError);
+    });
+
+    it('should block double encoded traversal attempts', () => {
+      expect(() => validatePath('/api/%252e%252e/admin')).toThrow(PathValidationError);
+    });
+
+    it('should handle malformed URI encoding gracefully', () => {
+      expect(() => validatePath('/api/%/admin')).toThrow(PathValidationError);
+      expect(() => validatePath('/api/%2/admin')).toThrow(PathValidationError);
+    });
+  });
+
+  describe('safe paths', () => {
+    it('should preserve safe paths', () => {
+      expect(validatePath('/api/users/123')).toBe('/api/users/123');
+      expect(validatePath('/api/dashboard/save')).toBe('/api/dashboard/save');
+      expect(validatePath('api/config')).toBe('api/config');
+    });
+
+    it('should preserve paths with file extensions', () => {
+      expect(validatePath('/api/file.json')).toBe('/api/file.json');
+      expect(validatePath('/static/image.png')).toBe('/static/image.png');
+    });
+
+    it('should preserve paths with query parameters', () => {
+      expect(validatePath('/api/search?q=test')).toBe('/api/search?q=test');
+      expect(validatePath('/api/file.json?version=1.2.3&format=compact')).toBe(
+        '/api/file.json?version=1.2.3&format=compact'
+      );
+    });
+
+    it('should handle empty and root paths', () => {
+      expect(validatePath('')).toBe('');
+      expect(validatePath('/')).toBe('/');
+    });
+  });
+
+  describe('full URL handling', () => {
+    it('should preserve safe full URLs', () => {
+      const safeUrl = 'https://api.example.com/users/123';
+      expect(validatePath(safeUrl)).toBe(safeUrl);
+    });
+
+    it('should preserve URLs with query parameters and fragments', () => {
+      const urlWithQuery = 'https://api.example.com/search?q=test&limit=10#results';
+      expect(validatePath(urlWithQuery)).toBe(urlWithQuery);
+    });
+
+    it('should block traversal in URL paths while preserving query params', () => {
+      expect(() => validatePath('https://api.example.com/api/../admin?token=abc')).toThrow(PathValidationError);
+      expect(() => validatePath('http://localhost:3000/api/%2e%2e/secrets?param=value')).toThrow(PathValidationError);
+    });
+
+    it('should allow legitimate dots in URL paths with query params', () => {
+      const urlWithDots = 'https://cdn.example.com/files/document.v1.2.pdf?download=true';
+      expect(validatePath(urlWithDots)).toBe(urlWithDots);
+    });
+
+    it('should allow query parameters that contain dots', () => {
+      const urlWithDotsInQuery = 'https://api.example.com/search?version=1.2.3&file=../config';
+      expect(validatePath(urlWithDotsInQuery)).toBe(urlWithDotsInQuery);
+    });
+
+    it('should handle malformed URLs gracefully', () => {
+      expect(() => validatePath('not-a-url://../admin')).toThrow(PathValidationError);
+      expect(validatePath('://malformed')).toBe('://malformed'); // No traversal attempt, so it's allowed
+    });
+
+    it('should handle URLs with different protocols', () => {
+      expect(validatePath('ftp://files.example.com/safe/path')).toBe('ftp://files.example.com/safe/path');
+      expect(() => validatePath('ftp://files.example.com/../secrets')).toThrow(PathValidationError);
+    });
+
+    it('should handle URLs with backslashes', () => {
+      expect(() => validatePath('https://api.example.com/\\example.com')).toThrow(PathValidationError);
+    });
+
+    it('should handle URLs with backslashes and dots in the path', () => {
+      expect(() => validatePath('https://api.example.com/\\..\\/admin')).toThrow(PathValidationError);
+    });
+  });
+});
diff --git a/packages/grafana-data/src/text/sanitize.ts b/packages/grafana-data/src/text/sanitize.ts
index c2be3a917ee..8fed4311627 100644
--- a/packages/grafana-data/src/text/sanitize.ts
+++ b/packages/grafana-data/src/text/sanitize.ts
@@ -120,6 +120,54 @@ export function escapeHtml(str: string): string {
     .replace(/"/g, '"');
 }
 
+export class PathValidationError extends Error {
+  constructor(message = 'Invalid request path') {
+    super(message);
+    this.name = 'PathValidationError';
+    // Maintains proper stack trace for where error was thrown (only available on V8)
+    if (Error.captureStackTrace) {
+      Error.captureStackTrace(this, PathValidationError);
+    }
+  }
+}
+
+/**
+ * Validates a path or URL, protecting against path traversal attacks.
+ * Returns the original input if safe, or throw an error
+ */
+export function validatePath<OriginalPath extends string>(path: OriginalPath): OriginalPath {
+  try {
+    let originalDecoded: string = path; // down-cast to a string to indicate this can't be returned
+    while (true) {
+      const nextDecode = decodeURIComponent(originalDecoded);
+      if (nextDecode === originalDecoded) {
+        break; // String is fully decoded.
+      }
+      originalDecoded = nextDecode;
+    }
+
+    // Remove query params and fragments to check only the path portion
+    const cleaned = originalDecoded.split(/[\?&#]/)[0];
+    originalDecoded = cleaned;
+
+    // If the original string contains traversal attempts, block it
+    if (originalDecoded.includes('..') || originalDecoded.includes('/\\')) {
+      throw new PathValidationError();
+    }
+
+    return path;
+  } catch (err) {
+    // Rethrow the original InvalidPathError to preserve the stack trace
+    if (err instanceof PathValidationError) {
+      throw err;
+    }
+
+    // A decoding error can happen with malformed URIs (e.g., % not followed by hex).
+    // These are suspicious, so we treat them as traversal attempts.
+    throw new PathValidationError('Error validating request path');
+  }
+}
+
 export const textUtil = {
   escapeHtml,
   hasAnsiCodes,
diff --git a/packages/grafana-runtime/src/services/backendSrv.ts b/packages/grafana-runtime/src/services/backendSrv.ts
index 14352c6aabb..79447166773 100644
--- a/packages/grafana-runtime/src/services/backendSrv.ts
+++ b/packages/grafana-runtime/src/services/backendSrv.ts
@@ -85,6 +85,12 @@ export type BackendSrvRequest = {
    * @deprecated withCredentials is deprecated in favor of credentials
    */
   withCredentials?: boolean;
+
+  /**
+   * Set to true to validate the URL path to prevent path traversal attacks.
+   * Use this when constructing URLs from user input.
+   */
+  validatePath?: boolean;
 };
 
 /**
diff --git a/public/app/core/services/backend_srv.ts b/public/app/core/services/backend_srv.ts
index 57c6dc9d862..ac0d13d1051 100644
--- a/public/app/core/services/backend_srv.ts
+++ b/public/app/core/services/backend_srv.ts
@@ -147,7 +147,14 @@ export class BackendSrv implements BackendService {
   chunked(options: BackendSrvRequest): Observable<FetchResponse<Uint8Array | undefined>> {
     const requestId = options.requestId ?? `chunked-${this.chunkRequestId++}`;
     const controller = new AbortController();
-    const url = parseUrlFromOptions(options);
+
+    let url: string;
+    try {
+      url = parseUrlFromOptions(options);
+    } catch (error) {
+      return throwError(() => error);
+    }
+
     const init = parseInitFromOptions({
       ...options,
       requestId,
@@ -295,9 +302,15 @@ export class BackendSrv implements BackendService {
   }
 
   private getFromFetchStream<T>(options: BackendSrvRequest): Observable<FetchResponse<T>> {
-    const url = parseUrlFromOptions(options);
     const init = parseInitFromOptions(options);
 
+    let url: string;
+    try {
+      url = parseUrlFromOptions(options);
+    } catch (error) {
+      return throwError(() => error);
+    }
+
     return this.dependencies.fromFetch(url, init).pipe(
       mergeMap(async (response) => {
         const { status, statusText, ok, headers, url, type, redirected } = response;
diff --git a/public/app/core/specs/backend_srv.test.ts b/public/app/core/specs/backend_srv.test.ts
index ac96cfc2572..097788913d8 100644
--- a/public/app/core/specs/backend_srv.test.ts
+++ b/public/app/core/specs/backend_srv.test.ts
@@ -2,7 +2,7 @@ import { Observable, of, lastValueFrom } from 'rxjs';
 import { fromFetch } from 'rxjs/fetch';
 import { delay } from 'rxjs/operators';
 
-import { AppEvents, DataQueryErrorType, EventBusExtended } from '@grafana/data';
+import { AppEvents, DataQueryErrorType, EventBusExtended, PathValidationError } from '@grafana/data';
 import { BackendSrvRequest, FetchError, FetchResponse } from '@grafana/runtime';
 
 import { TokenRevokedModal } from '../../features/users/TokenRevokedModal';
@@ -745,4 +745,142 @@ describe('backendSrv', () => {
       });
     });
   });
+
+  describe('validatePath functionality', () => {
+    describe('when validatePath is enabled in options', () => {
+      it.each(['get', 'post', 'put', 'patch', 'delete'] as const)(
+        'should sanitize malicious paths in $method requests',
+        async (method) => {
+          const { backendSrv } = getTestContext();
+          const maliciousUrl = '/api/users/%2e%2e/admin';
+
+          const promise =
+            method === 'get'
+              ? backendSrv[method](maliciousUrl, undefined, undefined, { validatePath: true })
+              : backendSrv[method](maliciousUrl, undefined, { validatePath: true });
+
+          await expect(promise).rejects.toThrow(PathValidationError);
+          await expect(promise).rejects.toThrow('Invalid request path');
+        }
+      );
+
+      it('should preserve safe paths when sanitizing', async () => {
+        const { backendSrv } = getTestContext();
+        const safeUrl = '/api/users/123';
+
+        const promise = backendSrv.get(safeUrl, undefined, undefined, { validatePath: true });
+
+        await expect(promise).resolves.toBeDefined();
+      });
+
+      it('should sanitise paths when calling .request', async () => {
+        const { backendSrv } = getTestContext();
+        const maliciousUrl = '/api/users/%2e%2e/admin';
+
+        const promise = backendSrv.request({ url: maliciousUrl, method: 'GET', validatePath: true });
+
+        await expect(promise).rejects.toThrow(PathValidationError);
+      });
+
+      it('should sanitise paths when calling .fetch', (done) => {
+        const { backendSrv } = getTestContext();
+        const maliciousUrl = '/api/users/%2e%2e/admin';
+
+        const observable = backendSrv.fetch({ url: maliciousUrl, method: 'GET', validatePath: true });
+
+        observable.subscribe({
+          next: () => {
+            throw new Error('Should not succeed');
+          },
+          error: (err) => {
+            expect(err).toBeInstanceOf(PathValidationError);
+            expect(err.message).toBe('Invalid request path');
+            done();
+          },
+        });
+      });
+    });
+
+    describe('when validatePath is disabled or not provided', () => {
+      it('should not sanitize paths when validatePath is false', async () => {
+        const { backendSrv } = getTestContext();
+        const maliciousUrl = '/api/../admin/secrets';
+
+        const promise = backendSrv.get(maliciousUrl, undefined, undefined, { validatePath: false });
+
+        await expect(promise).resolves.toBeDefined();
+      });
+
+      it('should not sanitize paths when validatePath is not provided', async () => {
+        const { backendSrv } = getTestContext();
+        const maliciousUrl = '/api/../admin/secrets';
+
+        const promise = backendSrv.get(maliciousUrl);
+
+        await expect(promise).resolves.toBeDefined();
+      });
+
+      it('should preserve paths when only other options are provided', async () => {
+        const { backendSrv } = getTestContext();
+        const maliciousUrl = '/api/../admin/secrets';
+
+        const promise = backendSrv.delete(maliciousUrl, undefined, { showErrorAlert: false });
+
+        await expect(promise).resolves.toBeDefined();
+      });
+    });
+
+    describe('with complex validatePath scenarios', () => {
+      it('should handle URL encoded traversal attacks', async () => {
+        const { backendSrv } = getTestContext();
+        const encodedUrl = '/api/%252e%252e/admin';
+
+        const promise = backendSrv.get(encodedUrl, undefined, undefined, { validatePath: true });
+
+        await expect(promise).rejects.toThrow(PathValidationError);
+      });
+
+      it('should preserve paths with legitimate dots and query parameters', async () => {
+        const { backendSrv, parseRequestOptionsMock } = getTestContext();
+        const safeUrl = '/api/file.json?version=1.2.3&format=compact';
+
+        const promise = backendSrv.get(safeUrl, undefined, undefined, { validatePath: true });
+
+        await expect(promise).resolves.toBeDefined();
+        expect(parseRequestOptionsMock).toHaveBeenCalledWith(
+          expect.objectContaining({
+            url: '/api/file.json?version=1.2.3&format=compact', // legitimate dots and query params should be preserved
+            method: 'GET',
+            validatePath: true,
+          })
+        );
+      });
+
+      it('should work with other options combined', async () => {
+        const { backendSrv, parseRequestOptionsMock } = getTestContext();
+        const safeUrl = '/api/dashboard/save';
+
+        const promise = backendSrv.post(
+          safeUrl,
+          { dashboard: 'data' },
+          {
+            validatePath: true,
+            showErrorAlert: false,
+            showSuccessAlert: true,
+          }
+        );
+
+        await expect(promise).resolves.toBeDefined();
+        expect(parseRequestOptionsMock).toHaveBeenCalledWith(
+          expect.objectContaining({
+            url: '/api/dashboard/save',
+            method: 'POST',
+            validatePath: true,
+            showErrorAlert: false,
+            showSuccessAlert: true,
+          })
+        );
+      });
+    });
+  });
 });
diff --git a/public/app/core/utils/fetch.test.ts b/public/app/core/utils/fetch.test.ts
index 4c05a50497c..cd613132413 100644
--- a/public/app/core/utils/fetch.test.ts
+++ b/public/app/core/utils/fetch.test.ts
@@ -1,3 +1,5 @@
+import { PathValidationError } from '@grafana/data';
+
 import {
   isContentTypeJson,
   parseBody,
@@ -29,6 +31,18 @@ describe('parseUrlFromOptions', () => {
       expect(parseUrlFromOptions({ params, url })).toEqual(expected);
     }
   );
+
+  it('should validate the path if validatePath is true', () => {
+    expect(() => parseUrlFromOptions({ url: '/api/users/%2e%2e/admin', validatePath: true })).toThrow(
+      PathValidationError
+    );
+  });
+
+  it('should not validate the path if validatePath is false', () => {
+    expect(parseUrlFromOptions({ url: '/api/users/%2e%2e/admin', validatePath: false })).toEqual(
+      '/api/users/%2e%2e/admin'
+    );
+  });
 });
 
 describe('parseInitFromOptions', () => {
diff --git a/public/app/core/utils/fetch.ts b/public/app/core/utils/fetch.ts
index 237c5d0eb13..a456f35e066 100644
--- a/public/app/core/utils/fetch.ts
+++ b/public/app/core/utils/fetch.ts
@@ -1,6 +1,6 @@
 import { omitBy } from 'lodash';
 
-import { deprecationWarning } from '@grafana/data';
+import { deprecationWarning, validatePath } from '@grafana/data';
 import { BackendSrvRequest } from '@grafana/runtime';
 
 export const parseInitFromOptions = (options: BackendSrvRequest): RequestInit => {
@@ -164,10 +164,19 @@ function serializeParams(data: Record<string, any>): string {
     .join('&');
 }
 
+/**
+ * Formats and validates the URL.
+ * If options.validatePath is true, this will throw an exception if the URL fails validation.
+ */
 export const parseUrlFromOptions = (options: BackendSrvRequest): string => {
   const cleanParams = omitBy(options.params, (v) => v === undefined || (v && v.length === 0));
   const serializedParams = serializeParams(cleanParams);
-  return options.params && serializedParams.length ? `${options.url}?${serializedParams}` : options.url;
+
+  const url = options.validatePath //
+    ? validatePath(options.url)
+    : options.url;
+
+  return options.params && serializedParams.length ? `${url}?${serializedParams}` : url;
 };
 
 export const parseCredentials = (options: BackendSrvRequest): RequestCredentials => {
diff --git a/public/app/features/dashboard/api/legacy.ts b/public/app/features/dashboard/api/legacy.ts
index 8833958ec5f..5ce46cdf442 100644
--- a/public/app/features/dashboard/api/legacy.ts
+++ b/public/app/features/dashboard/api/legacy.ts
@@ -29,11 +29,14 @@ export class LegacyDashboardAPI implements DashboardAPI<DashboardDTO, Dashboard>
   deleteDashboard(uid: string, showSuccessAlert: boolean): Promise<DeleteDashboardResponse> {
     return getBackendSrv().delete<DeleteDashboardResponse>(`/api/dashboards/uid/${uid}`, undefined, {
       showSuccessAlert,
+      validatePath: true,
     });
   }
 
   async getDashboardDTO(uid: string, params?: UrlQueryMap) {
-    const result = await getBackendSrv().get<DashboardDTO>(`/api/dashboards/uid/${uid}`, params);
+    const result = await getBackendSrv().get<DashboardDTO>(`/api/dashboards/uid/${uid}`, params, undefined, {
+      validatePath: true,
+    });
 
     if (result.meta.isFolder) {
       appEvents.emit(AppEvents.alertError, ['Dashboard not found']);
diff --git a/public/app/features/dashboard/services/DashboardLoaderSrv.ts b/public/app/features/dashboard/services/DashboardLoaderSrv.ts
index c3629145e15..22bb842a761 100644
--- a/public/app/features/dashboard/services/DashboardLoaderSrv.ts
+++ b/public/app/features/dashboard/services/DashboardLoaderSrv.ts
@@ -43,7 +43,7 @@ abstract class DashboardLoaderSrvBase<T> implements DashboardLoaderSrvLike<T> {
     const url = 'public/dashboards/' + file.replace(/\.(?!js)/, '/') + '?' + new Date().getTime();
 
     return getBackendSrv()
-      .get(url)
+      .get(url, undefined, undefined, { validatePath: true })
       .then(this.executeScript.bind(this))
       .then(
         (result: any) => {
diff --git a/public/app/features/datasources/api.ts b/public/app/features/datasources/api.ts
index 1cec20fe125..e1ff17ff598 100644
--- a/public/app/features/datasources/api.ts
+++ b/public/app/features/datasources/api.ts
@@ -74,6 +74,7 @@ export const updateDataSource = (dataSource: DataSourceSettings) => {
   return getBackendSrv().put(`/api/datasources/uid/${dataSource.uid}`, dataSource, {
     showErrorAlert: false,
     showSuccessAlert: false,
+    validatePath: true,
   });
 };
 
diff --git a/public/app/features/library-panels/state/api.ts b/public/app/features/library-panels/state/api.ts
index 5466f0e79f6..6ae546af666 100644
--- a/public/app/features/library-panels/state/api.ts
+++ b/public/app/features/library-panels/state/api.ts
@@ -83,7 +83,14 @@ export async function getLibraryPanel(uid: string, isHandled = false): Promise<L
 }
 
 export async function getLibraryPanelByName(name: string): Promise<LibraryElementDTO[]> {
-  const { result } = await getBackendSrv().get<{ result: LibraryElementDTO[] }>(`/api/library-elements/name/${name}`);
+  const { result } = await getBackendSrv().get<{ result: LibraryElementDTO[] }>(
+    `/api/library-elements/name/${name}`,
+    undefined,
+    undefined,
+    {
+      validatePath: true,
+    }
+  );
   return result;
 }
 
diff --git a/public/app/features/plugins/pluginSettings.test.ts b/public/app/features/plugins/pluginSettings.test.ts
index b9dc92bf1da..02c16af039b 100644
--- a/public/app/features/plugins/pluginSettings.test.ts
+++ b/public/app/features/plugins/pluginSettings.test.ts
@@ -29,7 +29,9 @@ describe('PluginSettings', () => {
     // assert
     expect(response).toEqual(testPluginResponse);
     expect(getRequestSpy).toHaveBeenCalledTimes(1);
-    expect(getRequestSpy).toHaveBeenCalledWith('/api/plugins/test/settings', undefined, undefined, undefined);
+    expect(getRequestSpy).toHaveBeenCalledWith('/api/plugins/test/settings', undefined, undefined, {
+      validatePath: true,
+    });
   });
 
   it('should fetch settings from cache when it has a hit', async () => {
diff --git a/public/app/features/plugins/pluginSettings.ts b/public/app/features/plugins/pluginSettings.ts
index 135cdbb9e97..1865df5b914 100644
--- a/public/app/features/plugins/pluginSettings.ts
+++ b/public/app/features/plugins/pluginSettings.ts
@@ -13,7 +13,7 @@ export function getPluginSettings(pluginId: string, options?: Partial<BackendSrv
     return Promise.resolve(v);
   }
   return getBackendSrv()
-    .get(`/api/plugins/${pluginId}/settings`, undefined, undefined, options)
+    .get(`/api/plugins/${pluginId}/settings`, undefined, undefined, { ...options, validatePath: true })
     .then((settings) => {
       pluginInfoCache[pluginId] = settings;
       return settings;