diff --git a/public/app/plugins/datasource/prometheus/querybuilder/PromQueryModeller.test.ts b/public/app/plugins/datasource/prometheus/querybuilder/PromQueryModeller.test.ts
index cdf8c5e4a50..d4ef1582682 100644
--- a/public/app/plugins/datasource/prometheus/querybuilder/PromQueryModeller.test.ts
+++ b/public/app/plugins/datasource/prometheus/querybuilder/PromQueryModeller.test.ts
@@ -258,26 +258,6 @@ describe('PromQueryModeller', () => {
     ).toBe('(metric_a * 1000) / metric_b');
   });
 
-  it('Can render with binary queries with vectorMatches expression', () => {
-    expect(
-      modeller.renderQuery({
-        metric: 'metric_a',
-        labels: [],
-        operations: [],
-        binaryQueries: [
-          {
-            operator: '/',
-            vectorMatches: 'on(le)',
-            query: {
-              metric: 'metric_b',
-              labels: [],
-              operations: [],
-            },
-          },
-        ],
-      })
-    ).toBe('metric_a / on(le) metric_b');
-  });
   it('Can render functions that require a range as a parameter', () => {
     expect(
       modeller.renderQuery({
@@ -305,6 +285,7 @@ describe('PromQueryModeller', () => {
       })
     ).toBe('label_join(metric_a, "label_1", ",", "label_2")');
   });
+
   it('Can render label_join with extra parameters', () => {
     expect(
       modeller.renderQuery({
@@ -314,4 +295,26 @@ describe('PromQueryModeller', () => {
       })
     ).toBe('label_join(metric_a, "label_1", ", ", "label_2", "label_3", "label_4", "label_5")');
   });
+
+  it('can render vector matchers', () => {
+    expect(
+      modeller.renderQuery({
+        metric: 'metric_a',
+        labels: [],
+        operations: [],
+        binaryQueries: [
+          {
+            operator: '/',
+            vectorMatches: 'le, foo',
+            vectorMatchesType: 'on',
+            query: {
+              metric: 'metric_b',
+              labels: [],
+              operations: [],
+            },
+          },
+        ],
+      })
+    ).toBe('metric_a / on(le, foo) metric_b');
+  });
 });
diff --git a/public/app/plugins/datasource/prometheus/querybuilder/components/NestedQuery.tsx b/public/app/plugins/datasource/prometheus/querybuilder/components/NestedQuery.tsx
index 37c04f62e66..5c1780ad76f 100644
--- a/public/app/plugins/datasource/prometheus/querybuilder/components/NestedQuery.tsx
+++ b/public/app/plugins/datasource/prometheus/querybuilder/components/NestedQuery.tsx
@@ -37,18 +37,35 @@ export const NestedQuery = React.memo<Props>(({ nestedQuery, index, datasource,
           }}
         />
         <div className={styles.name}>Vector matches</div>
-
-        <AutoSizeInput
-          minWidth={20}
-          defaultValue={nestedQuery.vectorMatches}
-          onCommitChange={(evt) => {
-            onChange(index, {
-              ...nestedQuery,
-              vectorMatches: evt.currentTarget.value,
-            });
-          }}
-        />
-
+        <div className={styles.vectorMatchWrapper}>
+          <Select<PromVisualQueryBinary['vectorMatchesType']>
+            width="auto"
+            value={nestedQuery.vectorMatchesType || 'on'}
+            allowCustomValue
+            options={[
+              { value: 'on', label: 'on' },
+              { value: 'ignoring', label: 'ignoring' },
+            ]}
+            onChange={(val) => {
+              onChange(index, {
+                ...nestedQuery,
+                vectorMatchesType: val.value,
+              });
+            }}
+          />
+          <AutoSizeInput
+            className={styles.vectorMatchInput}
+            minWidth={20}
+            defaultValue={nestedQuery.vectorMatches}
+            onCommitChange={(evt) => {
+              onChange(index, {
+                ...nestedQuery,
+                vectorMatches: evt.currentTarget.value,
+                vectorMatchesType: nestedQuery.vectorMatchesType || 'on',
+              });
+            }}
+          />
+        </div>
         <FlexItem grow={1} />
         <IconButton name="times" size="sm" onClick={() => onRemove(index)} />
       </div>
@@ -76,21 +93,33 @@ NestedQuery.displayName = 'NestedQuery';
 const getStyles = (theme: GrafanaTheme2) => {
   return {
     card: css({
+      label: 'card',
       display: 'flex',
       flexDirection: 'column',
       gap: theme.spacing(0.5),
     }),
     header: css({
+      label: 'header',
       padding: theme.spacing(0.5, 0.5, 0.5, 1),
       gap: theme.spacing(1),
       display: 'flex',
       alignItems: 'center',
     }),
     name: css({
+      label: 'name',
       whiteSpace: 'nowrap',
     }),
     body: css({
+      label: 'body',
       paddingLeft: theme.spacing(2),
     }),
+    vectorMatchInput: css({
+      label: 'vectorMatchInput',
+      marginLeft: -1,
+    }),
+    vectorMatchWrapper: css({
+      label: 'vectorMatchWrapper',
+      display: 'flex',
+    }),
   };
 };
diff --git a/public/app/plugins/datasource/prometheus/querybuilder/parsing.test.ts b/public/app/plugins/datasource/prometheus/querybuilder/parsing.test.ts
index b4dc7919841..89643c4b3a6 100644
--- a/public/app/plugins/datasource/prometheus/querybuilder/parsing.test.ts
+++ b/public/app/plugins/datasource/prometheus/querybuilder/parsing.test.ts
@@ -505,6 +505,42 @@ describe('buildVisualQueryFromString', () => {
       },
     });
   });
+
+  it('handles binary operation with vector matchers', () => {
+    expect(buildVisualQueryFromString('foo * on(foo, bar) metric')).toEqual({
+      errors: [],
+      query: {
+        metric: 'foo',
+        labels: [],
+        operations: [],
+        binaryQueries: [
+          {
+            operator: '*',
+            vectorMatches: 'foo, bar',
+            vectorMatchesType: 'on',
+            query: { metric: 'metric', labels: [], operations: [] },
+          },
+        ],
+      },
+    });
+
+    expect(buildVisualQueryFromString('foo * ignoring(foo) metric')).toEqual({
+      errors: [],
+      query: {
+        metric: 'foo',
+        labels: [],
+        operations: [],
+        binaryQueries: [
+          {
+            operator: '*',
+            vectorMatches: 'foo',
+            vectorMatchesType: 'ignoring',
+            query: { metric: 'metric', labels: [], operations: [] },
+          },
+        ],
+      },
+    });
+  });
 });
 
 function noErrors(query: PromVisualQuery) {
diff --git a/public/app/plugins/datasource/prometheus/querybuilder/parsing.ts b/public/app/plugins/datasource/prometheus/querybuilder/parsing.ts
index c6cb0488b42..eb71fb5688b 100644
--- a/public/app/plugins/datasource/prometheus/querybuilder/parsing.ts
+++ b/public/app/plugins/datasource/prometheus/querybuilder/parsing.ts
@@ -1,7 +1,7 @@
 import { parser } from 'lezer-promql';
 import { SyntaxNode, TreeCursor } from '@lezer/common';
 import { QueryBuilderLabelFilter, QueryBuilderOperation } from './shared/types';
-import { PromVisualQuery } from './types';
+import { PromVisualQuery, PromVisualQueryBinary } from './types';
 import { binaryScalarDefs } from './binaryScalarOperations';
 
 // Taken from template_srv, but copied so to not mess with the regex.index which is manipulated in the service
@@ -342,7 +342,8 @@ function handleBinary(expr: string, node: SyntaxNode, context: Context) {
   const visQuery = context.query;
   const left = node.firstChild!;
   const op = getString(expr, left.nextSibling);
-  const binModifier = node.getChild('BinModifiers')?.getChild('Bool');
+  const binModifier = getBinaryModifier(expr, node.getChild('BinModifiers'));
+
   const right = node.lastChild!;
 
   const opDef = operatorToOpName[op];
@@ -362,13 +363,13 @@ function handleBinary(expr: string, node: SyntaxNode, context: Context) {
   }
 
   if (rightNumber) {
-    visQuery.operations.push(makeBinOp(opDef, expr, right, binModifier));
+    visQuery.operations.push(makeBinOp(opDef, expr, right, !!binModifier?.isBool));
   } else if (rightBinary) {
     // Due to the way binary ops are parsed we can get a binary operation on the right that starts with a number which
     // is a factor for a current binary operation. So we have to add it as an operation now.
     const leftMostChild = getLeftMostChild(right);
     if (leftMostChild?.name === 'NumberLiteral') {
-      visQuery.operations.push(makeBinOp(opDef, expr, leftMostChild, binModifier));
+      visQuery.operations.push(makeBinOp(opDef, expr, leftMostChild, !!binModifier?.isBool));
     }
 
     // If we added the first number literal as operation here we still can continue and handle the rest as the first
@@ -376,7 +377,7 @@ function handleBinary(expr: string, node: SyntaxNode, context: Context) {
     handleExpression(expr, right, context);
   } else {
     visQuery.binaryQueries = visQuery.binaryQueries || [];
-    const binQuery = {
+    const binQuery: PromVisualQueryBinary = {
       operator: op,
       query: {
         metric: '',
@@ -384,6 +385,10 @@ function handleBinary(expr: string, node: SyntaxNode, context: Context) {
         operations: [],
       },
     };
+    if (binModifier?.isMatcher) {
+      binQuery.vectorMatchesType = binModifier.matchType;
+      binQuery.vectorMatches = binModifier.matches;
+    }
     visQuery.binaryQueries.push(binQuery);
     handleExpression(expr, right, {
       query: binQuery.query,
@@ -392,15 +397,43 @@ function handleBinary(expr: string, node: SyntaxNode, context: Context) {
   }
 }
 
+function getBinaryModifier(
+  expr: string,
+  node: SyntaxNode | null
+):
+  | { isBool: true; isMatcher: false }
+  | { isBool: false; isMatcher: true; matches: string; matchType: 'ignoring' | 'on' }
+  | undefined {
+  if (!node) {
+    return undefined;
+  }
+  if (node.getChild('Bool')) {
+    return { isBool: true, isMatcher: false };
+  } else {
+    const matcher = node.getChild('OnOrIgnoring');
+    if (!matcher) {
+      // Not sure what this could be, maybe should be an error.
+      return undefined;
+    }
+    const labels = getString(expr, matcher.getChild('GroupingLabels')?.getChild('GroupingLabelList'));
+    return {
+      isMatcher: true,
+      isBool: false,
+      matches: labels,
+      matchType: matcher.getChild('On') ? 'on' : 'ignoring',
+    };
+  }
+}
+
 function makeBinOp(
   opDef: { id: string; comparison?: boolean },
   expr: string,
   numberNode: SyntaxNode,
-  binModifier?: SyntaxNode | null
+  hasBool: boolean
 ) {
   const params: any[] = [parseFloat(getString(expr, numberNode))];
   if (opDef.comparison) {
-    params.unshift(Boolean(binModifier));
+    params.unshift(hasBool);
   }
   return {
     id: opDef.id,
@@ -414,7 +447,7 @@ function makeBinOp(
  * @param expr
  * @param node
  */
-function getString(expr: string, node: SyntaxNode | TreeCursor | null) {
+function getString(expr: string, node: SyntaxNode | TreeCursor | null | undefined) {
   if (!node) {
     return '';
   }
diff --git a/public/app/plugins/datasource/prometheus/querybuilder/shared/LokiAndPromQueryModellerBase.ts b/public/app/plugins/datasource/prometheus/querybuilder/shared/LokiAndPromQueryModellerBase.ts
index 1871b7a2a44..f2b0a94fa67 100644
--- a/public/app/plugins/datasource/prometheus/querybuilder/shared/LokiAndPromQueryModellerBase.ts
+++ b/public/app/plugins/datasource/prometheus/querybuilder/shared/LokiAndPromQueryModellerBase.ts
@@ -9,6 +9,7 @@ import {
 
 export interface VisualQueryBinary<T> {
   operator: string;
+  vectorMatchesType?: 'on' | 'ignoring';
   vectorMatches?: string;
   query: T;
 }
@@ -66,7 +67,7 @@ export abstract class LokiAndPromQueryModellerBase<T extends QueryWithOperations
     let result = leftOperand + ` ${binaryQuery.operator} `;
 
     if (binaryQuery.vectorMatches) {
-      result += `${binaryQuery.vectorMatches} `;
+      result += `${binaryQuery.vectorMatchesType}(${binaryQuery.vectorMatches}) `;
     }
 
     return result + this.renderQuery(binaryQuery.query, true);