diff --git a/public/app/features/dashboard-scene/edit-pane/EditPaneHeader.tsx b/public/app/features/dashboard-scene/edit-pane/EditPaneHeader.tsx
index 9605d479df9..e7aa01f9ede 100644
--- a/public/app/features/dashboard-scene/edit-pane/EditPaneHeader.tsx
+++ b/public/app/features/dashboard-scene/edit-pane/EditPaneHeader.tsx
@@ -1,7 +1,7 @@
 import { css } from '@emotion/css';
 
 import { GrafanaTheme2 } from '@grafana/data';
-import { Button, Menu, Stack, Text, useStyles2, ConfirmButton, Dropdown, Icon, IconButton } from '@grafana/ui';
+import { Button, Menu, Stack, Text, useStyles2, Dropdown, Icon, IconButton } from '@grafana/ui';
 import { t } from 'app/core/internationalization';
 
 import { EditableDashboardElement } from '../scene/types/EditableDashboardElement';
@@ -20,6 +20,7 @@ export function EditPaneHeader({ element, editPane }: EditPaneHeaderProps) {
   const onCopy = element.onCopy?.bind(element);
   const onDuplicate = element.onDuplicate?.bind(element);
   const onDelete = element.onDelete?.bind(element);
+  const onConfirmDelete = element.onConfirmDelete?.bind(element);
   // temporary simple solution, should select parent element
   const onGoBack = () => editPane.clearSelection();
   const canGoBack = editPane.state.selection;
@@ -40,7 +41,7 @@ export function EditPaneHeader({ element, editPane }: EditPaneHeaderProps) {
       </Stack>
       <Stack direction="row" gap={1}>
         {element.renderActions && element.renderActions()}
-        {(onCopy || onDelete) && (
+        {(onCopy || onDuplicate) && (
           <Dropdown
             overlay={
               <Menu>
@@ -69,22 +70,15 @@ export function EditPaneHeader({ element, editPane }: EditPaneHeaderProps) {
           </Dropdown>
         )}
 
-        {onDelete && (
-          <ConfirmButton
-            onConfirm={onDelete}
-            confirmText="Confirm"
-            confirmVariant="destructive"
+        {(onDelete || onConfirmDelete) && (
+          <Button
+            onClick={onConfirmDelete || onDelete}
             size="sm"
-            closeOnConfirm={true}
-          >
-            <Button
-              size="sm"
-              variant="destructive"
-              fill="outline"
-              icon="trash-alt"
-              tooltip={t('dashboard.layout.common.delete', 'Delete')}
-            />
-          </ConfirmButton>
+            variant="destructive"
+            fill="outline"
+            icon="trash-alt"
+            tooltip={t('dashboard.layout.common.delete', 'Delete')}
+          />
         )}
       </Stack>
     </div>
diff --git a/public/app/features/dashboard-scene/edit-pane/MultiSelectedObjectsEditableElement.tsx b/public/app/features/dashboard-scene/edit-pane/MultiSelectedObjectsEditableElement.tsx
index 25bcdd807c9..860e7be2aaa 100644
--- a/public/app/features/dashboard-scene/edit-pane/MultiSelectedObjectsEditableElement.tsx
+++ b/public/app/features/dashboard-scene/edit-pane/MultiSelectedObjectsEditableElement.tsx
@@ -1,5 +1,7 @@
+import { appEvents } from 'app/core/core';
 import { t } from 'app/core/internationalization';
 import { OptionsPaneCategoryDescriptor } from 'app/features/dashboard/components/PanelEditor/OptionsPaneCategoryDescriptor';
+import { ShowConfirmModalEvent } from 'app/types/events';
 
 import { BulkActionElement } from '../scene/types/BulkActionElement';
 import { EditableDashboardElement, EditableDashboardElementInfo } from '../scene/types/EditableDashboardElement';
@@ -17,6 +19,19 @@ export class MultiSelectedObjectsEditableElement implements EditableDashboardEle
     return { typeName: t('dashboard.edit-pane.elements.objects', 'Objects'), icon: 'folder', instanceName: '' };
   }
 
+  public onConfirmDelete() {
+    appEvents.publish(
+      new ShowConfirmModalEvent({
+        title: t('dashboard.edit-pane.elements.multiple-elements', 'Multiple elements'),
+        text: t(
+          'dashboard.edit-pane.elements.multiple-elements-delete-text',
+          'Are you sure you want to delete these elements?'
+        ),
+        onConfirm: () => this.onDelete(),
+      })
+    );
+  }
+
   public onDelete() {
     this._elements.forEach((item) => item.onDelete());
   }
diff --git a/public/app/features/dashboard-scene/edit-pane/MultiSelectedVizPanelsEditableElement.tsx b/public/app/features/dashboard-scene/edit-pane/MultiSelectedVizPanelsEditableElement.tsx
index cbdd794d3bd..32449565bac 100644
--- a/public/app/features/dashboard-scene/edit-pane/MultiSelectedVizPanelsEditableElement.tsx
+++ b/public/app/features/dashboard-scene/edit-pane/MultiSelectedVizPanelsEditableElement.tsx
@@ -1,7 +1,9 @@
 import { v4 as uuidv4 } from 'uuid';
 
+import { appEvents } from 'app/core/core';
 import { t } from 'app/core/internationalization';
 import { OptionsPaneCategoryDescriptor } from 'app/features/dashboard/components/PanelEditor/OptionsPaneCategoryDescriptor';
+import { ShowConfirmModalEvent } from 'app/types/events';
 
 import { EditableDashboardElement, EditableDashboardElementInfo } from '../scene/types/EditableDashboardElement';
 
@@ -28,6 +30,19 @@ export class MultiSelectedVizPanelsEditableElement implements EditableDashboardE
     return [header];
   }
 
+  public onConfirmDelete() {
+    appEvents.publish(
+      new ShowConfirmModalEvent({
+        title: t('dashboard.edit-pane.elements.multiple-panels', 'Multiple panels'),
+        text: t(
+          'dashboard.edit-pane.elements.multiple-panels-delete-text',
+          'Are you sure you want to delete these panels? All queries will be removed.'
+        ),
+        onConfirm: () => this.onDelete(),
+      })
+    );
+  }
+
   public onDelete() {
     this._panels.forEach((panel) => {
       panel.onDelete();
diff --git a/public/app/features/dashboard-scene/edit-pane/VizPanelEditableElement.tsx b/public/app/features/dashboard-scene/edit-pane/VizPanelEditableElement.tsx
index b6a40e9dadf..a488e832da2 100644
--- a/public/app/features/dashboard-scene/edit-pane/VizPanelEditableElement.tsx
+++ b/public/app/features/dashboard-scene/edit-pane/VizPanelEditableElement.tsx
@@ -3,9 +3,11 @@ import { useMemo } from 'react';
 import { locationService } from '@grafana/runtime';
 import { sceneGraph, VizPanel } from '@grafana/scenes';
 import { Stack, Button } from '@grafana/ui';
+import { appEvents } from 'app/core/core';
 import { t, Trans } from 'app/core/internationalization';
 import { OptionsPaneCategoryDescriptor } from 'app/features/dashboard/components/PanelEditor/OptionsPaneCategoryDescriptor';
 import { OptionsPaneItemDescriptor } from 'app/features/dashboard/components/PanelEditor/OptionsPaneItemDescriptor';
+import { ShowConfirmModalEvent } from 'app/types/events';
 
 import {
   PanelBackgroundSwitch,
@@ -84,6 +86,22 @@ export class VizPanelEditableElement implements EditableDashboardElement, BulkAc
     layout.removePanel?.(this.panel);
   }
 
+  public onConfirmDelete() {
+    appEvents.publish(
+      new ShowConfirmModalEvent({
+        title: t('dashboard.viz-panel.delete-panel-title', 'Delete panel?'),
+        text: t(
+          'dashboard.viz-panel.delete-panel-text',
+          'Deleting this panel will also remove all queries. Are you sure you want to continue?'
+        ),
+        yesText: t('dashboard.viz-panel.delete-panel-yes', 'Delete'),
+        onConfirm: () => {
+          this.onDelete();
+        },
+      })
+    );
+  }
+
   public onDuplicate() {
     const layout = dashboardSceneGraph.getLayoutManagerFor(this.panel);
     layout.duplicatePanel?.(this.panel);
diff --git a/public/app/features/dashboard-scene/scene/layout-rows/RowItem.tsx b/public/app/features/dashboard-scene/scene/layout-rows/RowItem.tsx
index 135ebb139c1..9ca3eb2061b 100644
--- a/public/app/features/dashboard-scene/scene/layout-rows/RowItem.tsx
+++ b/public/app/features/dashboard-scene/scene/layout-rows/RowItem.tsx
@@ -9,11 +9,13 @@ import {
   VizPanel,
 } from '@grafana/scenes';
 import { RowsLayoutRowKind } from '@grafana/schema/dist/esm/schema/dashboard/v2alpha1/types.spec.gen';
+import appEvents from 'app/core/app_events';
 import { LS_ROW_COPY_KEY } from 'app/core/constants';
 import { t } from 'app/core/internationalization';
 import store from 'app/core/store';
 import kbn from 'app/core/utils/kbn';
 import { OptionsPaneCategoryDescriptor } from 'app/features/dashboard/components/PanelEditor/OptionsPaneCategoryDescriptor';
+import { ShowConfirmModalEvent } from 'app/types/events';
 
 import { ConditionalRendering } from '../../conditional-rendering/ConditionalRendering';
 import { serializeRow } from '../../serialization/layoutSerializers/RowsLayoutSerializer';
@@ -110,6 +112,32 @@ export class RowItem
     this.getParentLayout().removeRow(this);
   }
 
+  public onConfirmDelete() {
+    if (this.getLayout().getVizPanels().length === 0) {
+      this.onDelete();
+      return;
+    }
+
+    if (this.getParentLayout().shouldUngroup()) {
+      this.onDelete();
+      return;
+    }
+
+    appEvents.publish(
+      new ShowConfirmModalEvent({
+        title: t('dashboard.rows-layout.delete-row-title', 'Delete row?'),
+        text: t(
+          'dashboard.rows-layout.delete-row-text',
+          'Deleting this row will also remove all panels. Are you sure you want to continue?'
+        ),
+        yesText: t('dashboard.rows-layout.delete-row-yes', 'Delete'),
+        onConfirm: () => {
+          this.onDelete();
+        },
+      })
+    );
+  }
+
   public createMultiSelectedElement(items: SceneObject[]): RowItems {
     return new RowItems(items.filter((item) => item instanceof RowItem));
   }
diff --git a/public/app/features/dashboard-scene/scene/layout-rows/RowsLayoutManager.tsx b/public/app/features/dashboard-scene/scene/layout-rows/RowsLayoutManager.tsx
index 4a99a719e5e..ad82737cb81 100644
--- a/public/app/features/dashboard-scene/scene/layout-rows/RowsLayoutManager.tsx
+++ b/public/app/features/dashboard-scene/scene/layout-rows/RowsLayoutManager.tsx
@@ -134,9 +134,13 @@ export class RowsLayoutManager extends SceneObjectBase<RowsLayoutManagerState> i
     });
   }
 
+  public shouldUngroup(): boolean {
+    return this.state.rows.length === 1;
+  }
+
   public removeRow(row: RowItem) {
     // When removing last row replace ourselves with the inner row layout
-    if (this.state.rows.length === 1) {
+    if (this.shouldUngroup()) {
       ungroupLayout(this, row.state.layout);
       return;
     }
diff --git a/public/app/features/dashboard-scene/scene/layout-tabs/TabItem.tsx b/public/app/features/dashboard-scene/scene/layout-tabs/TabItem.tsx
index 0074347ebb2..f9eb4b5dddd 100644
--- a/public/app/features/dashboard-scene/scene/layout-tabs/TabItem.tsx
+++ b/public/app/features/dashboard-scene/scene/layout-tabs/TabItem.tsx
@@ -10,10 +10,12 @@ import {
 } from '@grafana/scenes';
 import { TabsLayoutTabKind } from '@grafana/schema/dist/esm/schema/dashboard/v2alpha1/types.spec.gen';
 import { LS_TAB_COPY_KEY } from 'app/core/constants';
+import { appEvents } from 'app/core/core';
 import { t } from 'app/core/internationalization';
 import store from 'app/core/store';
 import kbn from 'app/core/utils/kbn';
 import { OptionsPaneCategoryDescriptor } from 'app/features/dashboard/components/PanelEditor/OptionsPaneCategoryDescriptor';
+import { ShowConfirmModalEvent } from 'app/types/events';
 
 import { ConditionalRendering } from '../../conditional-rendering/ConditionalRendering';
 import { serializeTab } from '../../serialization/layoutSerializers/TabsLayoutSerializer';
@@ -107,10 +109,38 @@ export class TabItem
   }
 
   public onDelete() {
-    const layout = sceneGraph.getAncestor(this, TabsLayoutManager);
+    const layout = this.getParentLayout();
     layout.removeTab(this);
   }
 
+  public onConfirmDelete() {
+    const layout = this.getParentLayout();
+
+    if (layout.shouldUngroup()) {
+      layout.removeTab(this);
+      return;
+    }
+
+    if (this.getLayout().getVizPanels().length === 0) {
+      this.onDelete();
+      return;
+    }
+
+    appEvents.publish(
+      new ShowConfirmModalEvent({
+        title: t('dashboard.tabs-layout.delete-tab-title', 'Delete tab?'),
+        text: t(
+          'dashboard.tabs-layout.delete-tab-text',
+          'Deleting this tab will also remove all panels. Are you sure you want to continue?'
+        ),
+        yesText: t('dashboard.tabs-layout.delete-tab-yes', 'Delete'),
+        onConfirm: () => {
+          this.onDelete();
+        },
+      })
+    );
+  }
+
   public serialize(): TabsLayoutTabKind {
     return serializeTab(this);
   }
diff --git a/public/app/features/dashboard-scene/scene/layout-tabs/TabsLayoutManager.tsx b/public/app/features/dashboard-scene/scene/layout-tabs/TabsLayoutManager.tsx
index 5a22c6aaabf..194d49c1d11 100644
--- a/public/app/features/dashboard-scene/scene/layout-tabs/TabsLayoutManager.tsx
+++ b/public/app/features/dashboard-scene/scene/layout-tabs/TabsLayoutManager.tsx
@@ -152,10 +152,15 @@ export class TabsLayoutManager extends SceneObjectBase<TabsLayoutManagerState> i
     this.state.tabs.forEach((tab) => tab.getLayout().activateRepeaters?.());
   }
 
+  public shouldUngroup(): boolean {
+    return this.state.tabs.length === 1;
+  }
+
   public removeTab(tabToRemove: TabItem) {
     // When removing last tab replace ourselves with the inner tab layout
-    if (this.state.tabs.length === 1) {
+    if (this.shouldUngroup()) {
       ungroupLayout(this, tabToRemove.state.layout);
+      return;
     }
 
     const currentTab = this.getCurrentTab();
diff --git a/public/app/features/dashboard-scene/scene/types/EditableDashboardElement.ts b/public/app/features/dashboard-scene/scene/types/EditableDashboardElement.ts
index 3f22a6fd60f..3455eb42bff 100644
--- a/public/app/features/dashboard-scene/scene/types/EditableDashboardElement.ts
+++ b/public/app/features/dashboard-scene/scene/types/EditableDashboardElement.ts
@@ -30,6 +30,11 @@ export interface EditableDashboardElement {
    */
   onDelete?(): void;
 
+  /**
+   * Should confirm delete action
+   */
+  onConfirmDelete?(): void;
+
   /**
    * Supports duplicate action
    */
diff --git a/public/locales/en-US/grafana.json b/public/locales/en-US/grafana.json
index d0892ab1856..60d4da1ad59 100644
--- a/public/locales/en-US/grafana.json
+++ b/public/locales/en-US/grafana.json
@@ -2775,6 +2775,10 @@
     "edit-pane": {
       "elements": {
         "dashboard": "Dashboard",
+        "multiple-elements": "Multiple elements",
+        "multiple-elements-delete-text": "Are you sure you want to delete these elements?",
+        "multiple-panels": "Multiple panels",
+        "multiple-panels-delete-text": "Are you sure you want to delete these panels? All queries will be removed.",
         "objects": "Objects",
         "panel": "Panel",
         "panels": "Panels",
@@ -2973,6 +2977,9 @@
       "title-row-options": "Row options"
     },
     "rows-layout": {
+      "delete-row-text": "Deleting this row will also remove all panels. Are you sure you want to continue?",
+      "delete-row-title": "Delete row?",
+      "delete-row-yes": "Delete",
       "description": "Collapsable panel groups with headings",
       "header-hidden-tooltip": "Row header only visible in edit mode",
       "name": "Rows",
@@ -3047,6 +3054,9 @@
       "aria-label-template-variables": "Template variables"
     },
     "tabs-layout": {
+      "delete-tab-text": "Deleting this tab will also remove all panels. Are you sure you want to continue?",
+      "delete-tab-title": "Delete tab?",
+      "delete-tab-yes": "Delete",
       "description": "Organize panels into horizontal tabs",
       "name": "Tabs",
       "tab": {
@@ -3257,6 +3267,9 @@
       "title-close": "Close"
     },
     "viz-panel": {
+      "delete-panel-text": "Deleting this panel will also remove all queries. Are you sure you want to continue?",
+      "delete-panel-title": "Delete panel?",
+      "delete-panel-yes": "Delete",
       "options": {
         "configure-button-tooltip": "Edit queries and visualization options",
         "description": "Description",