This works!

public/app/core/utils/fetch.ts

@@ -74,7 +74,10 @@ export const isContentTypeApplicationJson = (headers: Headers) => {
   }
 
   const contentType = headers.get('content-type');
-  if (contentType && contentType.toLowerCase() === 'application/json') {
+  if (
+    contentType &&
+    (contentType.toLowerCase() === 'application/json' || contentType.toLowerCase() === 'application/json-patch+json')
+  ) {
     return true;
   }
 

public/app/features/explore/QueryLibrary/QueryTemplateForm.tsx

@@ -1,3 +1,4 @@
+import { Observer, deepClone, generate, observe } from 'fast-json-patch';
 import { useForm } from 'react-hook-form';
 import { useAsync } from 'react-use';
 
@@ -103,8 +104,12 @@ export const QueryTemplateForm = ({ onCancel, onSave, queryToAdd, templateData }
     const temporaryDefaultTitle =
       data.description || t('explore.query-library.default-description', 'Public', { timestamp: timestamp });
 
-    if (templateData?.uid) {
+    if (templateData?.fullSpec && templateData.uid) {
-      handleEditQueryTemplate({ uid: templateData.uid, partialSpec: { title: data.description } }).then((isSuccess) => {
+      const docCopy: DataQueryFullSpec = deepClone(templateData.fullSpec);
+      const observer: Observer<DataQueryFullSpec> = observe(docCopy);
+      docCopy.spec.title = data.description;
+      const patch = generate(observer);
+      handleEditQueryTemplate({ uid: templateData.uid, jsonPatch: patch }).then((isSuccess) => {
         onSave(isSuccess);
       });
     } else if (queryToAdd) {

public/app/features/query-library/api/factory.ts

@@ -33,7 +33,7 @@ export const queryLibraryApi = createApi({
       query: (editQueryTemplateCommand) => ({
         url: `${editQueryTemplateCommand.uid}`,
         method: 'PATCH',
-        data: [{ op: 'replace', path: '/spec/title', value: editQueryTemplateCommand.partialSpec.title }],
+        data: editQueryTemplateCommand.jsonPatch,
       }),
       invalidatesTags: ['QueryTemplatesList'],
     }),

public/app/features/query-library/api/query.ts

@@ -27,6 +27,7 @@ export const BASE_URL = `/apis/${API_VERSION}/namespaces/default/querytemplates/
 // URL is optional for these requests
 interface QueryLibraryBackendRequest extends Pick<BackendSrvRequest, 'data' | 'method'> {
   url?: string;
+  jsonFormat?: boolean;
 }
 
 /**
@@ -41,6 +42,9 @@ export const baseQuery: BaseQueryFn<QueryLibraryBackendRequest, DataQuerySpecRes
       showErrorAlert: true,
       method: requestOptions.method || 'GET',
       data: requestOptions.data,
+      headers: {
+        'Content-type': 'application/json-patch+json',
+      },
     });
     return await lastValueFrom(responseObservable);
   } catch (error) {

public/app/features/query-library/types.ts

@@ -1,3 +1,5 @@
+import { Operation, ReplaceOperation } from 'fast-json-patch';
+
 import { DataQuery } from '@grafana/schema';
 
 import { DataQueryFullSpec, DataQueryPartialSpec } from './api/types';
@@ -18,7 +20,7 @@ export type AddQueryTemplateCommand = {
 
 export type EditQueryTemplateCommand = {
   uid: string;
-  partialSpec: DataQueryPartialSpec;
+  jsonPatch: Operation[];
 };
 
 export type DeleteQueryTemplateCommand = {