diff --git a/public/app/features/explore/hooks/useKeyboardShortcuts.ts b/public/app/features/explore/hooks/useKeyboardShortcuts.ts
index 9ff1e32e5ed..47487690878 100644
--- a/public/app/features/explore/hooks/useKeyboardShortcuts.ts
+++ b/public/app/features/explore/hooks/useKeyboardShortcuts.ts
@@ -3,9 +3,19 @@ import { Unsubscribable } from 'rxjs';
 
 import { getAppEvents } from '@grafana/runtime';
 import { useGrafana } from 'app/core/context/GrafanaContext';
-import { AbsoluteTimeEvent, CopyTimeEvent, PasteTimeEvent, ShiftTimeEvent, ZoomOutEvent } from 'app/types/events';
+import { getState } from 'app/store/store';
+import {
+  AbsoluteTimeEvent,
+  CopyTimeEvent,
+  PasteTimeEvent,
+  RunQueriesEvent,
+  ShiftTimeEvent,
+  ZoomOutEvent,
+} from 'app/types/events';
 import { useDispatch } from 'app/types/store';
 
+import { runQueries } from '../state/query';
+import { selectPanesEntries } from '../state/selectors';
 import {
   copyTimeRangeToClipboard,
   makeAbsoluteTime,
@@ -21,8 +31,23 @@ export function useKeyboardShortcuts() {
   useEffect(() => {
     keybindings.setupTimeRangeBindings(false);
 
+    // Explore-specific: run queries shortcut
+    keybindings.bind('e r', () => {
+      getAppEvents().publish(new RunQueriesEvent());
+    });
+
     const tearDown: Unsubscribable[] = [];
 
+    tearDown.push(
+      getAppEvents().subscribe(RunQueriesEvent, () => {
+        // Read panes at event time to avoid re-subscribing when panes change
+        const panes = selectPanesEntries(getState());
+        panes.forEach(([exploreId]) => {
+          dispatch(runQueries({ exploreId }));
+        });
+      })
+    );
+
     tearDown.push(
       getAppEvents().subscribe(AbsoluteTimeEvent, () => {
         dispatch(makeAbsoluteTime());
@@ -54,6 +79,7 @@ export function useKeyboardShortcuts() {
     );
 
     return () => {
+      keybindings.unbind('e r');
       tearDown.forEach((u) => u.unsubscribe());
     };
   }, [dispatch, keybindings]);
diff --git a/public/app/types/events.ts b/public/app/types/events.ts
index 6fb728bb94c..95fbecc1e2d 100644
--- a/public/app/types/events.ts
+++ b/public/app/types/events.ts
@@ -159,6 +159,10 @@ export class AbsoluteTimeEvent extends BusEventWithPayload<AbsoluteTimeEventPayl
   static type = 'absolute-time';
 }
 
+export class RunQueriesEvent extends BusEventBase {
+  static type = 'run-queries';
+}
+
 export class RemovePanelEvent extends BusEventWithPayload<number> {
   static type = 'remove-panel';
 }
diff --git a/public/test/mocks/getGrafanaContextMock.ts b/public/test/mocks/getGrafanaContextMock.ts
index 64e704986b7..aa1d061f7fe 100644
--- a/public/test/mocks/getGrafanaContextMock.ts
+++ b/public/test/mocks/getGrafanaContextMock.ts
@@ -19,6 +19,8 @@ export function getGrafanaContextMock(overrides: Partial<GrafanaContextType> = {
       clearAndInitGlobalBindings: jest.fn(),
       setupDashboardBindings: jest.fn(),
       setupTimeRangeBindings: jest.fn(),
+      bind: jest.fn(),
+      unbind: jest.fn(),
     } as unknown as KeybindingSrv,
     newAssetsChecker: {
       start: jest.fn(),