diff --git a/package.json b/package.json
index dd6ba11bc16..54a1d756b6c 100644
--- a/package.json
+++ b/package.json
@@ -271,6 +271,7 @@
     "@formatjs/intl-durationformat": "^0.7.0",
     "@glideapps/glide-data-grid": "^6.0.0",
     "@grafana/alerting": "workspace:*",
+    "@grafana/assistant": "0.0.7",
     "@grafana/aws-sdk": "0.7.1",
     "@grafana/azure-sdk": "0.0.7",
     "@grafana/data": "workspace:*",
diff --git a/public/app/features/logs/components/panel/LogLine.test.tsx b/public/app/features/logs/components/panel/LogLine.test.tsx
index e31ba38cabf..89803a457bb 100644
--- a/public/app/features/logs/components/panel/LogLine.test.tsx
+++ b/public/app/features/logs/components/panel/LogLine.test.tsx
@@ -14,6 +14,11 @@ import { defaultProps, defaultValue } from './__mocks__/LogListContext';
 import { LogListModel } from './processing';
 import { LogLineVirtualization } from './virtualization';
 
+jest.mock('@grafana/assistant', () => ({
+  ...jest.requireActual('@grafana/assistant'),
+  useAssistant: jest.fn(() => [true, jest.fn()]),
+}));
+
 jest.mock('./LogListContext');
 jest.mock('../LogDetails');
 
diff --git a/public/app/features/logs/components/panel/LogLineDetails.test.tsx b/public/app/features/logs/components/panel/LogLineDetails.test.tsx
index 2ce960fdd86..112ea2531ba 100644
--- a/public/app/features/logs/components/panel/LogLineDetails.test.tsx
+++ b/public/app/features/logs/components/panel/LogLineDetails.test.tsx
@@ -23,6 +23,13 @@ import { LogLineDetails, Props } from './LogLineDetails';
 import { LogListContext, LogListContextData } from './LogListContext';
 import { defaultValue } from './__mocks__/LogListContext';
 
+jest.mock('@grafana/assistant', () => {
+  return {
+    ...jest.requireActual('@grafana/assistant'),
+    useAssistant: jest.fn().mockReturnValue([true, jest.fn()]),
+  };
+});
+
 jest.mock('@grafana/runtime', () => {
   return {
     ...jest.requireActual('@grafana/runtime'),
diff --git a/public/app/features/logs/components/panel/LogLineDetailsHeader.tsx b/public/app/features/logs/components/panel/LogLineDetailsHeader.tsx
index a71b64fc31b..9a4e6eedce0 100644
--- a/public/app/features/logs/components/panel/LogLineDetailsHeader.tsx
+++ b/public/app/features/logs/components/panel/LogLineDetailsHeader.tsx
@@ -37,6 +37,8 @@ export const LogLineDetailsHeader = ({ focusLogLine, log, search, onSearch }: Pr
     onPinLine,
     onUnpinLine,
     wrapLogMessage,
+    isAssistantAvailable,
+    openAssistantByLog,
   } = useLogListContext();
   const pinned = useLogIsPinned(log);
   const styles = useStyles2(getStyles, detailsMode, wrapLogMessage);
@@ -149,6 +151,16 @@ export const LogLineDetailsHeader = ({ focusLogLine, log, search, onSearch }: Pr
         suffix={search !== '' ? clearSearch : undefined}
       />
       <div className={styles.icons}>
+        {isAssistantAvailable && (
+          <IconButton
+            tooltip={t('logs.log-line-details.open-assistant', 'Explain this log line in Assistant')}
+            tooltipPlacement="top"
+            size="md"
+            name="ai-sparkle"
+            onClick={() => openAssistantByLog?.(log)}
+            tabIndex={0}
+          />
+        )}
         {focusLogLine && (
           <IconButton
             tooltip={t('logs.log-line-details.scroll-to-logline', 'Scroll to log line')}
diff --git a/public/app/features/logs/components/panel/LogLineMenu.test.tsx b/public/app/features/logs/components/panel/LogLineMenu.test.tsx
index a447d81c62f..a8c03ea385e 100644
--- a/public/app/features/logs/components/panel/LogLineMenu.test.tsx
+++ b/public/app/features/logs/components/panel/LogLineMenu.test.tsx
@@ -13,6 +13,16 @@ import { LogListModel } from './processing';
 
 jest.mock('./LogListContext');
 
+jest.mock('@grafana/assistant', () => ({
+  ...jest.requireActual('@grafana/assistant'),
+  useAssistant: jest.fn(() => [true, jest.fn()]),
+}));
+
+jest.mock('@grafana/runtime', () => ({
+  ...jest.requireActual('@grafana/runtime'),
+  isAssistantAvailable: true,
+}));
+
 const theme = createTheme();
 const styles = getStyles(theme);
 const contextProps = {
diff --git a/public/app/features/logs/components/panel/LogLineMenu.tsx b/public/app/features/logs/components/panel/LogLineMenu.tsx
index 37a0df589d6..49b55b368d1 100644
--- a/public/app/features/logs/components/panel/LogLineMenu.tsx
+++ b/public/app/features/logs/components/panel/LogLineMenu.tsx
@@ -1,4 +1,4 @@
-import { useCallback, useMemo, useRef, MouseEvent } from 'react';
+import { MouseEvent, useCallback, useMemo, useRef } from 'react';
 
 import { LogRowContextOptions, LogRowModel } from '@grafana/data';
 import { t } from '@grafana/i18n';
@@ -45,6 +45,8 @@ export const LogLineMenu = ({ log, styles }: Props) => {
     logLineMenuCustomItems = [],
     logSupportsContext,
     toggleDetails,
+    isAssistantAvailable,
+    openAssistantByLog,
   } = useLogListContext();
   const pinned = useLogIsPinned(log);
   const menuRef = useRef(null);
@@ -108,6 +110,13 @@ export const LogLineMenu = ({ log, styles }: Props) => {
         {onPermalinkClick && log.rowId !== undefined && log.uid && (
           <Menu.Item onClick={copyLinkToLogLine} label={t('logs.log-line-menu.copy-link', 'Copy link to log line')} />
         )}
+        {isAssistantAvailable && (
+          <Menu.Item
+            onClick={() => openAssistantByLog?.(log)}
+            icon="ai-sparkle"
+            label={t('logs.log-line-menu.open-assistant', 'Explain this log line in Assistant')}
+          />
+        )}
         {logLineMenuCustomItems.map((item, i) => {
           if (isDivider(item)) {
             return <Menu.Divider key={i} />;
@@ -134,6 +143,8 @@ export const LogLineMenu = ({ log, styles }: Props) => {
       showContext,
       toggleLogDetails,
       togglePinning,
+      isAssistantAvailable,
+      openAssistantByLog,
     ]
   );
 
diff --git a/public/app/features/logs/components/panel/LogList.test.tsx b/public/app/features/logs/components/panel/LogList.test.tsx
index 3d76e63e413..4f740d8059b 100644
--- a/public/app/features/logs/components/panel/LogList.test.tsx
+++ b/public/app/features/logs/components/panel/LogList.test.tsx
@@ -9,6 +9,11 @@ import { createLogRow } from '../mocks/logRow';
 
 import { LogList, Props } from './LogList';
 
+jest.mock('@grafana/assistant', () => ({
+  ...jest.requireActual('@grafana/assistant'),
+  useAssistant: jest.fn(() => [true, jest.fn()]),
+}));
+
 jest.mock('@grafana/runtime', () => {
   return {
     ...jest.requireActual('@grafana/runtime'),
diff --git a/public/app/features/logs/components/panel/LogListContext.tsx b/public/app/features/logs/components/panel/LogListContext.tsx
index 153c53a0a80..f2c7455fddb 100644
--- a/public/app/features/logs/components/panel/LogListContext.tsx
+++ b/public/app/features/logs/components/panel/LogListContext.tsx
@@ -11,6 +11,7 @@ import {
   useState,
 } from 'react';
 
+import { createContext as createAssistantContext, ItemDataType, useAssistant } from '@grafana/assistant';
 import {
   CoreApp,
   DataFrame,
@@ -22,10 +23,11 @@ import {
   shallowCompare,
   store,
 } from '@grafana/data';
-import { config, reportInteraction } from '@grafana/runtime';
+import { t } from '@grafana/i18n';
+import { config, getDataSourceSrv, reportInteraction } from '@grafana/runtime';
 import { PopoverContent } from '@grafana/ui';
 
-import { DownloadFormat, checkLogsError, checkLogsSampled, downloadLogs as download } from '../../utils';
+import { checkLogsError, checkLogsSampled, downloadLogs as download, DownloadFormat } from '../../utils';
 import { getDisplayedFieldsForLogs } from '../otel/formats';
 
 import { LogLineDetailsMode } from './LogLineDetails';
@@ -63,6 +65,8 @@ export interface LogListContextData extends Omit<Props, 'containerElement' | 'lo
   setWrapLogMessage: (showTime: boolean) => void;
   showDetails: LogListModel[];
   toggleDetails: (log: LogListModel) => void;
+  isAssistantAvailable: boolean;
+  openAssistantByLog: ((log: LogListModel) => void) | undefined;
 }
 
 export const LogListContext = createContext<LogListContextData>({
@@ -100,6 +104,8 @@ export const LogListContext = createContext<LogListContextData>({
   syntaxHighlighting: true,
   toggleDetails: () => {},
   wrapLogMessage: false,
+  isAssistantAvailable: false,
+  openAssistantByLog: () => {},
 });
 
 export const useLogListContextData = (key: keyof LogListContextData) => {
@@ -239,6 +245,47 @@ export const LogListContextProvider = ({
   const [showDetails, setShowDetails] = useState<LogListModel[]>([]);
   const [detailsWidth, setDetailsWidthState] = useState(getDetailsWidth(containerElement, logOptionsStorageKey));
   const [detailsMode, setDetailsMode] = useState<LogLineDetailsMode>(detailsModeProp ?? 'sidebar');
+  const [isAssistantAvailable, openAssistant] = useAssistant();
+
+  const openAssistantByLog = useCallback(
+    async (log: LogListModel) => {
+      if (!openAssistant) {
+        return;
+      }
+
+      const datasource = await getDataSourceSrv().get(log.datasourceUid);
+      const context = [];
+      if (datasource) {
+        context.push(
+          createAssistantContext(ItemDataType.Datasource, {
+            datasourceUid: datasource.uid,
+            datasourceName: datasource.name,
+            datasourceType: datasource.type,
+          })
+        );
+      }
+      openAssistant({
+        prompt: `${t('logs.log-line-menu.log-line-explainer', 'Explain this log line in a concise way')}:
+
+      \`\`\`
+${log.entry.replaceAll('`', '\\`')}
+      \`\`\`
+      `,
+        context: [
+          ...context,
+          createAssistantContext(ItemDataType.Structured, {
+            title: t('logs.log-line-menu.log-line', 'Log line'),
+            data: {
+              labels: log.labels,
+              value: log.entry,
+              timestamp: log.timestamp,
+            },
+          }),
+        ],
+      });
+    },
+    [openAssistant]
+  );
 
   useEffect(() => {
     if (noInteractions) {
@@ -569,6 +616,8 @@ export const LogListContextProvider = ({
         syntaxHighlighting: logListState.syntaxHighlighting,
         toggleDetails,
         wrapLogMessage: logListState.wrapLogMessage,
+        isAssistantAvailable,
+        openAssistantByLog,
       }}
     >
       {children}
diff --git a/public/app/features/logs/components/panel/LogListControls.test.tsx b/public/app/features/logs/components/panel/LogListControls.test.tsx
index db8e59134b0..2acdf38abe0 100644
--- a/public/app/features/logs/components/panel/LogListControls.test.tsx
+++ b/public/app/features/logs/components/panel/LogListControls.test.tsx
@@ -17,6 +17,13 @@ jest.mock('../../utils', () => ({
   downloadLogs: jest.fn(),
 }));
 
+jest.mock('@grafana/assistant', () => {
+  return {
+    ...jest.requireActual('@grafana/assistant'),
+    useAssistant: jest.fn().mockReturnValue([true, jest.fn()]),
+  };
+});
+
 const fontSize: LogListFontSize = 'default';
 const contextProps = {
   app: CoreApp.Unknown,
@@ -31,6 +38,8 @@ const contextProps = {
   sortOrder: LogsSortOrder.Ascending,
   syntaxHighlighting: false,
   wrapLogMessage: false,
+  isAssistantAvailable: false,
+  openAssistantByLog: () => {},
 };
 
 describe('LogListControls', () => {
diff --git a/public/app/features/logs/components/panel/__mocks__/LogListContext.tsx b/public/app/features/logs/components/panel/__mocks__/LogListContext.tsx
index 131afaa32cb..53b020bbe88 100644
--- a/public/app/features/logs/components/panel/__mocks__/LogListContext.tsx
+++ b/public/app/features/logs/components/panel/__mocks__/LogListContext.tsx
@@ -7,6 +7,13 @@ import { LogLineDetailsMode } from '../LogLineDetails';
 import { LogListContextData, Props } from '../LogListContext';
 import { LogListModel } from '../processing';
 
+jest.mock('@grafana/assistant', () => {
+  return {
+    ...jest.requireActual('@grafana/assistant'),
+    useAssistant: jest.fn().mockReturnValue([true, jest.fn()]),
+  };
+});
+
 export const LogListContext = createContext<LogListContextData>({
   app: CoreApp.Unknown,
   closeDetails: () => {},
@@ -43,6 +50,8 @@ export const LogListContext = createContext<LogListContextData>({
   setDetailsMode: function (mode: LogLineDetailsMode): void {
     throw new Error('Function not implemented.');
   },
+  isAssistantAvailable: false,
+  openAssistantByLog: () => {},
 });
 
 export const useLogListContextData = (key: keyof LogListContextData) => {
@@ -97,6 +106,8 @@ export const defaultValue: LogListContextData = {
   showTime: false,
   sortOrder: LogsSortOrder.Ascending,
   wrapLogMessage: false,
+  isAssistantAvailable: false,
+  openAssistantByLog: () => {},
 };
 
 export const defaultProps: Props = {
diff --git a/public/app/plugins/panel/logs-new/LogsPanel.test.tsx b/public/app/plugins/panel/logs-new/LogsPanel.test.tsx
index 77570bf19ab..09997a66047 100644
--- a/public/app/plugins/panel/logs-new/LogsPanel.test.tsx
+++ b/public/app/plugins/panel/logs-new/LogsPanel.test.tsx
@@ -18,6 +18,11 @@ import { LogsPanel } from './LogsPanel';
 
 type LogsPanelProps = ComponentProps<typeof LogsPanel>;
 
+jest.mock('@grafana/assistant', () => ({
+  ...jest.requireActual('@grafana/assistant'),
+  useAssistant: jest.fn(() => [true, jest.fn()]),
+}));
+
 jest.mock('@grafana/runtime', () => ({
   ...jest.requireActual('@grafana/runtime'),
   getAppEvents: jest.fn(),
diff --git a/public/app/plugins/panel/logs/LogsPanel.test.tsx b/public/app/plugins/panel/logs/LogsPanel.test.tsx
index 6a299326f85..64ef4a60a44 100644
--- a/public/app/plugins/panel/logs/LogsPanel.test.tsx
+++ b/public/app/plugins/panel/logs/LogsPanel.test.tsx
@@ -57,6 +57,13 @@ jest.mock('@grafana/data', () => ({
   hasLogsContextSupport: (ds: MockDataSourceApi) => hasLogsContextSupport(ds),
 }));
 
+jest.mock('@grafana/assistant', () => {
+  return {
+    ...jest.requireActual('@grafana/assistant'),
+    useAssistant: jest.fn().mockReturnValue([true, jest.fn()]),
+  };
+});
+
 const defaultProps = {
   data: {
     error: undefined,
diff --git a/public/locales/en-US/grafana.json b/public/locales/en-US/grafana.json
index 7a1a46a7138..180039f2b38 100644
--- a/public/locales/en-US/grafana.json
+++ b/public/locales/en-US/grafana.json
@@ -9331,6 +9331,7 @@
       "move-displayed-field-down": "Move down",
       "move-displayed-field-up": "Move up",
       "no-details": "No fields to display.",
+      "open-assistant": "Explain this log line in Assistant",
       "pin-line": "Pin log",
       "remove-displayed-field": "Remove field",
       "remove-log": "Remove log",
@@ -9349,6 +9350,9 @@
       "copy-log": "Copy log line",
       "hide-details": "Show log details",
       "icon-label": "Log menu",
+      "log-line": "Log line",
+      "log-line-explainer": "Explain this log line in a concise way",
+      "open-assistant": "Explain this log line in Assistant",
       "pin-to-outline": "Pin log",
       "show-context": "Show context",
       "show-details": "Hide log details",
diff --git a/yarn.lock b/yarn.lock
index 866a76ae882..7bcd86a7b5a 100644
--- a/yarn.lock
+++ b/yarn.lock
@@ -3064,6 +3064,20 @@ __metadata:
   languageName: unknown
   linkType: soft
 
+"@grafana/assistant@npm:0.0.7":
+  version: 0.0.7
+  resolution: "@grafana/assistant@npm:0.0.7"
+  peerDependencies:
+    "@grafana/data": ">=12.0.0"
+    "@grafana/runtime": ">=12.0.0"
+    "@grafana/scenes": ">=5.41.0"
+    "@grafana/ui": ">=12.0.0"
+    react: ">=18.0.0"
+    rxjs: ">=7.0.0"
+  checksum: 10/c83523a032cb748867f683e87ad5b00a04bb4918ae5c7aafe5587b418b73b769a92de948335f0d9055d06036004e7a9794722f627cab3111b076eb27423d4344
+  languageName: node
+  linkType: hard
+
 "@grafana/async-query-data@npm:0.4.1":
   version: 0.4.1
   resolution: "@grafana/async-query-data@npm:0.4.1"
@@ -17832,6 +17846,7 @@ __metadata:
     "@formatjs/intl-durationformat": "npm:^0.7.0"
     "@glideapps/glide-data-grid": "npm:^6.0.0"
     "@grafana/alerting": "workspace:*"
+    "@grafana/assistant": "npm:0.0.7"
     "@grafana/aws-sdk": "npm:0.7.1"
     "@grafana/azure-sdk": "npm:0.0.7"
     "@grafana/data": "workspace:*"