diff --git a/e2e-playwright/dashboard-new-layouts/dashboard-group-panels.spec.ts b/e2e-playwright/dashboard-new-layouts/dashboard-group-panels.spec.ts
index c35eb03bf84..ad954267c85 100644
--- a/e2e-playwright/dashboard-new-layouts/dashboard-group-panels.spec.ts
+++ b/e2e-playwright/dashboard-new-layouts/dashboard-group-panels.spec.ts
@@ -419,6 +419,9 @@ test.describe(
       // Select tabs layout
       await page.getByLabel('layout-selection-option-Tabs').click();
 
+      // confirm layout change
+      await dashboardPage.getByGrafanaSelector(selectors.pages.ConfirmModal.delete).click();
+
       await expect(dashboardPage.getByGrafanaSelector(selectors.components.Tab.title('New row'))).toBeVisible();
       await expect(dashboardPage.getByGrafanaSelector(selectors.components.Tab.title('New row 1'))).toBeVisible();
       await expect(
@@ -757,6 +760,9 @@ test.describe(
       // Select rows layout
       await page.getByLabel('layout-selection-option-Rows').click();
 
+      // confirm layout change
+      await dashboardPage.getByGrafanaSelector(selectors.pages.ConfirmModal.delete).click();
+
       await dashboardPage
         .getByGrafanaSelector(selectors.components.DashboardRow.wrapper('New tab 1'))
         .scrollIntoViewIfNeeded();
diff --git a/e2e-playwright/dashboard-new-layouts/dashboards-panel-layouts.spec.ts b/e2e-playwright/dashboard-new-layouts/dashboards-panel-layouts.spec.ts
index ffacaa13912..803f9d18d46 100644
--- a/e2e-playwright/dashboard-new-layouts/dashboards-panel-layouts.spec.ts
+++ b/e2e-playwright/dashboard-new-layouts/dashboards-panel-layouts.spec.ts
@@ -4,6 +4,8 @@ import { test, expect, E2ESelectorGroups, DashboardPage } from '@grafana/plugin-
 
 import testV2Dashboard from '../dashboards/TestV2Dashboard.json';
 
+import { switchToAutoGrid } from './utils';
+
 test.use({
   featureToggles: {
     kubernetesDashboards: true,
@@ -33,7 +35,8 @@ test.describe(
       ).toHaveCount(3);
 
       await dashboardPage.getByGrafanaSelector(selectors.pages.Dashboard.Sidebar.optionsButton).click();
-      await page.getByLabel('layout-selection-option-Auto grid').click();
+
+      await switchToAutoGrid(page, dashboardPage);
 
       await expect(
         dashboardPage.getByGrafanaSelector(selectors.components.Panels.Panel.title('New panel'))
@@ -64,7 +67,8 @@ test.describe(
       ).toHaveCount(3);
 
       await dashboardPage.getByGrafanaSelector(selectors.pages.Dashboard.Sidebar.optionsButton).click();
-      await page.getByLabel('layout-selection-option-Auto grid').click();
+
+      await switchToAutoGrid(page, dashboardPage);
 
       // Get initial positions - standard width should have panels on different rows
       const firstPanelTop = await getPanelTop(dashboardPage, selectors);
@@ -124,7 +128,8 @@ test.describe(
       ).toHaveCount(3);
 
       await dashboardPage.getByGrafanaSelector(selectors.pages.Dashboard.Sidebar.optionsButton).click();
-      await page.getByLabel('layout-selection-option-Auto grid').click();
+
+      await switchToAutoGrid(page, dashboardPage);
 
       await dashboardPage
         .getByGrafanaSelector(selectors.components.PanelEditor.ElementEditPane.AutoGridLayout.minColumnWidth)
@@ -181,7 +186,8 @@ test.describe(
       ).toHaveCount(3);
 
       await dashboardPage.getByGrafanaSelector(selectors.pages.Dashboard.Sidebar.optionsButton).click();
-      await page.getByLabel('layout-selection-option-Auto grid').click();
+
+      await switchToAutoGrid(page, dashboardPage);
 
       await dashboardPage
         .getByGrafanaSelector(selectors.components.PanelEditor.ElementEditPane.AutoGridLayout.maxColumns)
@@ -216,7 +222,8 @@ test.describe(
       ).toHaveCount(3);
 
       await dashboardPage.getByGrafanaSelector(selectors.pages.Dashboard.Sidebar.optionsButton).click();
-      await page.getByLabel('layout-selection-option-Auto grid').click();
+
+      await switchToAutoGrid(page, dashboardPage);
 
       const regularRowHeight = await getPanelHeight(dashboardPage, selectors);
 
@@ -271,7 +278,8 @@ test.describe(
       ).toHaveCount(3);
 
       await dashboardPage.getByGrafanaSelector(selectors.pages.Dashboard.Sidebar.optionsButton).click();
-      await page.getByLabel('layout-selection-option-Auto grid').click();
+
+      await switchToAutoGrid(page, dashboardPage);
 
       const regularRowHeight = await getPanelHeight(dashboardPage, selectors);
 
@@ -328,7 +336,8 @@ test.describe(
       ).toHaveCount(3);
 
       await dashboardPage.getByGrafanaSelector(selectors.pages.Dashboard.Sidebar.optionsButton).click();
-      await page.getByLabel('layout-selection-option-Auto grid').click();
+
+      await switchToAutoGrid(page, dashboardPage);
 
       // Set narrow column width first to ensure panels fit horizontally
       await dashboardPage
diff --git a/e2e-playwright/dashboard-new-layouts/dashboards-repeats-auto-grid.spec.ts b/e2e-playwright/dashboard-new-layouts/dashboards-repeats-auto-grid.spec.ts
index dbba5c583c1..3e25adc6c41 100644
--- a/e2e-playwright/dashboard-new-layouts/dashboards-repeats-auto-grid.spec.ts
+++ b/e2e-playwright/dashboard-new-layouts/dashboards-repeats-auto-grid.spec.ts
@@ -1,6 +1,6 @@
 import { Page } from 'playwright-core';
 
-import { test, expect } from '@grafana/plugin-e2e';
+import { test, expect, DashboardPage } from '@grafana/plugin-e2e';
 
 import testV2DashWithRepeats from '../dashboards/V2DashWithRepeats.json';
 
@@ -12,6 +12,7 @@ import {
   getPanelPosition,
   importTestDashboard,
   goToEmbeddedPanel,
+  switchToAutoGrid,
 } from './utils';
 
 const repeatTitleBase = 'repeat - ';
@@ -42,7 +43,7 @@ test.describe(
       await dashboardPage.getByGrafanaSelector(selectors.components.NavToolbar.editDashboard.editButton).click();
       await dashboardPage.getByGrafanaSelector(selectors.pages.Dashboard.Sidebar.optionsButton).click();
 
-      await switchToAutoGrid(page);
+      await switchToAutoGrid(page, dashboardPage);
 
       await dashboardPage.getByGrafanaSelector(selectors.components.Panels.Panel.title('New panel')).first().click();
 
@@ -78,7 +79,8 @@ test.describe(
       await dashboardPage.getByGrafanaSelector(selectors.components.NavToolbar.editDashboard.editButton).click();
       await dashboardPage.getByGrafanaSelector(selectors.pages.Dashboard.Sidebar.optionsButton).click();
 
-      await switchToAutoGrid(page);
+      await switchToAutoGrid(page, dashboardPage);
+
       await saveDashboard(dashboardPage, page, selectors);
       await page.reload();
 
@@ -117,7 +119,7 @@ test.describe(
       await dashboardPage.getByGrafanaSelector(selectors.components.NavToolbar.editDashboard.editButton).click();
       await dashboardPage.getByGrafanaSelector(selectors.pages.Dashboard.Sidebar.optionsButton).click();
 
-      await switchToAutoGrid(page);
+      await switchToAutoGrid(page, dashboardPage);
 
       // select first/original repeat panel to activate edit pane
       await dashboardPage
@@ -148,7 +150,7 @@ test.describe(
       await dashboardPage.getByGrafanaSelector(selectors.components.NavToolbar.editDashboard.editButton).click();
       await dashboardPage.getByGrafanaSelector(selectors.pages.Dashboard.Sidebar.optionsButton).click();
 
-      await switchToAutoGrid(page);
+      await switchToAutoGrid(page, dashboardPage);
       await saveDashboard(dashboardPage, page, selectors);
       await page.reload();
 
@@ -214,7 +216,7 @@ test.describe(
       await dashboardPage.getByGrafanaSelector(selectors.components.NavToolbar.editDashboard.editButton).click();
       await dashboardPage.getByGrafanaSelector(selectors.pages.Dashboard.Sidebar.optionsButton).click();
 
-      await switchToAutoGrid(page);
+      await switchToAutoGrid(page, dashboardPage);
       await saveDashboard(dashboardPage, page, selectors);
 
       // loading directly into panel editor
@@ -271,7 +273,7 @@ test.describe(
       await dashboardPage.getByGrafanaSelector(selectors.components.NavToolbar.editDashboard.editButton).click();
       await dashboardPage.getByGrafanaSelector(selectors.pages.Dashboard.Sidebar.optionsButton).click();
 
-      await switchToAutoGrid(page);
+      await switchToAutoGrid(page, dashboardPage);
 
       // this moving repeated panel between two normal panels
       await movePanel(dashboardPage, selectors, `${repeatTitleBase}${repeatOptions.at(0)}`, 'New panel');
@@ -319,7 +321,7 @@ test.describe(
       await dashboardPage.getByGrafanaSelector(selectors.components.NavToolbar.editDashboard.editButton).click();
       await dashboardPage.getByGrafanaSelector(selectors.pages.Dashboard.Sidebar.optionsButton).click();
 
-      await switchToAutoGrid(page);
+      await switchToAutoGrid(page, dashboardPage);
       await saveDashboard(dashboardPage, page, selectors);
       await page.reload();
 
@@ -382,7 +384,7 @@ test.describe(
       await dashboardPage.getByGrafanaSelector(selectors.components.NavToolbar.editDashboard.editButton).click();
       await dashboardPage.getByGrafanaSelector(selectors.pages.Dashboard.Sidebar.optionsButton).click();
 
-      await switchToAutoGrid(page);
+      await switchToAutoGrid(page, dashboardPage);
       await saveDashboard(dashboardPage, page, selectors);
       await page.reload();
 
@@ -410,7 +412,7 @@ test.describe(
       await dashboardPage.getByGrafanaSelector(selectors.components.NavToolbar.editDashboard.editButton).click();
       await dashboardPage.getByGrafanaSelector(selectors.pages.Dashboard.Sidebar.optionsButton).click();
 
-      await switchToAutoGrid(page);
+      await switchToAutoGrid(page, dashboardPage);
       await saveDashboard(dashboardPage, page, selectors);
       await page.reload();
 
@@ -462,7 +464,3 @@ test.describe(
     });
   }
 );
-
-async function switchToAutoGrid(page: Page) {
-  await page.getByLabel('layout-selection-option-Auto grid').click();
-}
diff --git a/e2e-playwright/dashboard-new-layouts/utils.ts b/e2e-playwright/dashboard-new-layouts/utils.ts
index 83508063ef5..69851994812 100644
--- a/e2e-playwright/dashboard-new-layouts/utils.ts
+++ b/e2e-playwright/dashboard-new-layouts/utils.ts
@@ -1,5 +1,6 @@
 import { Page } from '@playwright/test';
 
+import { selectors } from '@grafana/e2e-selectors';
 import { DashboardPage, E2ESelectorGroups, expect } from '@grafana/plugin-e2e';
 
 import testV2Dashboard from '../dashboards/TestV2Dashboard.json';
@@ -239,3 +240,12 @@ export async function getTabPosition(dashboardPage: DashboardPage, selectors: E2
   const boundingBox = await tab.boundingBox();
   return boundingBox;
 }
+
+export async function switchToAutoGrid(page: Page, dashboardPage: DashboardPage) {
+  await page.getByLabel('layout-selection-option-Auto grid').click();
+  // confirm layout change if applicable
+  const confirmModal = dashboardPage.getByGrafanaSelector(selectors.pages.ConfirmModal.delete);
+  if (confirmModal) {
+    await confirmModal.click();
+  }
+}
diff --git a/public/app/features/dashboard-scene/scene/layouts-shared/DashboardLayoutSelector.test.tsx b/public/app/features/dashboard-scene/scene/layouts-shared/DashboardLayoutSelector.test.tsx
new file mode 100644
index 00000000000..d363a95ddf0
--- /dev/null
+++ b/public/app/features/dashboard-scene/scene/layouts-shared/DashboardLayoutSelector.test.tsx
@@ -0,0 +1,72 @@
+import { render, screen } from '@testing-library/react';
+import userEvent from '@testing-library/user-event';
+
+import { getPanelPlugin } from '@grafana/data/test';
+import { setPluginImportUtils } from '@grafana/runtime';
+import { SceneGridLayout, VizPanel, SceneVariableSet } from '@grafana/scenes';
+
+import { activateFullSceneTree } from '../../utils/test-utils';
+import { DashboardScene } from '../DashboardScene';
+import { DashboardGridItem } from '../layout-default/DashboardGridItem';
+import { DefaultGridLayoutManager } from '../layout-default/DefaultGridLayoutManager';
+import { RowItem } from '../layout-rows/RowItem';
+import { RowsLayoutManager } from '../layout-rows/RowsLayoutManager';
+import { LayoutParent } from '../types/LayoutParent';
+
+import { DashboardLayoutSelector } from './DashboardLayoutSelector';
+
+const switchLayoutMock = jest.fn();
+
+setPluginImportUtils({
+  importPanelPlugin: (_) => Promise.resolve(getPanelPlugin({})),
+  getPanelPluginFromCache: (_) => undefined,
+});
+
+describe('DashboardLayoutSelector', () => {
+  it('should show confirmation modal when switching layouts', async () => {
+    const user = userEvent.setup();
+    const scene = buildTestScene();
+    const layoutManager = scene.state.body;
+    (layoutManager.parent as LayoutParent).switchLayout = switchLayoutMock;
+
+    render(<DashboardLayoutSelector layoutManager={layoutManager} />);
+
+    await user.click(screen.getByLabelText('layout-selection-option-Tabs'));
+
+    const confirmButton = screen.getByRole('button', { name: 'Change layout' });
+
+    expect(confirmButton).toBeInTheDocument();
+
+    await user.click(confirmButton);
+    expect(switchLayoutMock).toHaveBeenCalled();
+  });
+});
+
+const buildTestScene = () => {
+  const scene = new DashboardScene({
+    title: 'testScene',
+    editable: true,
+    $variables: new SceneVariableSet({
+      variables: [],
+    }),
+    body: new RowsLayoutManager({
+      rows: [
+        new RowItem({
+          title: 'Row 1',
+          layout: new DefaultGridLayoutManager({
+            grid: new SceneGridLayout({
+              children: [
+                new DashboardGridItem({
+                  body: new VizPanel({ key: 'panel-1', pluginId: 'text' }),
+                }),
+              ],
+            }),
+          }),
+        }),
+      ],
+    }),
+  });
+
+  activateFullSceneTree(scene);
+  return scene;
+};
diff --git a/public/app/features/dashboard-scene/scene/layouts-shared/DashboardLayoutSelector.tsx b/public/app/features/dashboard-scene/scene/layouts-shared/DashboardLayoutSelector.tsx
index e959352986a..b32555b32f8 100644
--- a/public/app/features/dashboard-scene/scene/layouts-shared/DashboardLayoutSelector.tsx
+++ b/public/app/features/dashboard-scene/scene/layouts-shared/DashboardLayoutSelector.tsx
@@ -1,8 +1,8 @@
-import { useCallback, useMemo } from 'react';
+import { useCallback, useMemo, useState } from 'react';
 
 import { t } from '@grafana/i18n';
 import { config } from '@grafana/runtime';
-import { RadioButtonGroup, Box } from '@grafana/ui';
+import { RadioButtonGroup, Box, ConfirmModal } from '@grafana/ui';
 import { OptionsPaneCategoryDescriptor } from 'app/features/dashboard/components/PanelEditor/OptionsPaneCategoryDescriptor';
 import { OptionsPaneItemDescriptor } from 'app/features/dashboard/components/PanelEditor/OptionsPaneItemDescriptor';
 
@@ -20,6 +20,7 @@ export interface Props {
 export function DashboardLayoutSelector({ layoutManager }: Props) {
   const isGridLayout = layoutManager.descriptor.isGridLayout;
   const options = layoutRegistry.list().filter((layout) => layout.isGridLayout === isGridLayout);
+  const [newLayout, setNewLayout] = useState<LayoutRegistryItem | undefined>();
 
   const disableTabs = useMemo(() => {
     if (config.featureToggles.unlimitedLayoutsNesting) {
@@ -36,16 +37,23 @@ export function DashboardLayoutSelector({ layoutManager }: Props) {
     return false;
   }, [layoutManager]);
 
-  const onChangeLayout = useCallback(
-    (newLayout: LayoutRegistryItem) => {
-      const layoutParent = layoutManager.parent;
+  const onChangeLayout = useCallback((newLayout: LayoutRegistryItem) => setNewLayout(newLayout), []);
 
-      if (layoutParent && isLayoutParent(layoutParent)) {
-        layoutParent.switchLayout(newLayout.createFromLayout(layoutManager));
-      }
-    },
-    [layoutManager]
-  );
+  const onConfirmNewLayout = useCallback(() => {
+    if (!newLayout) {
+      return;
+    }
+
+    const layoutParent = layoutManager.parent;
+
+    if (layoutParent && isLayoutParent(layoutParent)) {
+      layoutParent.switchLayout(newLayout.createFromLayout(layoutManager));
+    }
+
+    setNewLayout(undefined);
+  }, [newLayout, layoutManager]);
+
+  const onDismissNewLayout = useCallback(() => setNewLayout(undefined), []);
 
   const disabledOptions: LayoutRegistryItem[] = [];
 
@@ -66,15 +74,27 @@ export function DashboardLayoutSelector({ layoutManager }: Props) {
   });
 
   return (
-    <Box paddingBottom={2} display="flex" grow={1} alignItems="stretch" gap={2} direction={'column'}>
-      <RadioButtonGroup
-        fullWidth
-        value={layoutManager.descriptor}
-        options={radioOptions}
-        onChange={onChangeLayout}
-        disabledOptions={disabledOptions}
+    <>
+      <Box paddingBottom={2} display="flex" grow={1} alignItems="stretch" gap={2} direction={'column'}>
+        <RadioButtonGroup
+          fullWidth
+          value={layoutManager.descriptor}
+          options={radioOptions}
+          onChange={onChangeLayout}
+          disabledOptions={disabledOptions}
+        />
+      </Box>
+      <ConfirmModal
+        isOpen={!!newLayout}
+        title={t('dashboard.layout.panel.modal.title', 'Change layout')}
+        body={t('dashboard.layout.panel.modal.body', 'Changing the layout will reset all panel positions and sizes.')}
+        confirmText={t('dashboard.layout.panel.modal.confirm', 'Change layout')}
+        dismissText={t('dashboard.layout.panel.modal.dismiss', 'Cancel')}
+        confirmButtonVariant="primary"
+        onConfirm={onConfirmNewLayout}
+        onDismiss={onDismissNewLayout}
       />
-    </Box>
+    </>
   );
 }
 export function useLayoutCategory(layoutManager: DashboardLayoutManager) {
diff --git a/public/locales/en-US/grafana.json b/public/locales/en-US/grafana.json
index 761ed8f51ec..90b047262a3 100644
--- a/public/locales/en-US/grafana.json
+++ b/public/locales/en-US/grafana.json
@@ -5093,6 +5093,14 @@
         "layout": "Layout"
       },
       "continue": "Continue",
+      "panel": {
+        "modal": {
+          "body": "Changing the layout will reset all panel positions and sizes.",
+          "confirm": "Change layout",
+          "dismiss": "Cancel",
+          "title": "Change layout"
+        }
+      },
       "ungroup-nested-text": "This will ungroup all nested groups.",
       "ungroup-nested-title": "Ungroup nested groups?"
     },