diff --git a/packages/grafana-ui/src/components/Combobox/Combobox.test.tsx b/packages/grafana-ui/src/components/Combobox/Combobox.test.tsx
index 537e26df1c9..b99e58a447b 100644
--- a/packages/grafana-ui/src/components/Combobox/Combobox.test.tsx
+++ b/packages/grafana-ui/src/components/Combobox/Combobox.test.tsx
@@ -6,6 +6,7 @@ import { Field } from '../Forms/Field';
 
 import { Combobox } from './Combobox';
 import { ComboboxOption } from './types';
+import { DEBOUNCE_TIME_MS } from './useOptions';
 
 // Mock data for the Combobox options
 const options: ComboboxOption[] = [
@@ -613,6 +614,23 @@ describe('Combobox', () => {
         expect(onChangeHandler).not.toHaveBeenCalled();
         expect(input).toHaveValue('Option 1');
       });
+
+      it('shows loading message', async () => {
+        const loadingMessage = 'Loading options...';
+        const asyncOptions = jest.fn(() => Promise.resolve(simpleAsyncOptions));
+        render(<Combobox options={asyncOptions} onChange={onChangeHandler} />);
+
+        const input = screen.getByRole('combobox');
+        await user.click(input);
+
+        await act(async () => jest.advanceTimersByTime(0));
+
+        expect(await screen.findByText(loadingMessage)).toBeInTheDocument();
+
+        await act(async () => jest.advanceTimersByTime(DEBOUNCE_TIME_MS));
+
+        expect(screen.queryByText(loadingMessage)).not.toBeInTheDocument();
+      });
     });
   });
 
diff --git a/packages/grafana-ui/src/components/Combobox/Combobox.tsx b/packages/grafana-ui/src/components/Combobox/Combobox.tsx
index b81d0e601fa..9c4de9c2d8b 100644
--- a/packages/grafana-ui/src/components/Combobox/Combobox.tsx
+++ b/packages/grafana-ui/src/components/Combobox/Combobox.tsx
@@ -1,7 +1,7 @@
 import { cx } from '@emotion/css';
 import { useVirtualizer, type Range } from '@tanstack/react-virtual';
 import { useCombobox } from 'downshift';
-import React, { useCallback, useId, useMemo } from 'react';
+import React, { ComponentProps, useCallback, useId, useMemo } from 'react';
 
 import { t } from '@grafana/i18n';
 
@@ -60,6 +60,11 @@ interface ComboboxStaticProps<T extends string | number>
    * Called when the input loses focus.
    */
   onBlur?: () => void;
+
+  /**
+   * Icon to display at the start of the ComboBox input
+   */
+  prefixIcon?: ComponentProps<typeof Icon>['name'];
 }
 
 interface ClearableProps<T extends string | number> {
@@ -137,6 +142,7 @@ export const Combobox = <T extends string | number>(props: ComboboxProps<T>) =>
     disabled,
     portalContainer,
     invalid,
+    prefixIcon,
   } = props;
 
   // Value can be an actual scalar Value (string or number), or an Option (value + label), so
@@ -376,6 +382,7 @@ export const Combobox = <T extends string | number>(props: ComboboxProps<T>) =>
         {...(isAutoSize ? { minWidth, maxWidth } : {})}
         autoFocus={autoFocus}
         onBlur={onBlur}
+        prefix={prefixIcon && <Icon name={prefixIcon} />}
         disabled={disabled}
         invalid={invalid}
         className={styles.input}
@@ -402,6 +409,7 @@ export const Combobox = <T extends string | number>(props: ComboboxProps<T>) =>
         >
           {isOpen && (
             <ComboboxList
+              loading={loading}
               options={filteredOptions}
               highlightedIndex={highlightedIndex}
               selectedItems={selectedItem ? [selectedItem] : []}
diff --git a/packages/grafana-ui/src/components/Combobox/ComboboxList.tsx b/packages/grafana-ui/src/components/Combobox/ComboboxList.tsx
index 626418213ff..bc738338204 100644
--- a/packages/grafana-ui/src/components/Combobox/ComboboxList.tsx
+++ b/packages/grafana-ui/src/components/Combobox/ComboboxList.tsx
@@ -7,7 +7,7 @@ import { useStyles2 } from '../../themes/ThemeContext';
 import { Checkbox } from '../Forms/Checkbox';
 import { ScrollContainer } from '../ScrollContainer/ScrollContainer';
 
-import { AsyncError, NotFoundError } from './MessageRows';
+import { AsyncError, LoadingOptions, NotFoundError } from './MessageRows';
 import { getComboboxStyles, MENU_OPTION_HEIGHT, MENU_OPTION_HEIGHT_DESCRIPTION } from './getComboboxStyles';
 import { ALL_OPTION_VALUE, ComboboxOption } from './types';
 import { isNewGroup } from './utils';
@@ -23,6 +23,7 @@ interface ComboboxListProps<T extends string | number> {
   enableAllOption?: boolean;
   isMultiSelect?: boolean;
   error?: boolean;
+  loading?: boolean;
 }
 
 export const ComboboxList = <T extends string | number>({
@@ -34,6 +35,7 @@ export const ComboboxList = <T extends string | number>({
   enableAllOption,
   isMultiSelect = false,
   error = false,
+  loading = false,
 }: ComboboxListProps<T>) => {
   const styles = useStyles2(getComboboxStyles);
 
@@ -161,7 +163,8 @@ export const ComboboxList = <T extends string | number>({
 
       <div aria-live="polite">
         {error && <AsyncError />}
-        {options.length === 0 && !error && <NotFoundError />}
+        {!loading && options.length === 0 && !error && <NotFoundError />}
+        {loading && options.length === 0 && <LoadingOptions />}
       </div>
     </ScrollContainer>
   );
diff --git a/packages/grafana-ui/src/components/Combobox/MessageRows.tsx b/packages/grafana-ui/src/components/Combobox/MessageRows.tsx
index a2d45162c01..46f2a5e4cc3 100644
--- a/packages/grafana-ui/src/components/Combobox/MessageRows.tsx
+++ b/packages/grafana-ui/src/components/Combobox/MessageRows.tsx
@@ -22,6 +22,12 @@ export const NotFoundError = () => (
   </MessageRow>
 );
 
+export const LoadingOptions = () => (
+  <MessageRow>
+    <Trans i18nKey="combobox.options.loading">Loading options...</Trans>
+  </MessageRow>
+);
+
 const MessageRow = ({ children }: { children: ReactNode }) => {
   return (
     <Box padding={2}>
diff --git a/packages/grafana-ui/src/components/Combobox/MultiCombobox.test.tsx b/packages/grafana-ui/src/components/Combobox/MultiCombobox.test.tsx
index 572a9d865a0..2061087828d 100644
--- a/packages/grafana-ui/src/components/Combobox/MultiCombobox.test.tsx
+++ b/packages/grafana-ui/src/components/Combobox/MultiCombobox.test.tsx
@@ -4,6 +4,7 @@ import React from 'react';
 
 import { MultiCombobox, MultiComboboxProps } from './MultiCombobox';
 import { ComboboxOption } from './types';
+import { DEBOUNCE_TIME_MS } from './useOptions';
 
 describe('MultiCombobox', () => {
   beforeAll(() => {
@@ -330,7 +331,7 @@ describe('MultiCombobox', () => {
       await user.click(input);
 
       // Debounce
-      await act(async () => jest.advanceTimersByTime(200));
+      await act(async () => jest.advanceTimersByTime(DEBOUNCE_TIME_MS));
 
       expect(asyncOptions).toHaveBeenCalled();
     });
@@ -380,10 +381,10 @@ describe('MultiCombobox', () => {
       await user.click(input);
 
       await user.keyboard('a');
-      act(() => jest.advanceTimersByTime(200)); // Skip debounce
+      act(() => jest.advanceTimersByTime(DEBOUNCE_TIME_MS)); // Skip debounce
 
       await user.keyboard('b');
-      act(() => jest.advanceTimersByTime(200)); // Skip debounce
+      act(() => jest.advanceTimersByTime(DEBOUNCE_TIME_MS)); // Skip debounce
 
       await user.keyboard('c');
       act(() => jest.advanceTimersByTime(500)); // Resolve the second request, should be ignored
@@ -422,7 +423,7 @@ describe('MultiCombobox', () => {
       act(() => jest.advanceTimersByTime(10));
 
       await user.keyboard('c');
-      act(() => jest.advanceTimersByTime(200));
+      act(() => jest.advanceTimersByTime(DEBOUNCE_TIME_MS));
 
       const item = await screen.findByRole('option', { name: 'Option 3' });
       expect(item).toBeInTheDocument();
@@ -439,7 +440,7 @@ describe('MultiCombobox', () => {
       await user.click(input);
 
       // Debounce
-      await act(async () => jest.advanceTimersByTime(200));
+      await act(async () => jest.advanceTimersByTime(DEBOUNCE_TIME_MS));
 
       // Click on Option 1 to deselect it (it should already be selected via value prop)
       const item = await screen.findByRole('option', { name: 'Option 1' });
@@ -484,7 +485,7 @@ describe('MultiCombobox', () => {
       await user.click(input);
 
       // Wait for async options to load
-      await act(async () => jest.advanceTimersByTime(200));
+      await act(async () => jest.advanceTimersByTime(DEBOUNCE_TIME_MS));
 
       // Integration A should be selected (shown as pill)
       const pillRemoveButton = screen.getByRole('button', { name: 'Remove Integration A' });
@@ -500,6 +501,23 @@ describe('MultiCombobox', () => {
       // The pill should be removed
       expect(screen.queryByRole('button', { name: 'Remove Integration A' })).not.toBeInTheDocument();
     });
+
+    it('shows loading message', async () => {
+      const loadingMessage = 'Loading options...';
+      const asyncOptions = jest.fn(() => Promise.resolve(simpleAsyncOptions));
+      render(<MultiCombobox options={asyncOptions} value={['Option 1']} onChange={onChangeHandler} />);
+
+      const input = screen.getByRole('combobox');
+      await user.click(input);
+
+      await act(async () => jest.advanceTimersByTime(0));
+
+      expect(await screen.findByText(loadingMessage)).toBeInTheDocument();
+
+      await act(async () => jest.advanceTimersByTime(DEBOUNCE_TIME_MS));
+
+      expect(screen.queryByText(loadingMessage)).not.toBeInTheDocument();
+    });
   });
 });
 
diff --git a/packages/grafana-ui/src/components/Combobox/MultiCombobox.tsx b/packages/grafana-ui/src/components/Combobox/MultiCombobox.tsx
index 13dd02742e4..989bf3d0e2e 100644
--- a/packages/grafana-ui/src/components/Combobox/MultiCombobox.tsx
+++ b/packages/grafana-ui/src/components/Combobox/MultiCombobox.tsx
@@ -51,6 +51,7 @@ export const MultiCombobox = <T extends string | number>(props: MultiComboboxPro
     'aria-labelledby': ariaLabelledBy,
     'data-testid': dataTestId,
     portalContainer,
+    prefixIcon,
   } = props;
 
   const styles = useStyles2(getComboboxStyles);
@@ -267,6 +268,13 @@ export const MultiCombobox = <T extends string | number>(props: MultiComboboxPro
   return (
     <div className={multiStyles.container} ref={containerRef}>
       <div className={cx(multiStyles.wrapper, { [multiStyles.disabled]: disabled })} ref={measureRef}>
+        {prefixIcon && (
+          <Box marginLeft={0.5}>
+            <Text color="secondary">
+              <Icon name={prefixIcon} />
+            </Text>
+          </Box>
+        )}
         <span className={multiStyles.pillWrapper}>
           {visibleItems.map((item, index) => (
             <ValuePill
@@ -347,6 +355,7 @@ export const MultiCombobox = <T extends string | number>(props: MultiComboboxPro
         >
           {isOpen && (
             <ComboboxList
+              loading={loading}
               options={options}
               highlightedIndex={highlightedIndex}
               selectedItems={selectedItems}
diff --git a/packages/grafana-ui/src/components/Combobox/getMultiComboboxStyles.ts b/packages/grafana-ui/src/components/Combobox/getMultiComboboxStyles.ts
index da77745e779..703030b951d 100644
--- a/packages/grafana-ui/src/components/Combobox/getMultiComboboxStyles.ts
+++ b/packages/grafana-ui/src/components/Combobox/getMultiComboboxStyles.ts
@@ -33,6 +33,7 @@ export const getMultiComboboxStyles = (
       inputStyles.input,
       css({
         display: 'flex',
+        alignItems: 'center',
         width: '100%',
         gap: theme.spacing(0.5),
         padding: theme.spacing(0.5),
diff --git a/packages/grafana-ui/src/components/Combobox/useOptions.ts b/packages/grafana-ui/src/components/Combobox/useOptions.ts
index 8b70f96b053..5a012cf02f6 100644
--- a/packages/grafana-ui/src/components/Combobox/useOptions.ts
+++ b/packages/grafana-ui/src/components/Combobox/useOptions.ts
@@ -16,6 +16,8 @@ type AsyncOptions<T extends string | number> =
 
 const asyncNoop = () => Promise.resolve([]);
 
+export const DEBOUNCE_TIME_MS = 200;
+
 /**
  * Abstracts away sync/async options for combobox components.
  * It also filters options based on the user's input.
@@ -49,7 +51,7 @@ export function useOptions<T extends string | number>(rawOptions: AsyncOptions<T
               }
             }
           });
-      }, 200),
+      }, DEBOUNCE_TIME_MS),
     [loadOptions]
   );
 
diff --git a/public/locales/en-US/grafana.json b/public/locales/en-US/grafana.json
index 092df4634f1..b0d349ab26b 100644
--- a/public/locales/en-US/grafana.json
+++ b/public/locales/en-US/grafana.json
@@ -4120,6 +4120,7 @@
       "description": "Use custom value"
     },
     "options": {
+      "loading": "Loading options...",
       "no-found": "No options found."
     }
   },