diff --git a/docs/sources/setup-grafana/configure-grafana/feature-toggles/index.md b/docs/sources/setup-grafana/configure-grafana/feature-toggles/index.md
index f40ad6a1766..7ceb0dc3460 100644
--- a/docs/sources/setup-grafana/configure-grafana/feature-toggles/index.md
+++ b/docs/sources/setup-grafana/configure-grafana/feature-toggles/index.md
@@ -226,6 +226,7 @@ Experimental features might be changed or removed without prior notice.
 | `datasourceConnectionsTab`                  | Shows defined connections for a data source in the plugins detail page                                                                                                                                                                                                            |
 | `newLogsPanel`                              | Enables the new logs panel in Explore                                                                                                                                                                                                                                             |
 | `pluginsCDNSyncLoader`                      | Load plugins from CDN synchronously                                                                                                                                                                                                                                               |
+| `assetSriChecks`                            | Enables SRI checks for Grafana JavaScript assets                                                                                                                                                                                                                                  |
 
 ## Development feature toggles
 
diff --git a/package.json b/package.json
index 1c9393c4bd9..3708b2b49ac 100644
--- a/package.json
+++ b/package.json
@@ -248,6 +248,7 @@
     "webpack-livereload-plugin": "3.0.2",
     "webpack-manifest-plugin": "5.0.0",
     "webpack-merge": "6.0.1",
+    "webpack-subresource-integrity": "^5.2.0-rc.1",
     "webpackbar": "^7.0.0",
     "yaml": "^2.0.0",
     "yargs": "^17.5.1"
diff --git a/packages/grafana-data/src/types/featureToggles.gen.ts b/packages/grafana-data/src/types/featureToggles.gen.ts
index 87c5ff7c0d1..7e3ac0d6dba 100644
--- a/packages/grafana-data/src/types/featureToggles.gen.ts
+++ b/packages/grafana-data/src/types/featureToggles.gen.ts
@@ -254,4 +254,5 @@ export interface FeatureToggles {
   alertingRuleVersionHistoryRestore?: boolean;
   newShareReportDrawer?: boolean;
   rendererDisableAppPluginsPreload?: boolean;
+  assetSriChecks?: boolean;
 }
diff --git a/pkg/services/featuremgmt/codeowners.go b/pkg/services/featuremgmt/codeowners.go
index 13520e2a02b..a201b5e4b23 100644
--- a/pkg/services/featuremgmt/codeowners.go
+++ b/pkg/services/featuremgmt/codeowners.go
@@ -13,6 +13,7 @@ const (
 	grafanaBackendServicesSquad                 codeowner = "@grafana/grafana-backend-services-squad"
 	grafanaSearchAndStorageSquad                codeowner = "@grafana/search-and-storage"
 	grafanaPluginsPlatformSquad                 codeowner = "@grafana/plugins-platform-backend"
+	grafanaFrontendOpsWG                        codeowner = "@grafana/frontend-ops"
 	grafanaAsCodeSquad                          codeowner = "@grafana/grafana-as-code"
 	identityAccessTeam                          codeowner = "@grafana/identity-access-team"
 	grafanaObservabilityLogsSquad               codeowner = "@grafana/observability-logs"
diff --git a/pkg/services/featuremgmt/registry.go b/pkg/services/featuremgmt/registry.go
index f3b1da31b5c..27da9533003 100644
--- a/pkg/services/featuremgmt/registry.go
+++ b/pkg/services/featuremgmt/registry.go
@@ -1775,6 +1775,13 @@ var (
 			HideFromDocs:      true,
 			FrontendOnly:      true,
 		},
+		{
+			Name:         "assetSriChecks",
+			Description:  "Enables SRI checks for Grafana JavaScript assets",
+			Stage:        FeatureStageExperimental,
+			Owner:        grafanaFrontendOpsWG,
+			FrontendOnly: true,
+		},
 	}
 )
 
diff --git a/pkg/services/featuremgmt/toggles_gen.csv b/pkg/services/featuremgmt/toggles_gen.csv
index fc0b0c8dfb7..ace09d69f56 100644
--- a/pkg/services/featuremgmt/toggles_gen.csv
+++ b/pkg/services/featuremgmt/toggles_gen.csv
@@ -235,3 +235,4 @@ alertingJiraIntegration,experimental,@grafana/alerting-squad,false,false,true
 alertingRuleVersionHistoryRestore,GA,@grafana/alerting-squad,false,false,true
 newShareReportDrawer,experimental,@grafana/sharing-squad,false,false,false
 rendererDisableAppPluginsPreload,experimental,@grafana/sharing-squad,false,false,true
+assetSriChecks,experimental,@grafana/frontend-ops,false,false,true
diff --git a/pkg/services/featuremgmt/toggles_gen.go b/pkg/services/featuremgmt/toggles_gen.go
index 56c3a7d53da..d651c7290f6 100644
--- a/pkg/services/featuremgmt/toggles_gen.go
+++ b/pkg/services/featuremgmt/toggles_gen.go
@@ -950,4 +950,8 @@ const (
 	// FlagRendererDisableAppPluginsPreload
 	// Disable pre-loading app plugins when the request is coming from the renderer
 	FlagRendererDisableAppPluginsPreload = "rendererDisableAppPluginsPreload"
+
+	// FlagAssetSriChecks
+	// Enables SRI checks for Grafana JavaScript assets
+	FlagAssetSriChecks = "assetSriChecks"
 )
diff --git a/pkg/services/featuremgmt/toggles_gen.json b/pkg/services/featuremgmt/toggles_gen.json
index 3f5045123d9..b093cb5dd21 100644
--- a/pkg/services/featuremgmt/toggles_gen.json
+++ b/pkg/services/featuremgmt/toggles_gen.json
@@ -598,6 +598,22 @@
         "codeowner": "@grafana/grafana-frontend-platform"
       }
     },
+    {
+      "metadata": {
+        "name": "assetSriChecks",
+        "resourceVersion": "1739984409734",
+        "creationTimestamp": "2025-02-19T15:56:59Z",
+        "annotations": {
+          "grafana.app/updatedTimestamp": "2025-02-19 17:00:09.734088 +0000 UTC"
+        }
+      },
+      "spec": {
+        "description": "Enables SRI checks for Grafana JavaScript assets",
+        "stage": "experimental",
+        "codeowner": "@grafana/frontend-ops",
+        "frontend": true
+      }
+    },
     {
       "metadata": {
         "name": "authAPIAccessTokenAuth",
diff --git a/public/views/index.html b/public/views/index.html
index cd539b05c9e..d7c54f4967b 100644
--- a/public/views/index.html
+++ b/public/views/index.html
@@ -355,13 +355,26 @@
     <!-- End Google Tag Manager -->
     [[end]]
 
-    [[range $asset := .Assets.JSFiles]]
-      <script
-      nonce="[[$.Nonce]]"
-      src="[[$asset.FilePath]]"
-      type="text/javascript"
-      defer
-    ></script>
+    [[if .Settings.FeatureToggles.assetSriChecks ]]
+      [[range $asset := .Assets.JSFiles]]
+        <script
+        nonce="[[$.Nonce]]"
+        src="[[$asset.FilePath]]"
+        integrity="[[$asset.Integrity]]"
+        crossorigin="anonymous"
+        type="text/javascript"
+        defer
+      ></script>
+      [[end]]
+    [[else]]
+      [[range $asset := .Assets.JSFiles]]
+        <script
+        nonce="[[$.Nonce]]"
+        src="[[$asset.FilePath]]"
+        type="text/javascript"
+        defer
+      ></script>
+      [[end]]
     [[end]]
 
     <script nonce="[[.Nonce]]">
diff --git a/scripts/webpack/plugins/FeatureFlaggedSriPlugin.js b/scripts/webpack/plugins/FeatureFlaggedSriPlugin.js
new file mode 100644
index 00000000000..08b85af67a8
--- /dev/null
+++ b/scripts/webpack/plugins/FeatureFlaggedSriPlugin.js
@@ -0,0 +1,66 @@
+// @ts-check
+const webpack = require('webpack');
+
+/** @typedef {import('webpack/lib/Compiler.js')} Compiler */
+
+const PLUGIN_NAME = 'FeatureFlaggedSRIPlugin';
+const FEATURE_TOGGLE_WRAP = [
+  'if (window.grafanaBootData && window.grafanaBootData.settings && window.grafanaBootData.settings.featureToggles && window.grafanaBootData.settings.featureToggles.assetSriChecks) {',
+  '}',
+];
+
+/**
+ * Webpack plugin that wraps Webpack runtime integrity checks in a feature flag
+ * This allows us to disable SRI checks in both the initial chunks but also in the
+ * dynamically loaded chunks.
+ */
+class FeatureFlaggedSRIPlugin {
+  /**
+   * @param {Compiler} compiler The webpack compiler instance
+   */
+  apply(compiler) {
+    compiler.hooks.afterPlugins.tap(PLUGIN_NAME, (compiler) => {
+      const logger = compiler.getInfrastructureLogger(PLUGIN_NAME);
+      compiler.hooks.thisCompilation.tap(
+        {
+          name: PLUGIN_NAME,
+        },
+        (compilation) => {
+          const { mainTemplate } = compilation;
+          mainTemplate.hooks.jsonpScript.tap(
+            PLUGIN_NAME,
+            /**
+             * @param {string} source
+             */
+            (source) => {
+              if (source.includes('script.integrity =')) {
+                logger.log('FeatureFlaggedSRIPlugin: Wrapping SRI checks in feature flag');
+                return createFeatureFlaggedSRITemplate(source);
+              }
+              return source;
+            }
+          );
+        }
+      );
+    });
+  }
+}
+
+/**
+ * Creates a template string wrapping the integrity and crossorigin attributes in a feature flag
+ * @param {string} source The original webpack template source
+ * @returns {string} The modified template source
+ */
+function createFeatureFlaggedSRITemplate(source) {
+  const lines = source.split('\n');
+  const integrityAttributeLineNumber = lines.findIndex((line) => line.includes('script.integrity ='));
+  const [prefix, suffix] = FEATURE_TOGGLE_WRAP;
+  return webpack.Template.asString([
+    ...lines.slice(0, integrityAttributeLineNumber),
+    prefix,
+    webpack.Template.indent(lines.slice(integrityAttributeLineNumber)),
+    suffix,
+  ]);
+}
+
+module.exports = FeatureFlaggedSRIPlugin;
diff --git a/scripts/webpack/webpack.dev.js b/scripts/webpack/webpack.dev.js
index 4d5e8349533..32caaa5fb9e 100644
--- a/scripts/webpack/webpack.dev.js
+++ b/scripts/webpack/webpack.dev.js
@@ -149,6 +149,7 @@ module.exports = (env = {}) => {
       new WebpackAssetsManifest({
         entrypoints: true,
         integrity: true,
+        integrityHashes: ['sha384', 'sha512'],
         publicPath: true,
       }),
       new WebpackBar({
diff --git a/scripts/webpack/webpack.prod.js b/scripts/webpack/webpack.prod.js
index 2edb26d8be9..c014f8b54d9 100644
--- a/scripts/webpack/webpack.prod.js
+++ b/scripts/webpack/webpack.prod.js
@@ -10,8 +10,10 @@ const { EnvironmentPlugin } = require('webpack');
 const WebpackAssetsManifest = require('webpack-assets-manifest');
 const { WebpackManifestPlugin } = require('webpack-manifest-plugin');
 const { merge } = require('webpack-merge');
+const { SubresourceIntegrityPlugin } = require('webpack-subresource-integrity');
 
 const getEnvConfig = require('./env-util.js');
+const FeatureFlaggedSRIPlugin = require('./plugins/FeatureFlaggedSriPlugin');
 const common = require('./webpack.common.js');
 const esbuildTargets = resolveToEsbuildTarget(browserslist(), { printUnknownTargets: false });
 
@@ -51,6 +53,9 @@ module.exports = (env = {}) =>
         }),
       ],
     },
+    output: {
+      crossOriginLoading: 'anonymous',
+    },
     optimization: {
       nodeEnv: 'production',
       minimize: parseInt(env.noMinify, 10) !== 1,
@@ -70,6 +75,8 @@ module.exports = (env = {}) =>
       new MiniCssExtractPlugin({
         filename: 'grafana.[name].[contenthash].css',
       }),
+      new SubresourceIntegrityPlugin(),
+      new FeatureFlaggedSRIPlugin(),
       /**
        * I know we have two manifest plugins here.
        * WebpackManifestPlugin was only used in prod before and does not support integrity hashes
@@ -77,6 +84,7 @@ module.exports = (env = {}) =>
       new WebpackAssetsManifest({
         entrypoints: true,
         integrity: true,
+        integrityHashes: ['sha384', 'sha512'],
         publicPath: true,
       }),
       new WebpackManifestPlugin({
diff --git a/yarn.lock b/yarn.lock
index dce63788f1d..1997ec990e2 100644
--- a/yarn.lock
+++ b/yarn.lock
@@ -18449,6 +18449,7 @@ __metadata:
     webpack-livereload-plugin: "npm:3.0.2"
     webpack-manifest-plugin: "npm:5.0.0"
     webpack-merge: "npm:6.0.1"
+    webpack-subresource-integrity: "npm:^5.2.0-rc.1"
     webpackbar: "npm:^7.0.0"
     whatwg-fetch: "npm:3.6.20"
     yaml: "npm:^2.0.0"
@@ -31911,6 +31912,19 @@ __metadata:
   languageName: node
   linkType: hard
 
+"webpack-subresource-integrity@npm:^5.2.0-rc.1":
+  version: 5.2.0-rc.1
+  resolution: "webpack-subresource-integrity@npm:5.2.0-rc.1"
+  peerDependencies:
+    html-webpack-plugin: ">= 5.0.0-beta.1 < 6"
+    webpack: ^5.12.0
+  peerDependenciesMeta:
+    html-webpack-plugin:
+      optional: true
+  checksum: 10/a63e4e999812a753c70070457e6a2fb7e7ef1a05d8525a89796024fc56f26a0e56bd3e8f2b25e61f0ae969d627770a1fe326bebb58c296577d40c6a12aa4be37
+  languageName: node
+  linkType: hard
+
 "webpack-virtual-modules@npm:^0.5.0":
   version: 0.5.0
   resolution: "webpack-virtual-modules@npm:0.5.0"