diff --git a/public/app/features/query/components/QueryEditorRow.test.tsx b/public/app/features/query/components/QueryEditorRow.test.tsx
index e87dd718b95..f839e570819 100644
--- a/public/app/features/query/components/QueryEditorRow.test.tsx
+++ b/public/app/features/query/components/QueryEditorRow.test.tsx
@@ -4,6 +4,7 @@ import { PropsWithChildren } from 'react';
 import { CoreApp, DataQueryRequest, dateTime, LoadingState, PanelData, toDataFrame } from '@grafana/data';
 import { DataQuery } from '@grafana/schema';
 import { mockDataSource } from 'app/features/alerting/unified/mocks';
+import { ExpressionDatasourceUID } from 'app/features/expressions/types';
 
 import { filterPanelDataToQuery, Props, QueryEditorRow } from './QueryEditorRow';
 
@@ -464,5 +465,28 @@ describe('QueryEditorRow', () => {
         expect(screen.queryByText('Replace with saved query')).not.toBeInTheDocument();
       });
     });
+
+    it('should not render saved queries buttons when query is an expression query', async () => {
+      const expressionQuery = {
+        refId: 'B',
+        datasource: {
+          uid: ExpressionDatasourceUID,
+          type: '__expr__',
+        },
+      };
+
+      const expressionProps = {
+        ...props(testData),
+        query: expressionQuery,
+        queries: [expressionQuery],
+      };
+
+      render(<QueryEditorRow {...expressionProps} />);
+
+      await waitFor(() => {
+        expect(screen.queryByText('Save query')).not.toBeInTheDocument();
+        expect(screen.queryByText('Replace with saved query')).not.toBeInTheDocument();
+      });
+    });
   });
 });
diff --git a/public/app/features/query/components/QueryEditorRow.tsx b/public/app/features/query/components/QueryEditorRow.tsx
index fb469d17aa7..fe8fa6c018e 100644
--- a/public/app/features/query/components/QueryEditorRow.tsx
+++ b/public/app/features/query/components/QueryEditorRow.tsx
@@ -34,6 +34,7 @@ import {
 } from 'app/core/components/QueryOperationRow/QueryOperationRow';
 
 import { useQueryLibraryContext } from '../../explore/QueryLibrary/QueryLibraryContext';
+import { ExpressionDatasourceUID } from '../../expressions/types';
 
 import { QueryActionComponent, RowActionComponents } from './QueryActionComponent';
 import { QueryEditorRowHeader } from './QueryEditorRowHeader';
@@ -386,10 +387,11 @@ export class QueryEditorRow<TQuery extends DataQuery> extends PureComponent<Prop
     const hasEditorHelp = datasource?.components?.QueryEditorHelp;
     const isEditingQueryLibrary = queryLibraryRef !== undefined;
     const isUnifiedAlerting = app === CoreApp.UnifiedAlerting;
+    const isExpressionQuery = query.datasource?.uid === ExpressionDatasourceUID;
 
     return (
       <>
-        {!isEditingQueryLibrary && !isUnifiedAlerting && (
+        {!isEditingQueryLibrary && !isUnifiedAlerting && !isExpressionQuery && (
           <SavedQueryButtons
             query={query}
             app={app}